Evaluation of retinal and choroidal microcirculation in Behçet’s disease

Şimşek, Mert; Aksoy, Mustafa; Ulucaköy, Rezan Koçak

doi:10.1038/s41433-022-01932-8

Cited by 10 publications

(6 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These results are essential in respect of indicating that retinal microvascular alterations appear before the emergence of ocular manifestations. Previous studies found higher choroid thickness in non-ocular BD, indicating the potential of subclinical choroidal inflammation (8,19). Moreover, significantly increased serum levels of resistin, tumor necrosis factor-α and lnterleukin-6 have been demonstrated in nonocular BD, indicating the deviation of inflammatory and anti-inflammatory balance (25,26).…”

Section: Discussionmentioning

confidence: 91%

“…However, the results vary widely among different studies. Slightly decreased vessel densities of fovea and parafovea in non-ocular BD were observed in comparison to healthy individuals, while others demonstrated significantly reduced macular perfusion in corresponding regions (9,10,18,19). To elucidate the confusing data, this meta-analysis was performed to identify the retinal and choroidal characteristics of non-ocular BD.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, 9 investigations focusing on BD patients with clinical ocular manifestations, 1 record focusing on optic disc of BD, 3 conference abstracts, 1 article without sufficient data and 1 study without healthy control group were excluded. Therefore, as shown in Figure 1, 10 original cross-sectional investigations were eventually included for quantitatively synthesis in the present meta-analysis (8)(9)(10)(13)(14)(15)(16)(17)(18)(19).…”

Section: Study Inclusionmentioning

confidence: 99%

See 2 more Smart Citations

Retinal and choroidal microvascular alterations in Behcet’s disease without ocular manifestations: A systematic review and meta-analysis

et al. 2022

View full text Add to dashboard Cite

PurposeWe performed a systematic review and meta-analysis to examine the microvascular alterations in non-ocular Behcet’s disease (BD) using optical coherence tomography angiography (OCTA).MethodsA comprehensive search was performed in Pubmed, Embase and Cochrane databases for eligible studies from inception to February 2022. Detailed clinical demographics were extracted from each study by two independent reviewers. The weighted mean difference (WMD) and 95% confidence intervals (CI) were used to compare the OCTA parameters between non-ocular BD and healthy controls. Stata 12.0 was adopted to conduct statistical analyses.ResultsTen cross-sectional studies involving 386 eyes in non-ocular BD and 418 eyes in healthy volunteers were ultimately included in the present analysis. When considering superficial capillary plexus (SCP) and deep capillary plexus (DCP), no significant differences of vessel densities in the whole enface image, fovea and perifovea were evaluated between two groups. Significantly reduced parafoveal vessel density of SCP was observed in non-ocular BD in comparison with healthy group (WMD = −1.33, 95%CI: −1.78, −0.89; I2 = 0.6%), while slightly decreased parafoveal vessel density was assessed in DCP (WMD = −1.47, 95%CI: −3.30, 0.35; I2 = 89.3%). Significantly increasing foveal avascular zone (FAZ) area was observed in non-ocular BD when compared to healthy controls (WMD = 0.11, 95%CI: 0.03, 0.19; I2 = 95.3%). There was no significant difference in flow area of choriocapillaris between non-ocular BD and control group (WMD = 0.06, 95%CI: −0.19, 0.32; I2 = 0%).ConclusionBased on current analysis, our results demonstrated significantly lower parafoveal vessel density of SCP and lager FAZ area in full vasculature in non-ocular BD. The retinal microvascular alterations appear before the emergence of ocular manifestations.Systematic Trial Registration[https://www.crd.york.ac.uk/PROSPERO/], identifier [CRD42021244856].

show abstract

Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Study Inclusionmentioning

confidence: 99%

See 1 more Smart Citation

Retinal and choroidal microvascular alterations in Behcet’s disease without ocular manifestations: A systematic review and meta-analysis

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Likewise, Agrawal et al 18 have demonstrated a decrease in CVI at 3 months follow-up in patients with panuveitis. Moreover, Şimşek et al 29 showed that CVI was signi cantly lower in non-uveitic patients with BD compared to healthy controls. Therefore, our ndings were consistent with these current articles and reported signi cantly decreased CVI values in eyes with NIU and NU patients compared to controls.…”

Section: Discussionmentioning

confidence: 99%

Effect of adalimumab on choroidal thickness and choroidal vascularity index in eyes with non-infectious uveitis using enhanced-depth imaging optical coherence tomography

Evereklioğlu

Arslantas²,

Şener

et al. 2023

Preprint

View full text Add to dashboard Cite

Objective To evaluate the effect of adalimumab (ADA) on choroidal thickness (ChT) and choroidal vascularity index (CVI) in eyes with non-infectious uveitis (NIU). Methods Thirty-seven eyes with NIU, 38 eyes of non-uveitic (NU) patients, and 40 control eyes were included. ADA was used for anti-TNF-naive adult (80mg) or pediatric (40mg) patients with refractory NIU, then 40mg every 2-week (20mg in children < 30kg) with controls at weeks 1, 4, 12, and 24. Images were used to measure central, nasal, and temporal ChT, and the luminal area (LA), stromal area (SA), and total choroidal area (TCA) were analysed using enhanced-depth imaging optical coherence tomography (EDI-OCT) by ImageJ software. The CVI was then calculated as the ratio of LA to TCA. Results Mean ages were similar between the groups. Mean (SE) subfoveal ChT measurements for each location were also similar (for each, p > 0.05). However, calculated CVI values in eyes with NIU (0.63 ± 0.007) were significantly (p < 0.001) lower than NU eyes (0.66 ± 0.006) and controls (0.70 ± 0.007) (p < 0.001). Moreover, CVI was significantly lower in NU eyes compared to controls (p < 0.001). There were no significant CVI changes between the consecutive visits after ADA therapy in eyes with NIU (for each, p > 0.05). Conclusions Decreased CVI in NIU and NU eyes indicates that systemic inflammation affects the choroidal vasculature and perfusion both in the presence and absence of ocular involvement. Although CVI may be used as a possible novel tool in monitoring ocular involvement and progression of NIU, CVI does not seem to be a biomarker for treatment monitoring in NIU.

show abstract

“…Another study among non-ocular patients showed no deficit in retinal microcirculation by OCTA, and suggested that choroidal vascularity index by OCT may be a more reliable marker of choroidal perfusion. (31). The mean density of the subbasal nerve plexus was significantly lower, and nerve tortuosity was significantly higher in patients with ocular involvement (32).…”

Section: Clinical Manifestations Eye Involvementmentioning

confidence: 91%

Behçet's yndrome: one year in review 2023

Hatemi,

Seyahi,

Fresko

et al. 2023

Clinical and Experimental Rheumatology

View full text Add to dashboard Cite

Evaluation of retinal and choroidal microcirculation in Behçet’s disease

Cited by 10 publications

References 26 publications

Retinal and choroidal microvascular alterations in Behcet’s disease without ocular manifestations: A systematic review and meta-analysis

Retinal and choroidal microvascular alterations in Behcet’s disease without ocular manifestations: A systematic review and meta-analysis

Effect of adalimumab on choroidal thickness and choroidal vascularity index in eyes with non-infectious uveitis using enhanced-depth imaging optical coherence tomography

Behçet's yndrome: one year in review 2023

Contact Info

Product

Resources

About