Evaluation of relationship between serum homocysteine and Vitamin B12 levels in oral submucous fibrosis patients using chemiluminescence immunoassay

Vanjani, Mukta Vijaykumar; Phulari, Rashmi G S; Rathore, Rajendrasinh

doi:10.4103/jomfp.jomfp_7_19

Cited by 5 publications

(4 citation statements)

References 17 publications

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“…Previous studies have demonstrated that folate and vitamin B12 status can affect the enzyme activity of MTHFR and methionine synthase, respectively [19,23]. In our current study, genotype TT participants had relatively low levels of folate, low vitamin B12 concentrations and higher diastolic blood pressure compared with genotype CC and genotype CT participants, which may partly mask the association between serum 5-MeTHF and Hcy [24,25]. We observed that vitamin B12 status modi ed but did not alter this association.…”

Section: Discussioncontrasting

confidence: 45%

Association Between Serum 5-methyltetrahydrofolate and Homocysteine in Chinese Hypertensive Participants With Different MTHFR C677T Polymorphisms: A Cross-sectional Study

Cheng

Shuai

Chen

et al. 2021

Preprint

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Background and aims: Clarifying the association between 5-methyltetrahydrofolate and homocysteine and the effect pattern of methylene tetrahydrofolate reductase (MTHFR C677T) may contribute to the management of homocysteine and may serve as a significant reference for a randomized controlled trial of 5-methyltetrahydrofolate intervention. This study aimed to reveal the association between these two biochemical indices. Methods: Study population was drawn from the baseline data of the China Stroke Primary Prevention Trial (CSPPT), including 2,328 hypertensive participants. 5-methyltetrahydrofolate and homocysteine were determined by stable-isotope dilution liquid chromatography-tandem mass spectrometry and automatic clinical analyzers, respectively. MTHFR C677T polymorphisms were detected using TaqMan assay. Multiple linear regression was performed to evaluate the association between serum 5-methyltetrahydrofolate and homocysteine. Results: There was a significant inverse association between 5-methyltetrahydrofolate and homocysteine when 5-methyltetrahydrofolate was B 10 ng/mL, and this association was modified by MTHFR C677T (per 1-ng/mL increment; All: a = -0.50, P < 0.001; CC: c = -0.14, P = 0.087; CT: k = -0.20, P = 0.011; TT: g = -1.19, P < 0.001). Moreover, the decline in trend in genotype TT participants was stronger than in genotype CC participants (P for difference < 0.001) and genotype CT participants (P for difference < 0.001), while there was no significant difference between genotype CC and genotype CT participants (P for difference = 0.757). Conclusions: Our data showed a non-linear association between serum homocysteine and 5-methyltetrahydrofolate among Chinese hypertensive adults, however, it could be inversely linearly fitted when serum 5-methyltetrahydrofolate was r 10 ng/mL , and this association was modified by MTHFR C677T.

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Section: Discussioncontrasting

confidence: 45%

Association Between Serum 5-methyltetrahydrofolate and Homocysteine in Chinese Hypertensive Participants With Different MTHFR C677T Polymorphisms: A Cross-sectional Study

Cheng

Shuai

Chen

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…Previous studies have demonstrated that folate and vitamin B12 status can affect the enzyme activity of MTHFR and methionine synthase, respectively [22,26]. In our current study, genotype TT participants had relatively low levels of folate, low vitamin B12 concentrations and higher diastolic blood pressure compared with genotype CC and genotype CT participants, which may partly mask the association between serum 5-MeTHF and Hcy [27,28]. We observed that vitamin B12 status modified but did not alter this association.…”

Section: Discussioncontrasting

confidence: 43%

Association between serum 5-methyltetrahydrofolate and homocysteine in Chinese hypertensive participants with different MTHFR C677T polymorphisms: a cross-sectional study

Cheng

Liu

Chen

et al. 2022

Nutr J

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Background and aims Clarifying the association between 5-methyltetrahydrofolate and homocysteine and the effect pattern of methylene tetrahydrofolate reductase (MTHFR C677T) may contribute to the management of homocysteine and may serve as a significant reference for a randomized controlled trial of 5-methyltetrahydrofolate intervention. This study aimed to reveal the association between these two biochemical indices. Methods Study population was drawn from the baseline data of the China Stroke Primary Prevention Trial (CSPPT), including 2328 hypertensive participants. 5-methyltetrahydrofolate and homocysteine were determined by stable-isotope dilution liquid chromatography-tandem mass spectrometry and automatic clinical analyzers, respectively. MTHFR C677T polymorphisms were detected using TaqMan assay. Multiple linear regression was performed to evaluate the association between serum 5-methyltetrahydrofolate and homocysteine. Results There was a significant inverse association between 5-methyltetrahydrofolate and homocysteine when 5-methyltetrahydrofolate was ≤ 10 ng/mL, and this association was modified by MTHFR C677T (per 1-ng/mL increment; All: β = − 0.50, P < 0.001; CC: β = − 0.14, P = 0.087; CT: β = − 0.20, P = 0.011; TT: β = − 1.19, P < 0.001). Moreover, the decline in trend in genotype TT participants was stronger than in genotype CC participants (P for difference < 0.001) and genotype CT participants (P for difference < 0.001), while there was no significant difference between genotype CC and genotype CT participants (P for difference = 0.757). Conclusions Our data showed a non-linear association between serum homocysteine and 5-methyltetrahydrofolate among Chinese hypertensive adults, however, it could be inversely linearly fitted when serum 5-methyltetrahydrofolate was ≤ 10 ng/mL, and this association was modified by MTHFR C677T.

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“…In addition, iron is essential for the normal function of oral epithelial cells and vitamin B12 and folic acid play important roles in DNA synthesis and cell division. Oral epithelial atrophy in patients with hematinic deficiency may explain why some patients with hematinic deficiency tend to have RAS (Lin, et al, 2017;Vanjani, Phulari, & Rathore, 2019).…”

Section: Discussionmentioning

confidence: 99%

“…Atrophic glossitis as well as the presence of severe ulcerative lesions of the oral mucosa can cause a burning sensation and pain when the patient eats salty and spicy foods. This can cause difficulty eating and reduced intake of incoming food, causing anemia and haematinic deficiency (Vanjani, Phulari, & Rathore, 2019).…”

Section: Discussionmentioning

confidence: 99%

Recurrent Aphthous Stomatitis: A Review of Hematinic Deficiency Factor

Nur’aeny

2024

ejtas

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Background: Recurrent aphthous stomatitis (RAS) is a common disease of the oral mucosa, with a prevalence of 5-25% in some population in the world. The etiology of RAS is uncertain, but there are several predisposing factors including nutritional factors due to hematinic deficiency, substances that help in the process of erythropoiesis such as vitamin B12, folic acid, and iron. Aims: This literature study aims to present the role of hematinic deficiency in the pathogenesis RAS. Method of review: This article was created by searching the PubMed and Scopus databases. Results: five studies with the majority using a cross-sectional method and using a sample of 186 to 705 subjects indicate that hematinic deficiency is one of the factors associated with RAS. Three studies state that the RAS group with hematinic deficiency is also associated with anemia, such as microcytic anemia, normocytic anemia, macrocytic anemia, pernicious anemia, and iron deficiency anemia. All studies state that iron deficiency is more common than vitamin B12 and folic acid deficiencies in patients with RAS. Hematinic deficiency causes a decrease capacity of blood to transport oxygen to the oral mucosa, resulting in epithelial atrophy, and this condition is highly susceptible to developing RAS. Conclusion: Hematinic deficiency plays a role in the pathogenesis of RAS.

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Evaluation of relationship between serum homocysteine and Vitamin B12 levels in oral submucous fibrosis patients using chemiluminescence immunoassay

Cited by 5 publications

References 17 publications

Association Between Serum 5-methyltetrahydrofolate and Homocysteine in Chinese Hypertensive Participants With Different MTHFR C677T Polymorphisms: A Cross-sectional Study

Association Between Serum 5-methyltetrahydrofolate and Homocysteine in Chinese Hypertensive Participants With Different MTHFR C677T Polymorphisms: A Cross-sectional Study

Association between serum 5-methyltetrahydrofolate and homocysteine in Chinese hypertensive participants with different MTHFR C677T polymorphisms: a cross-sectional study

Recurrent Aphthous Stomatitis: A Review of Hematinic Deficiency Factor

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