Evaluation of Quantitative Criteria for Glioma Grading With Static and Dynamic 18F-FDopa PET/CT

Nioche, Christophe; Soret, Marine; Gontier, Éric; Lahutte, M.; Dutertre, Guillaume; Dulou, R.; Laurent, Césari; Guillevin, Rémy; Fœhrenbach, H.; Buvat, Irène

doi:10.1097/rlu.0b013e318279fd5a

Cited by 34 publications

(44 citation statements)

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“…Similarly, in the study published by Schiepers et al, the tumor FDOPA uptake peak activity was reached around 20 min p.i [5]. In two more recent studies, the TACs of tumor FDOPA uptake peaked earlier at 8-10 min p.i [9,13]. However, the EANM/EANO/RANO practice guidelines/SNMMI procedure standards for imaging of gliomas using PET recently recommended a 10-20 min image acquisition performed 10-30 min p.i [8].…”

Section: Discussionsupporting

confidence: 57%

“…For routine clinical interpretation, semiquantitative measures of tumor activity uptake values are calculated [8]. However, kinetic parameters obtained through dynamic acquisition might provide further details about tumor characterization [5,9]. For instance, information regarding tumor aggressiveness from FDOPA PET/CT could have utility in guiding biopsy [10], and potentially improve patient management with dose-escalation using intensity-modulated radiotherapy in patients with glioma [10,11].…”

Section: Introductionmentioning

confidence: 99%

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Optimization of time frame binning for FDOPA uptake quantification in glioma

et al. 2020

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Introduction 3,4-dihydroxy-6-[18F]fluoro-L-phenylalanine (FDOPA) uptake quantification in glioma assessment can be distorted using a non-optimal time frame binning of time-activity curves (TAC). Under-sampling or over-sampling dynamic PET images induces significant variations on kinetic parameters quantification. We aimed to optimize temporal time frame binning for dynamic FDOPA PET imaging. Methods Fourteen patients with 33 tumoral TAC with biopsy-proven gliomas were analysed. The mean SUVmax tumor-to-brain ratio (TBRmax) were compared at 20 min and 35 min postinjection (p.i). Five different time frame samplings within 20 min were compared: 11x10sec-6x15sec-5x20sec-3x300sec; 8x15sec-2x30sec-2x60sec-3x300sec; 6x20sec-8x60sec-2x300sec; 10x30sec-3x300sec and 4x45sec-3x90sec-5x150sec. The reversible singletissue compartment model with blood volume parameter (VB) was selected using the Akaike information criterion. K1 values extracted from 1024 noisy simulated TAC using Monte Carlo method from the 5 different time samplings were compared to a target K1 value as the objective, which is the average of the K1 values extracted from the 33 lesions using an imaging-derived input function for each patient. Results The mean TBRmax was significantly higher at 20 min p.i. than at 35 min p.i (respectively 1.4 +/-0.8 and 1.2 +/-0.6; p <0.001). The target K1 value was 0.161 mL/ccm/min. The 8x15sec-2x30sec-2x60sec-3x300sec time sampling was the optimal time frame binning. K1 values extracted using this optimal time frame binning were significantly different with K1 values extracted from the other time frame samplings, except with K1 values obtained using the 11x10sec-6x15sec-5x20sec-3x300sec time frame binning.

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Section: Discussionsupporting

confidence: 57%

Section: Introductionmentioning

confidence: 99%

Optimization of time frame binning for FDOPA uptake quantification in glioma

et al. 2020

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“…In e we report the PET/MRI fusion imaging and in f the T2-weighted MRI FDOPA in PBT according to their grade of malignancy. While the wash out of [ 18 F] FDOPA in normal tissues is relatively slow (with the concentration of [ 18 F] FDOPA over time being quietly constant), high-grade tumors are usually characterized by a rapid wash out as compared to low grades [21,22]. Another possible explanation of the differences in SUVr values could be sought in the different timings in the acquisition of PET scans in our study (15 min) as compared to that of Karunanithi (15-30 min) [18].…”

Section: Discussionmentioning

confidence: 99%

Overall survival and progression-free survival in patients with primary brain tumors after treatment: is the outcome of [18F] FDOPA PET a prognostic factor in these patients?

et al. 2019

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Aim To investigate the progression-free survival (PFS) and the overall survival (OS) in a population affected by primary brain tumors (PBT) evaluated by [ 18 F]-l-dihydroxyphenylalanine ([ 18 F] FDOPA) positron emission tomography/computed tomography (PET/CT). Materials and methods 133 subjects with PBT (65 women and 68 men, mean age 45 ± 10 years old) underwent 18 F FDOPA PET/CT after treatment. Of them, 68 (51.2%) were Grade II, 34 (25.5%) were Grade III and 31 (23.3%) were Grade IV. PET/CT was scored as positive or negative and standardized uptake value ratio (SUVr) was calculated as the ratio between SUVmax of the lesion vs. that of the background. Patients have been observed for a mean of 24 months. Results The outcome of [ 18 F] FDOPA PET/CT scan was significantly related to the OS and PFS in Grade II gliomas. In Grade II PBT, the OS proportions at 24 months were 100% in subjects with a negative PET/CT scan and 82% in those with a positive scan. Gehan-Breslow-Wilcoxon test showed a significant difference in the OS curves (P = 0.03) and the hazard-ratio was equal to 5.1 (95% CI of ratio 1.1-23.88). As for PFS, the proportion at 24 months was 90% in subjects with a negative PET/CT scan and 58% in those with a positive scan. Gehan-Breslow-Wilcoxon test showed a significant difference in the OS curves (P = 0.007) and the hazard-ratio was equal to 4.1 (95% CI of ratio 1.3-8). We did not find any significant relationship between PET outcome and OS and PFS in Grade III and IV PBT. Conclusions A positive [ 18 F] FDOPA PET/CT scan is related to a poor OS and PFS in subjects with low-grade PBT. This imaging modality could be considered as a prognostic factor in these subjects.Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

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“…However, reports are conflicting. Studies by Fueger et al [88], Pafundi et al [89] and Nioche et al [90] reported that FDOPA PET could discriminate between high and low-grade primary glioma. However, as part of their study, Chen et al found no significant difference in FDOPA uptake between the two classes.…”

Section: -[ 18 F]fluoro-dihydroxy-l-phenylalanine (Fdopa)mentioning

confidence: 99%