Evaluation of proliferative potential in oral lichen planus and oral lichenoid lesions using immunohistochemical expression of p53 and Ki67

Acay, Renata Rodrigues; Felizzola, Cláudia Ronca; Araújo, Ney Soares de; Sousa, Suzana Orsini Machado de

doi:10.1016/j.oraloncology.2005.09.012

Cited by 59 publications

(63 citation statements)

References 22 publications

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“…It is also known th at OLP can u nd ergo malignant transformation and become SCC, although this event is not very common 11,24,25,47,48) . However, the frequency of this event has been long debated.…”

Section: Discussionmentioning

confidence: 99%

Human Papillomavirus in Oral Lichen Planus of Japanese Patients

Kato

Kawai

Isomura

et al. 2015

J. Hard Tissue Biology.

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Oral lichen planus (OLP) can undergo malignant transformation and become squamous cell carcinoma (SCC). Oral infection with human papillomavirus (HPV) is associated with a significant risk of developing oral cancer. Although HPV DNA is detected more often in OLP tissue than in normal oral mucosa, there is as yet no firm evidence that HPV is a causative factor of malignant transformation in OLP. The objective of the present investigation was to assess HPV-genotype distribution in OLPs of Japanese patients and additionally to clarify the relationship between malignant transformation in OLP and HPV infection using PCR, in situ hybridization, and immunohistochemistry. DNA of 200 formalin-fixed, paraffin-embedded biopsy and surgical specimens of OLP was extracted. HPV infection was first detected by PCR using consensus HPV primers. Positive PCR samples were then further analyzed by PCR using HPV type-specific primers (HPV-6, -11, -16, -18 and -33). Eighty-three samples (41.5 %) out of the total 200 OLP specimens analyzed were HPV positive. In the HPV type-specific PCR assay, the most frequent type of HPV was HPV-16 (25.5 %), which is a high-risk type of HPV that is associated with malignant disorders and is often detected in SCC. The highest HPV-16 positive rate was obtained for the erosive type of OLP (28.3 %). Positive staining for HPV DNA by in situ hybridization was observed in the nuclei of cells in all layers of the epithelium in all HPV PCR positive samples. Immunohistochemically, nuclei of cells in the upper layer of the epithelium in all HPV PCR positive samples stained positive for the anti-HPV antibody. These results indicated that HPV-16 was often present in OLP of Japanese patients, especially in the erosive type of OLP, and suggested that HPV infection is a risk factor for malignant transformation in OLP lesions.

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Section: Discussionmentioning

confidence: 99%

Human Papillomavirus in Oral Lichen Planus of Japanese Patients

Kato

Kawai

Isomura

et al. 2015

J. Hard Tissue Biology.

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“…It has a prolonged clinical course that can persist for many years despite various treatments (1,2). Patients with OLP carry an increased risk of developing oral squamous cell carcinomas (OSCC), which led the WHO to classify OLP as a potentially malignant disorder (3).…”

Section: Introductionmentioning

confidence: 99%

Podoplanin and ABCG2: Malignant Transformation Risk Markers for Oral Lichen Planus

Peng

Liu

Zhou

et al. 2010

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: Oral lichen planus (OLP) is a potentially malignant disorder associated with an increased risk for oral cancer. The purpose of this study was to determine protein expression of podoplanin and ATP-binding cassette, G2 subfamily (ABCG2) in patients with OLP and evaluate their use as biomarkers for OLP malignant transformation risk.Methods: Podoplanin and ABCG2 expressions were determined in samples from 110 patients with untransformed OLP and 9 patients with malignant transformed OLP (mean follow-up of 5.1 years). We compared podoplanin expression, ABCG2 expression, and clinicopathologic parameters between the two groups.Results: Podoplanin expression was observed in 48 of 110 (43.6%) cases of untransformed OLP and in 8 of 9 (88.9%) cases of transformed OLP. ABCG2 expression was found in 23 of 110 (20.9%) cases of untransformed OLP and in 6 of 9 (66.7%) cases of transformed OLP. Multivariate regression analysis revealed that podoplanin or ABCG2 expression was associated with 17.13-fold [95% confidence interval (95% CI), 1.71-171.22; P = 0.016] or 6.04-fold (95% CI, 1.20-30.36; P = 0.029) increased risk of malignant transformation, respectively. The risk of OLP malignant transformation was considerably higher with coexpression of podoplanin and ABCG2 than without coexpression of podoplanin and ABCG2 (odds ratio, 25.24; 95% CI, 4.48-142.27; P < 0.001).Conclusions: The expressions of podoplanin and ABCG2 in OLP were significantly associated with malignant transformation risk.Impact: Our data suggested that podoplanin and ABCG2 may be used as biomarkers for risk assessment of oral malignant transformation in patients with OLP. Cancer Epidemiol Biomarkers Prev; 19(3); 844-9. ©2010 AACR.

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“…Il est probable que le LPB idiopa- [31] et les données obtenues sur l'une d'elle permettent d'illustrer des éléments physiopathologiques de l'autre [53] . Enfin, plusieurs études s'intéressant à la relation entre le LPB et l'état psychique montrent que le stress et la dépression représentent des facteurs favorisant le développement du LPB [55] .…”

Section: Lpb « Induit » Ou Associé à D'autres Maladiesunclassified

Lichen plan buccal : histoire naturelle et transformation maligne

Lysitsa¹,

Najm²,

Lombardi³

et al. 2007

Med Buccale Chir Buccale

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RÉSUMÉLe lichen plan est une dermatose cutanéo-muqueuse inflammatoire chronique qui touche toutes les régions de la muqueuse buccale. Il y a quatre phases dans l'évolution du lichen plan buccal (LPB) : la phase initiale, la phase d'état, la phase tardive et l'état post-lichénien. SUMMARY Oral lichen planus (OLP) is a chronic inflammatory dermato-mucosal disease which gets all the regions of the buc

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Evaluation of proliferative potential in oral lichen planus and oral lichenoid lesions using immunohistochemical expression of p53 and Ki67

Cited by 59 publications

References 22 publications

Human Papillomavirus in Oral Lichen Planus of Japanese Patients

Human Papillomavirus in Oral Lichen Planus of Japanese Patients

Podoplanin and ABCG2: Malignant Transformation Risk Markers for Oral Lichen Planus

Lichen plan buccal : histoire naturelle et transformation maligne

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