2010
DOI: 10.1590/s1413-86702010000300009 View full text |Buy / Rent full text
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Abstract: Background: Fever as a common presenting complaint in pediatric patients can be due to various causes. Differentiating bacterial infection from other causes is important because the prompt use of antibiotics is critical in bacterial infection. Traditional markers of infection such as BT and WBC count may be unspecifi c and culture may be late or absent. CRP and Procalcitonin (PCT) have been considered to evaluate the evolution of infections and sepsis in patients presenting with SIRS. Neopterin has also been p… Show more

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“…In limited numbers of pediatric studies, Neely et al [20] indicated that PCT had a sensitivity of 42% for early diagnosis of sepsis in 20 children with burns. Pourakbari et al [21] concluded that rapid PCT test was superior to neopterin for anticipating bacterial infection in pediatric patients with bacterial infection. Mann et al [8] indicated that PCT may be helpful to diagnose sepsis.…”
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“…The conventional diagnosis of K. pneumoniae infection is derived from cultures of samples obtained from the site of suspected infection, which can take several days and may not provide reliable information since blood cultures can have high contamination rates. There are other clinical methods to identify infection, such as monitoring of body temperature, white blood cell count, erythrocyte sedimentation rate, and cytokine reactions, but none of these is a specific response to infection or able to differentiate bacterial infection from inflammation (3). In addition, the emergence of K. pneumoniae resistance to antimicrobial drug is well documented (4).…”
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“…1,3 Procalcitonin (PCT) has been used commonly, as its diagnostic value is relatively well described, although it is not an ideal sepsis marker. 5 Another marker of potential value in the diagnosis of infection is neopterin (NPT), however its value in sepsis has not yet been sufficiently evaluated and NPT determination has not been introduced as a routine parameter. 4 According to the current publications about soluble CD163 (sCD163), one can conclude that it is a marker which correlates with common markers of sepsis.…”
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“…The PCT level starts to rise within 6 h after an inflammation process is initiated, reaches maximum values between 12 and 48 h, and then returns to normal values if the infection agent has been eradicated. 5 A persisting high or continuously increasing concentration of PCT suggests a systemic inflammatory reaction or septic complication after surgery. PCT concentration remains low in local infections without systemic response.…”
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