Evaluation of psychological and physiological predictors of fatigue in patients with COPD

Lewko, Agnieszka; Bidgood, Penelope; Garrod, Rachel

doi:10.1186/1471-2466-9-47

Cited by 54 publications

(69 citation statements)

References 40 publications

(48 reference statements)

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“…Furthermore, the prevalence, experience (frequency, duration and severity) and the number of patients with no, moderate and severe fatigue was similar in men and women which is in agreement with previous studies [76][77] .…”

Section: Factors Associated With Low Physical Activitysupporting

confidence: 80%

The relationship between physical function and experience of fatigue in patients with chronic obstructive pulmonary disease

Tödt¹

2014

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Background Chronic Obstructive Pulmonary Disease (COPD) is increasing throughout the world and most rapidly among women. COPD is characterized by a progressive loss of physical functions. The reason for this is multi-factorial and include not only lung related deficiencies but also several systemic consequences and symptoms of which several are potential restrictors of physical function. The relationship between physical function and symptoms are not clear, especially not among women with COPD. Aim The overall aim of this thesis was to illuminate the relationship between two dimensions of physical function (physical activity and physical capacity) and experience of fatigue. The specific aims were to explore factors associated with low physical activity and to examine experience of fatigue and its relationship to physical capacity and disease severity in men and women with COPD. Methods A cross-sectional study was conducted including 121 patients (67 women) with stable COPD and mean age of 67 (+/-7) years. Physical activity was measured with the International Physical Activity Questionnaire short form. Physical capacity included assessment of lung function (dynamic spirometry), exercise capacity (the 6-minute walk distance [perceived dyspnoea and leg fatigue in connection to the test]) and muscle strength (the Timed Stands Test and grip strength). Fatigue was assessed with structured questions covering the frequency, duration and severity of fatigue the previous month and patients were categorized as those with no fatigue, moderate fatigue or severe fatigue. Data about other symptoms (dyspnoea, anxiety and depression), symptom burden (Memorial Symptom Assessment Scale), fat and fat free mass (bio-impedance analysis) and smoking history was collected. Results Forty-two percent of the patients reported a low physical activity level. A majority of the patients reported experience of fatigue the previous month, 52% moderate fatigue and 25% severe fatigue. Low physical activity was associated with severe fatigue, worse exercise capacity and a higher amount of smoking. There were no differences in experience of fatigue between men and women. Men with fatigue had worse physical capacity and disease severity compared to men without fatigue. Women with fatigue had comparable physical capacity and disease severity to women without fatigue except for a higher perceived leg fatigue after the exercise capacity test. Multiple logistic regression analysis showed that exercise capacity and disease severity were associated with fatigue in both men and women but in women, leg fatigue was also strongly associated with the presence of fatigue. Conclusions Severe fatigue, worse exercise capacity and a higher amount of smoking were independently associated with low PA. This result suggests that patients with severe fatigue might need specific strategies to become more physically active. Presence of fatigue was associated with exercise capacity and disease severity in both men and women. In addition, in women leg fatigue was strongly a...

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Section: Factors Associated With Low Physical Activitysupporting

confidence: 80%

The relationship between physical function and experience of fatigue in patients with chronic obstructive pulmonary disease

Tödt¹

2014

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“…Existing literature has shown that COPD patients report greater fatigue than the general population [35][36][37]. However, the severity of fatigue between COPD patients and other clinical populations has rarely been examined.…”

Section: Discussionmentioning

confidence: 99%

Fatigue in COPD: association with functional status and hospitalisations

et al. 2012

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This study aimed to examine the importance of fatigue as a clinical indicator in chronic obstructive pulmonary disease (COPD), by analysing its relationship with COPD severity and ability to predict risk of hospitalisation, and by comparing the intensity of fatigue in stable COPD patients with levels of fatigue reported by patients with other chronic conditions.We studied 100 consecutive patients attending assessment clinics before pulmonary rehabilitation. Both questionnaire and physiological data were collected. Partial correlations, multiple linear regressions and Cox proportional hazard models/negative binomial regressions were used to address the research questions.A significant relationship existed between fatigue and COPD severity. Fatigue reports predicted future hospitalisation risk. Compared to the lowest third of patients, the third of patients reporting the most intense fatigue showed a 10-fold increase in risk of hospitalisation (fatigue experiences hazard ratio (HR) 10.2, 95% CI 2.66-38.86; fatigue impacts HR 10.7, 95% CI 2.76-41.65). Our COPD sample reported fatigue scores of similar intensity to colorectal cancer patients and HIV-positive patients.While fatigue is significantly related to COPD functional severity, fatigue data also capture independent information. Fatigue reports can contribute to predictions of hospitalisation risk.

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“…Fatigue has been defined as "the multidimensional sensation of tiredness that the individual experiences when perceiving the reduced capacity to function normally" and it often varies with respect to daily pattern, triggers or contributing factors, and responsiveness to interventions (Kapella et al, 2006). In contrast with a prevalence rate of 18.3%-25% in the general population (Lewko et al, 2009;Pawlikowska et al, 1994) fatigue is "almost always" experienced by 43%-58% of persons with COPD ( Kinsman et al, 1983;Walke et al,2007).…”

Section: Introductionmentioning

confidence: 91%

“…The overall score of fatigue is calculated by adding all subscales, so that the overall score ranges from 20 to 100. A higher score implies more severe fatigue (Breslin et al, 1998;Lewko et al 2009;Meek & Lareau, 2003;Oh et al, 2004).…”

Section: Multidimentional Fatigue Inventory (Mfi);mentioning

confidence: 99%