Diagnostic usefulness of sCD163, procalcitonin and neopterin for sepsis risk assessment in critically ill patients

Sapa, Agnieszka; Rak, Alina; Wybieralska, Magdalena; Machoń, Jakub; Krzywonos‐Zawadzka, Anna; Zawadzki, Kamil; Wełna, Marek; Woźniak, Mieczysław

doi:10.17219/acem/63251

Cited by 9 publications

(5 citation statements)

References 20 publications

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“…In other words, sTREM-1 and sCD163 are not only involved in the process of pathological changes of the heart, but also closely related to the process of inflammation caused by infection. 27,28 Finally, in this study, the predictive value of the three indicators for the prognosis of patients with CHF complicated with pulmonary infection is evaluated, and the results show that the three indicators all have favorable predictive value for the poor prognosis of patients, among which the area of sCD163 AUC is the largest.…”

Section: A H E a D O F P R I N Tmentioning

confidence: 92%

Pathogenic characteristics of pulmonary infection in hospitalized patients with chronic heart failure and diagnostic value of sTREM-1, sCD163, and sTWEAK

Zheng¹

2022

Pak J Med Sci

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Objective: To investigate the pathogenic characteristics of pulmonary infection in hospitalized patients with chronic heart failure as well as the diagnostic value of soluble myeloid cell expression triggering receptor-1 (sTREM-1), soluble CD163 (sCD163) and soluble tumor necrosis factor-like weak inducing factor (sTWEAK). Methods: A total of 72 patients with pulmonary infection who were hospitalized with chronic heart failure from December 2017 to December 2019 in the Department of Cardiology of Hebei Baoding Huaying Hospital of Traditional Chinese Medicine, China, were selected as the infection group, seventy-two patients without pulmonary infection who were hospitalized with chronic heart failure were selected as the non-infection group, and 50 healthy subjects who underwent physical examination in the hospital during the same period were selected as the control group. The distribution characteristics of pathogens in the infection group were statistically analyzed. The levels of sTREM-1, S CD163 and STweak in serum of patients with different infection severity and different cardiac function grades were compared among the three groups. Receiver operating characteristic curve (ROC) was utilized to evaluate the predictive value of the three indicators for the adverse prognosis of patients in hospital. Results: A total of 76 strains of pathogens were cultured from two hospitalized patients with pulmonary infection of chronic heart failure, among which 43 strains (56.58%) were gram-negative bacteria, 29 strains (38.15%) were gram-positive bacteria, and four strains (5.26%) were fungi. The levels of sTREM-1 and sCD163 in the control group, non-infection group and infection group were gradually increased (p<0.05), while there was no difference in sTWEAK between the infection group and the non-infection group (p>0.05). In the infection group, the expression levels of sTREM-1 and sCD163 increased with the severity of infection, with statistically significant differences (p<0.05), while there was no statistically significant difference in the expression level of sTWEAK among different infection severity (p>0.05). The higher the cardiac function grade of patients in the infection group, the higher the levels of sTREM-1 and sCD163, and the lower the level of sTWEAK, with a statistical significance (p<0.05). ROC analysis results showed that the serum sTREM-1, sCD163, and sTWEAK levels for the poor prognosis of patients with CHF combined with lung infection had areas under the curve of 0.864, 0.870, and 0.822, respectively, and the 95% CI values were 0.787-0.941, 0.795-0.945 and 0.733-0.910, respectively, all p<0.001. Conclusions: Pulmonary infection in hospitalized patients with chronic heart failure is mainly caused by gram-negative bacteria. Detection of sTREM-1, sCD163, and sTWEAK levels is of certain value in judging the condition and prognosis, which is worthy of clinical promotion. doi: https://doi.org/10.12669/pjms.38.3.4758 How to cite this:Zheng F. Pathogenic characteristics of pulmonary infection in hospitalized patients with chronic heart failure and diagnostic value of sTREM-1, sCD163, and sTWEAK. Pak J Med Sci. 2022;38(3):---------. doi: https://doi.org/10.12669/pjms.38.3.4758 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Section: A H E a D O F P R I N Tmentioning

confidence: 92%

Pathogenic characteristics of pulmonary infection in hospitalized patients with chronic heart failure and diagnostic value of sTREM-1, sCD163, and sTWEAK

Zheng¹

2022

Pak J Med Sci

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“…Normal fetal lungs development is crucial for newborn survival (Figure 1). There are few invasive methods predicting proper fetal lung development, for example, lecithin/sphingomyelin ratio or phosphatidylglycerol but these methods seems impractical from a clinical point of view 1 . Invasiveness indicates a risk of postprocedural complication, as in every case amniotic fluid must be obtained.…”

Section: Figurementioning

confidence: 99%

“…There are few invasive methods predicting proper fetal lung development, for example, lecithin/sphingomyelin ratio or phosphatidylglycerol but these methods seems impractical from a clinical point of view. 1 Invasiveness indicates a risk of postprocedural complication, as in every case amniotic fluid must be obtained. That is why many scientists try to rule out noninvasive methods to reach the same or even better predicting results.…”

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confidence: 99%

Prenatal ultrasound assessment of fetal lung development in normal and complicated by fetal and maternal diseases pregnancy

Słodki

Sylwestrzak

2023

J of Clinical Ultrasound

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“…PCT does appear to have an advantage when used in populations acute kidney injury (AKI), with Nakamura and co-workers [66] demonstrating that PCT is more accurate than presepsin for diagnosing sepsis in AKI patients. Other studies have indicated a more modest performance when using PCT for sepsis diagnosis, with AUCs ranging from 0.7 to 0.9 [67][68][69]. There is also conflicting evidence on the possible correlation of PCT with SOFA for predicting organ dysfunction.…”

Section: Adults Intensive Care Units (Icu)mentioning

confidence: 99%

Biomarkers for Point-of-Care Diagnosis of Sepsis

2020

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Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host response to infection. In 2017, almost 50 million cases of sepsis were recorded worldwide and 11 million sepsis-related deaths were reported. Therefore, sepsis is the focus of intense research to better understand the complexities of sepsis response, particularly the twin underlying concepts of an initial hyper-immune response and a counter-immunological state of immunosuppression triggered by an invading pathogen. Diagnosis of sepsis remains a significant challenge. Prompt diagnosis is essential so that treatment can be instigated as early as possible to ensure the best outcome, as delay in treatment is associated with higher mortality. In order to address this diagnostic problem, use of a panel of biomarkers has been proposed as, due to the complexity of the sepsis response, no single marker is sufficient. This review provides background on the current understanding of sepsis in terms of its epidemiology, the evolution of the definition of sepsis, pathobiology and diagnosis and management. Candidate biomarkers of interest and how current and developing point-of-care testing approaches could be used to measure such biomarkers is discussed.

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Diagnostic usefulness of sCD163, procalcitonin and neopterin for sepsis risk assessment in critically ill patients

Cited by 9 publications

References 20 publications

Pathogenic characteristics of pulmonary infection in hospitalized patients with chronic heart failure and diagnostic value of sTREM-1, sCD163, and sTWEAK

Pathogenic characteristics of pulmonary infection in hospitalized patients with chronic heart failure and diagnostic value of sTREM-1, sCD163, and sTWEAK

Prenatal ultrasound assessment of fetal lung development in normal and complicated by fetal and maternal diseases pregnancy

Biomarkers for Point-of-Care Diagnosis of Sepsis

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