Evaluation of Praziquantel Effectivenss After Decades of Prolonged Use in an Endemic Area in Egypt

Ghazy, Ramy Mohamed; Tahoun, Mohamed Mostafa; Abdo, Sarah; El-Badry, Ayman A.; Hamdy, Noha Alaa

doi:10.1007/s11686-020-00242-x

Cited by 9 publications

(10 citation statements)

References 42 publications

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“…Patients with a positive serological test should be further examined molecularly for Schistosoma-DNA, in order to avoid unnecessary treatment and the development of drug resistance to Praziquantel. Praziquantel is, to date, the only safe and effective anti-Schistosoma medicine, used for all types of human schistosomiasis as well as for control programs [4,10] . This accurate, cost effective two-step active schistosomiasis diagnostic approach requires the implementation of molecular diagnosis in endemic areas, especially those in which DNA-based techniques, particularly PCR, is already available.…”

Section: Discussionmentioning

confidence: 99%

“…This control program maintains low Schistosoma transmission and low intensity of infection, engendering the challenge of missed cases of acute schistosomiasis based on parasitological microscopy. In addition to misdiagnosis, microscopy is of limited value in diagnosis of schistosomiasis during chronic infections with a wide spectrum of chronic disease sequelae [3,9,10] .…”

Section: Introductionmentioning

confidence: 99%

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Circulating Schistosoma DNA in seropositive patients: A twostep diagnostic approach to rule-out acute and active chronic schistosomiasis in low transmission settings

Gawish¹,

Bayoumy

Raheem³

et al. 2021

Parasitologists United Journal

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Circulating Schistosoma DNA in seropositive patients: A twostep diagnostic approach to rule-out acute and active chronic schistosomiasis in low transmission settings

Gawish¹,

Bayoumy

Raheem³

et al. 2021

Parasitologists United Journal

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“…Praziquantel is active against cestodes (tapeworms). It increases the permeability of membranes for calcium ions, causes an increase in muscle activity, is accompanied by muscle contraction and spastic paralysis, and destroys the outer cover of adult forms of parasites (Tchuem Tchuenté et al, 2013;Ghazy et al, 2020). The experiments were conducted in the Laboratory of Veterinary Sanitation and Parasitology of the National Scientific Center "Institute of Experimental and Clinical Veterinary Medicine" (Kharkiv, Ukraine) and based on an animal shelter (Balakleya, Kharkiv region, Ukraine).…”

Section: Methodsmentioning

confidence: 99%

Effectiveness of a modern antiparasitic agent for deworming in domestic animals

Paliy¹,

Петров²,

Kovalenko³

et al. 2021

Ukr J Ecol

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Parasitic diseases continue to account for a significant proportion of overall morbidity in many parts of the world despite improved living conditions and increased awareness of health issues. The creation of innovative veterinary antiparasitic agents is a promising area of modern veterinary pharmacy. The pathogens Dipylidium caninum, Ancylostoma caninum, Toxocara canis, Toxocaris leonina were identified in the study of stray dogs (n=12). Eggs of Dipylidium caninum, Toxocara mystax, and Toxocaris leonina were found during cats' examination (n=15). Both mono and mixed invasions have been diagnosed in animals. We established that the floor and inventory were contaminated with exogenous forms of helminths at an extent of 100% after keeping animals in the shelter's enclosures. An innovative antiparasitic agent was used to treat animals. One tablet (0.5 g) contains the following active ingredients such as pyrantel pamoate (150±0.5 mg), praziquantel (50±0.5 mg), and auxiliary substances (lactose, microcrystalline cellulose, calcium stearate, sodium chloride, food flavoring "meat", povidone K-30 and potato starch). We estimated high antiparasitic agents' extensive efficiency (100%) at mono and mixed invasions in dogs and cats.

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“…The mean granuloma diameter, number of granulomas, types of granuloma, and state of S. mansoni eggs in all experimental groups were summarized in Table (3). There was an absence of granuloma formation in G8, treated with MFQ, and G9 treated with ½ dose GNPs and ½ dose MFQ.…”

Section: Plos Neglected Tropical Diseasesmentioning

confidence: 99%

“…Praziquantel (PZQ), the selected drug for treating all Schistosoma sp., has been verified to be inefficient to treat juvenile worms, stop parasite transmission, inhibit reinfection or moderate induced morbidity, in addition to the emergence of resistant strains with long term administration of the drug, especially in endemic areas [ 2 , 3 ]. Although the antimalarial drug, mefloquine (MFQ), exhibits potential in vitro and in vivo antischistosomal effects, there is controversy about its side effects [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Ginger (Zingiber Officinale)-derived nanoparticles in Schistosoma mansoni infected mice: Hepatoprotective and enhancer of etiological treatment

et al. 2021

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Background Nanotechnology has been manufactured from medicinal plants to develop safe, and effective antischistosmal alternatives to replace today’s therapies. The aim of the study is to evaluate the prophylactic effect of ginger-derived nanoparticles (GNPs), and the therapeutic effect of ginger aqueous extract, and GNPs on Schistosoma mansoni (S. mansoni) infected mice compared to praziquantel (PZQ), and mefloquine (MFQ). Methodology/principal findings Eighty four mice, divided into nine different groups, were sacrificed at 6th, 8th, and 10th week post-infection (PI), with assessment of parasitological, histopathological, and oxidative stress parameters, and scanning the worms by electron microscope. As a prophylactic drug, GNPs showed slight reduction in worm burden, egg density, and granuloma size and number. As a therapeutic drug, GNPs significantly reduced worm burden (59.9%), tissue egg load (64.9%), granuloma size, and number at 10th week PI, and altered adult worm tegumental architecture, added to antioxidant effect. Interestingly, combination of GNPs with PZQ or MFQ gave almost similar or sometimes better curative effects as obtained with each drug separately. The highest therapeutic effect was obtained when ½ dose GNPs combined with ½ dose MFQ which achieved 100% reduction in both the total worm burden, and ova tissue density as early as the 6th week PI, with absence of detected eggs or tissue granuloma, and preservation of liver architecture. Conclusions/significance GNPs have a schistosomicidal, antioxidant, and hepatoprotective role. GNPs have a strong synergistic effect when combined with etiological treatments (PZQ or MFQ), and significantly reduced therapeutic doses by 50%, which may mitigate side effects and resistance to etiological drugs, a hypothesis requiring further research. We recommend extending this study to humans.

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Evaluation of Praziquantel Effectivenss After Decades of Prolonged Use in an Endemic Area in Egypt

Cited by 9 publications

References 42 publications

Circulating Schistosoma DNA in seropositive patients: A twostep diagnostic approach to rule-out acute and active chronic schistosomiasis in low transmission settings

Circulating Schistosoma DNA in seropositive patients: A twostep diagnostic approach to rule-out acute and active chronic schistosomiasis in low transmission settings

Effectiveness of a modern antiparasitic agent for deworming in domestic animals

Ginger (Zingiber Officinale)-derived nanoparticles in Schistosoma mansoni infected mice: Hepatoprotective and enhancer of etiological treatment

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