Evaluation of Renal Function Before and After Chemotherapy in Nasopharyngeal Cancer in Lombok

Abstract

Introduction
 Combination of chemotherapy and radiation are the treatment of choice in advance stage of nasopharyngeal cancer. Cisplatin-based chemotherapy is a regiment of choice in those cases. Several studies show that cisplatin-based chemotherapy affect renal function. Aims of the study to evaluate and compare the renal function before and after chemotherapy through comparing the blood urea nitrogen and creatinine serum level in patients with nasopharyngeal cancer who receive cisplatin and paclitaxel chemotherapy.
 Methods
 Design of this study is before and after using medical records data in West Nusa Tenggara General Hospital in Lombok.
 Result
 There were 33 patients who fulfill the inclusion and exclusion criteria in this study. Most of the patients are male with male and female ratio 3:1. The youngest patient age is eight years old, on the other hand, the oldest is 70 years old with the average age 46,6 years old. According to histopathology finding, on this study researcher didn't found WHO type I and most the patients were WHO type III (89,9 %). The mean blood urea nitrogen concentration before chemotherapy is 25,00 and after the treatment 33,33 with the p-value 0,01 with the paired t-test. On the other hand, creatinine serum level before and after chemotherapy consecutively 0,99 and 1,10. p-value 0,15, or there is no significant difference.
 Conclusion
 Blood urea nitrogen and creatinine serum are increase after cisplatin-based chemotherapy. However, only BUN has a significant difference.

Klasifikasi, Faktor Risiko, Tatalaksana dan Komplikasi Kanker Nasofaring

“…Kejadian kanker nasofaring di Indonesia yaitu sekitar 5,6 kasus per 100.000 penduduk dimana penemuan kasus baru sebanyak 15.000 kejadian di pertahunnya. Kasus baru untuk seluruh dunia tercatat sebanyak 129.079 kasus atau 0,7% dari keseluruhan kasus kanker dengan angka kematian mecapai 72.987 kematian (Kadriyan et al, 2019). Jika dilihat dari usia, kanker nasofaring jarang dijumpai pada sesorang yang berada di usia kurang dari 20 tahun (Pratama et al, 2017).…”

“…Penelitian yang dilakukan di Lombok pada tahun 2015 terhadap angka kejadian kanker nasofaring menunjukkan 48 pasien dengan karsinoma sel skuamosa yang tidak berdiferensiasi. Berdasarkan data Global Cancer Observatory (Globocan) pada tahun 2018 menyebutkan bahwa terdapat 129.079 kasus baru di seluruh dunia atau 0,7% dari semua kasus kanker dengan 72.987 kematian karena karsinoma nasofaring setiap tahunnya (Kadriyan, et al, 2019). Penelitian kanker nasofaring di Medan juga menyebutkan bahwa kelompok usia terbanyak untuk kasus kanker nasofaring adalah 50 sampai 59 tahun, sebesar 29,1%.…”