Evaluation of QuickVue influenza A+B rapid test for detection of pandemic influenza A/H1N1 2009

Velasco, John Mark; Montesa-Develos, Maribel L.; Jarman, Richard G.; Lopez, Ma. Nila; Gibbons, Robert V.; Valderama, Maria Theresa; Yoon, In-Kyu

doi:10.1016/j.jcv.2010.03.010

Cited by 22 publications

(17 citation statements)

References 21 publications

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“…Factors that can impact RIDT performance include specimen type, 7 , 14 time of specimen collection after onset of illness, 7 duration of specimen storage, and transportation conditions. We were not able to compare RIDT performance among different specimen types because 98% of the specimens included in this study were NP swabs.…”

Section: Discussionmentioning

confidence: 99%

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Detection of 2009 pandemic influenza A(H1N1) virus Infection in different age groups by using rapid influenza diagnostic tests

Gao¹,

Loring²,

Laviolette³

et al. 2011

Influenza Resp Viruses

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Please cite this paper as: Gao et al. (2011) Detection of 2009 pandemic influenza A(H1N1) virus Infection in different age groups by using rapid influenza diagnostic tests. Influenza and Other Respiratory Viruses 6(3), e30–e34. Background The performance of rapid influenza diagnostic tests (RIDTs) in detecting influenza A(H1N1) 2009 has varied widely. Evaluations of RIDTs among infected individuals across all age groups have not been described in depth. Objectives Determine RIDT clinical sensitivity in comparison with influenza detection using real‐time RT‐PCR among patients infected with influenza A(H1N1) 2009 across all age groups. Study design This study analyzed respiratory specimens received by the New Hampshire Public Health Laboratories (NHPHL) from September 1, 2009, through December 31, 2009. RIDT performance was evaluated among different age groups of patients determined to be infected with influenza A (H1N1) 2009, and the association between age and RIDT sensitivity was determined. Results Of 1373 specimens examined, 269 tested positive for influenza A(H1N1) 2009 by real‐time RT‐PCR (rRT‐PCR) and had RIDT results available. Overall clinical sensitivity and specificity of RIDTs were 53·9 and 98·5%, respectively. By age group, clinical sensitivity was 85·7% in patients <2 years old, 60·3% in patients between 2‐ and 39 years old, and 33·3% in patients aged 40 and older. Logistic regression analysis indicated that increasing age was negatively associated with RIDT performance. Conclusion Rapid influenza diagnostic test sensitivity decreased significantly with increasing age. Findings from this study may impact a clinician’s interpretation of RIDT test results and ultimately have implications in clinical decision‐making.

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Section: Discussionmentioning

confidence: 99%

“…Previous studies have shown that RIDT sensitivity was correlated with increasing viral titer 2 , 6 , 7 and that higher RIDT sensitivity was found in younger age groups than older groups 3 , 5 , 8 , 9 . However, these studies were conducted either in pediatric patients or with a small sample of older patients.…”

Section: Introductionmentioning

confidence: 99%

Detection of 2009 pandemic influenza A(H1N1) virus Infection in different age groups by using rapid influenza diagnostic tests

Gao¹,

Loring²,

Laviolette³

et al. 2011

Influenza Resp Viruses

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“…1e3 For example, the QuickVue Influenza AþB Test (Quidel, San Diego, CA, USA), which is an enzyme-linked immunosorbent assay (ELISA)-based kit and detects both influenza virus A and influenza virus B, has shown a sensitivity of 0.63 and a specificity of 0.96 with the 2009 pandemic influenza A (H1N1) infection. 4 Most of these rapid tests use monoclonal antibodies against nucleoprotein encoded by influenza A viruses. 5 In this study, we tested a new 2009 pandemic influenza A (H1N1)-specific ELISA 6 designed and manufactured by Xiamen University, China, on human samples.…”

Section: Introductionmentioning

confidence: 99%

A highly specific ELISA for diagnosis of 2009 influenza A (H1N1) virus infections

Lu¹,

Chang²,

Chen³

et al. 2012

Journal of the Formosan Medical Association

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“…These tests are widely used in physician offices and hospital laboratories because of their simplicity and speed. RIATs are well known to have poor sensitivity, including for the influenza A (H1N1) 2009 virus (1,4,5,(7)(8)(9)(10). Few studies have reported poor specificity of RIATs (8), and the widely held view is that the specificity and positive predictive value (PPV) of these tests are relatively high when they are performed during periods of high disease prevalence.…”

mentioning

confidence: 99%

“…Most studies have reported relatively high QuickVue RIAT specificities of 84 to 100% and PPV of 84 to 97% for influenza A viruses, including the H1N1 2009 pandemic subtype (4,7,9,10). One recent study reported QuickVue specificity of 46.4% during the influenza A (H1N1) 2009 pandemic, but according to the authors, data may have been skewed by testing algorithms (8).…”

mentioning

confidence: 99%

Poor Positive Accuracy of QuickVue Rapid Antigen Tests during the Influenza A (H1N1) 2009 Pandemic

Stevenson

Loeffelholz

2010

J Clin Microbiol

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Evaluation of QuickVue influenza A+B rapid test for detection of pandemic influenza A/H1N1 2009

Cited by 22 publications

References 21 publications

Detection of 2009 pandemic influenza A(H1N1) virus Infection in different age groups by using rapid influenza diagnostic tests

Detection of 2009 pandemic influenza A(H1N1) virus Infection in different age groups by using rapid influenza diagnostic tests

A highly specific ELISA for diagnosis of 2009 influenza A (H1N1) virus infections

Poor Positive Accuracy of QuickVue Rapid Antigen Tests during the Influenza A (H1N1) 2009 Pandemic

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