Evaluation of polyphenylene ether ether sulfone/nanohydroxyapatite nanofiber composite as a biomaterial for hard tissue replacement

Abstract

The present work is aimed at investigating the mechanical and in vitro biological properties of polyphenylene ether ether sulfone (PPEES)/nanohydroxyapatite (nHA) composite fibers. Electrospinning was used to prepare nanofiber composite mats of PPEES/nHA with different weight percentages of the inorganic filler, nHA. The fabricated composites were characterized using Fourier transform infrared spectroscopy (FTIR)-attenuated total reflectance spectroscopy (ATR) and scanning electron microscopy (SEM)-energy dispersive X-ray spectroscopy (EDX) techniques. The mechanical properties of the composite were studied with a tensile tester. The FTIR-ATR spectrum depicted the functional group as well as the interaction between the PPEES and nHA composite materials; in addition, the elemental groups were identified with EDX analysis. The morphology of the nanofiber composite was studied by SEM. Tensile strength analysis of the PPEES/nHA composite revealed the elastic nature of the nanofiber composite reinforced with nHA and suggested significant mechanical strength of the composite. The biomineralization studies performed using simulated body fluid with increased incubation time showed enhanced mineralization, which showed that the composites possessed high bioactivity property. Cell viability of the nanofiber composite, studied with osteoblast (MG-63) cells, was observed to be higher in the composites containing higher concentrations of nHA.Electronic supplementary materialThe online version of this article (doi:10.1186/2194-0517-2-2) contains supplementary material, which is available to authorized users.

Effect of TiO2nanoparticles on the performance of polyphenylsulfone biomaterial for orthopaedic implants

“…The increments found in this work are considerably larger than those attained upon addition of other inorganic nanollers like POSS to PPSU 13 or nanohydroxyapatite (HA) 34 or organoclay 35 to PES. Only the incorporation of small amounts (#1.0 wt%) of GO to PES 7 resulted in higher stiffness and strength improvements, which is reasonable considering the exceptional modulus of this carbon nanoller ($1 TPa).…”

Advances in Electrospun Hybrid Nanofibers for Biomedical Applications

“…The biocide effect was most pronounced on composites based on graphene oxide, less on graphene composites, and not present on gelatin and chitosan fibers containing only hydroxyapatite. Nanofiber mats electrospun from polyethersulphone containing hydroxyapatite nanoparticles were evaluated acellularly, in vitro on osteoblast (MG-63) cells and in vivo on rabbits’ tibia [ 192 ]. The authors found that the presence of nanoparticles increased bioactivity in simulated body fluid.…”

Nanofiltration Composite Membranes Based on KIT-6 and Functionalized KIT-6 Nanoparticles in a Polymeric Matrix with Enhanced Performances

“…Our previous studies showed that PPEES can be successfully applied to obtain ultrafiltration membranes for concentration of the herbal extract [ 29 ]. PPEES received in the last time more attention due to the specific properties, such as less hydrophobicity, good solubility, good electronic properties, high thermal resistance and a good chemical stability [ 30 , 31 ]. An interesting application was as cross-linkers, to induce the polymer network with interpenetrating structure, and at the same time, as a spreader to homogeneously disperse SiO 2 nanoparticles in nanocomposite membranes [ 32 ].…”