Evaluation of required saline volume in dynamic contrast-enhanced computed tomography using saline flush technique

Yamaguchi, Isao; Kidoya, Eiji; Suzuki, Masayuki; Kimura, Hirohiko

doi:10.1016/j.compmedimag.2008.09.005

Cited by 13 publications

(6 citation statements)

References 22 publications

(23 reference statements)

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“…The aortic enhancement rate, the rise time and the time to peak enhancement of the hepatic portal system from the time to the trigger threshold (trigger time) were calculated in the simulation. The aortic enhancement rate was the slope of the linear equation of increased CT value which ranged from 5 HU (contrast medium aortic arrival time) to the average trigger threshold in the clinical study (in HU/s) [44]. The rise time was the elapsed time to peak aortic enhancement from the contrast medium's aortic arrival time (Fig.…”

Section: Analysis Of Tecs In the Simulation Studymentioning

confidence: 99%

“…The administered contrast material dose reduced the dead space volume (the contrast medium remaining in both the injector tube and the venous segment including the infused vein and subclavian vein). The volume of dead space was set at 18 mL [44]. Based on this assumption, a closed circuit that circulates from the pulmonary compartment is distributed into the aorta, and it reaches the pulmonary compartment again through the systemic circulation that was simulated.…”

Section: Simulation Of Tecs In Pharmacokinetic Analysismentioning

confidence: 99%

“…Transformation into attenuation values was based on the correlation between the iodine concentration and the attenuation value observed with the CT scanner (i.e., 1.0 mg I/mL = 25.22 HU) [44].…”

Section: Analysis Of Tecs In the Simulation Studymentioning

confidence: 99%

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Optimizing scan timing of hepatic arterial phase by physiologic pharmacokinetic analysis in bolus-tracking technique by multi-detector row computed tomography

Yamaguchi

Kidoya

Suzuki

et al. 2010

Radiol Phys Technol

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Our aim in this study was to determine an optimal delay time of hepatic arterial phase (HAP) imaging of hypervascular hepatocellular carcinomas (HCCs) in dynamic contrast-enhanced MDCT (DCE-CT) by use of the bolus-tracking method. The time-enhancement curves (TECs) of the aorta and the contrast of the hepatic arterial and portal system (APC) in the pharmacokinetic analysis were calculated. The clinical study included 41 patients with known or suspected HCC who underwent DCE-CT. The TECs of the aorta and the tumor-liver contrast (TLC) in the clinical study were calculated. On pharmacokinetic analysis, the peak aortic enhancement and the peak APC simulated under conditions of an injection duration of 30 s and an iodine load of 500 mg I/kg body weight were observed 18.5 and 22.5 s, respectively, after the trigger threshold (increased CT value 100 Hounsfield units), respectively. In the clinical study, the peak aortic enhancement and the peak TLC were observed 17.2 and 24.8 s after the trigger threshold, respectively. The optimal delay times until peak aortic enhancement and peak HAP were 15-17 and 19-21 s after the trigger threshold, respectively, under the following conditions: injection dose, 500 mg I/kg body weight; injection duration, 30 s; acquisition time, 5 s; and the trigger threshold. In addition, the peak TLC was achieved 4-7 s after the time to peak aortic enhancement.

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Section: Analysis Of Tecs In the Simulation Studymentioning

confidence: 99%

Section: Simulation Of Tecs In Pharmacokinetic Analysismentioning

confidence: 99%

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Optimizing scan timing of hepatic arterial phase by physiologic pharmacokinetic analysis in bolus-tracking technique by multi-detector row computed tomography

Yamaguchi

Kidoya

Suzuki

et al. 2010

Radiol Phys Technol

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“…The ideal volume of saline flush for decreasing the onset time is unclear. Yamaguchi et al 12 investigated the required volume of saline flush that allows efficient use of contrast medium for dynamic computed tomography. By comparing the time courses of measured and simulated computed tomography values in the aorta, they estimated that the volume of the vein segment including the antecubital and subclavian veins was 18 mL.…”

Section: Discussionmentioning

confidence: 99%

Saline Flush After Rocuronium Bolus Reduces Onset Time and Prolongs Duration of Effect

Ishigaki

Masui

Kazama

2016

Anesthesia &Amp; Analgesia

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“…2c). Saline decreases the amount of required CM volume without affecting the level of vascular opacification (37). Moreover, saline chaser was found to increase the extent of peak arterial opacification (38).…”

Section: Contrast Media Parametersmentioning

confidence: 92%

Contrast medium administration and image acquisition parameters in renal CT angiography: what radiologists need to know

Saade

Deeb²,

Mohamad³

et al. 2016

Diagn Interv Radiol

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P ersonalized medicine is a popular topic in radiology today. Scientists are flooding academic journals, conference proceedings, and book chapters with arguments about radiation reduction strategies with a personalized approach. However, contrast media (CM) dose reduction has been overlooked, which is of great concern. As such, 3% of all patients admitted for renal dialysis are a direct result of excessive CM volume delivered during radiologic imaging in the course of their hospital stay (1).Studies suggest that CM volumes employed during renal computed tomography (CT) angiography (CTA) range from 30-120 mL (2-4). This wide array of CM dose has different effects on scanner parameters. For example, employing 30 mL CM volume with a tube current selection of 80 kVp renders acceptable image quality. However, image quality can either be quantitative or qualitative in nature, which increase the subjectivity of good versus acceptable image quality with desired CM doses. Therefore, judging optimal image quality is determined by the amount of noise and vascular opacification of the renal arteries.Vascular opacification that is too low may compromise the visualization of small renal vasculature and underestimate plaque formation and stenosis (5). Previous studies on contrast-injection protocols for renal CTA suggested that the adequate attenuation value for the arteries is greater than 211 Hounsfield units (HU) (6). However, attenuation values of the renal arteries have reached as high as 435±48 HU, while those of the renal veins have reached 277±29 HU (7).The sensitivity and specificity for diagnosing greater than 50% renal artery stenosis during renal CTA range from 67%-100% and 77%-98%, respectively (8). Renal magnetic resonance angiography (MRA) has sensitivity and specificity of 88%-100% and 70%-100% with low interobserver variability, especially for severe stenosis greater than 70% (9).Renal CTA provides accurate, noninvasive, and time-efficient diagnostic evaluation for medical management of renal arterial disease as well as creating a roadmap prior to surgical intervention. Such clinical questions arise when a hypertensive individual has renal CTA to exclude renal artery stenosis, fibromuscular dysplasia, or dissection. Pathology-specific renal CTA examinations include determining if vasculitis involves the renal arteries or the extent of renal aneurysmal changes. Preoperative renal CTA planning can be useful for nephron-sparing surgery prior to resection of renal masses or as post-procedural follow-up of renal stenting or surgical revascularization. Finally, renal CTA is also employed in the evaluation of the kidney donor and recipient prior to transplantation. ABSTRACTOver the last decade, exponential advances in computed tomography (CT) technology have resulted in improved spatial and temporal resolution. Faster image acquisition enabled renal CT angiography to become a viable and effective noninvasive alternative in diagnosing renal vascular pathologies. However, with these advances, new challenges in contras...

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Evaluation of required saline volume in dynamic contrast-enhanced computed tomography using saline flush technique

Cited by 13 publications

References 22 publications

Optimizing scan timing of hepatic arterial phase by physiologic pharmacokinetic analysis in bolus-tracking technique by multi-detector row computed tomography

Optimizing scan timing of hepatic arterial phase by physiologic pharmacokinetic analysis in bolus-tracking technique by multi-detector row computed tomography

Saline Flush After Rocuronium Bolus Reduces Onset Time and Prolongs Duration of Effect

Contrast medium administration and image acquisition parameters in renal CT angiography: what radiologists need to know

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