Evaluation of Platelet Transfusion Triggers in Hematopoietic Stem Cell Transplant Patients

Oka, Shiro; Haraike, Sumiyo; Kawano, Tomoaki; Yamamoto, Masaaki; Matsuoka, Naruto; Azuma, Yukina; Kitabayashi, Aya; Shirai, Nao; Matsumoto, Ayami; Taniguchi, Akiko; Nougawa, Masaharu

doi:10.3925/jjtc.63.599

Cited by 3 publications

(2 citation statements)

References 16 publications

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“…Hematopoietic stem cell transplantation cases are stratified into low, moderate, and high-risk patients according to factors related to PC transfusion, and it is reported that appropriate blood transfusion is possible by performing preventive and therapeutic PC transfusion according to risk is doing 21) . A study on the safety of exercise intervention in patients with acute leukemia or advanced lymphoma reported that none of the patients with a Plt value of less than 10,000/µL experienced bleeding 5) .…”

Section: Discussionmentioning

confidence: 99%

Rehabilitation intervention safety in patients with malignant lymphoma with low blood cell counts

2023

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We established criteria for patients with malignant lymphoma with low blood counts, who did not meet the criteria to discontinue rehabilitation or the blood transfusion criteria even though they were borderline for discontinuing rehabilitation. We investigated physical symptoms, activities of daily living, and adverse events in patients who were permitted to undergo rehabilitation intervention using the new criteria. [Participants and Methods] Forty-two patients met the criteria to discontinue rehabilitation based on blood data, and the newcriteria group included 153 patients who received permission for rehabilitation from a hematologist despite not meeting the criteria to discontinue rehabilitation. The survey items were Barthel index at the time of admission and discharge and the length of hospital stay. A two-group comparison was performed, and the occurrence of adverse events associated with exercise intervention were investigated. [Results] The length of hospital stay was shortened in the new-criteria group, and the rehabilitation intervention rate improved. [Conclusion] For patients with malignant lymphoma with low blood cell counts, continuing rehabilitation intervention with physician permission may prevent a decline in activities of daily living as well as maintain and improve motor function.

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Section: Discussionmentioning

confidence: 99%

Rehabilitation intervention safety in patients with malignant lymphoma with low blood cell counts

2023

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“…Oka et al 20) reported that in remission induction therapy for acute leukemia, reducing the PC transfusion trigger level from 20,000/µL to 10,000/µL decreased the use of PC transfusions without increasing the risk of hemorrhage. Further, they stratified patients undergoing hematopoietic stem cell transplantation into low-, moderate-, or high-risk patients in terms of PC-transfusion-related risk factors and administering prophylactic or therapeutic PC transfusions in accordance with the riskenabled transfusions 21) . In a narrative review, Morishita et al suggested that patients with a Plt count of 10,000-20,000/µL should undergo exercise therapy comprising non-resistance exercises in the seated or standing postures, protective stretching exercises, and walking 22) .…”

Section: Discussionmentioning

confidence: 99%

Safety of rehabilitation interventions for patients with hematologic diseases associated with low blood counts—verification focusing on blood cancer

2021

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This study aimed to establish unique criteria for hematologic patients with low blood counts in the borderline region of or below the threshold for discontinuing cancer rehabilitation without meeting the criteria for blood transfusion, and to investigate the physical symptoms and activities of daily living. [Participants and Methods] Among the 251 participants, 128 had blood test results below the discontinuation criteria. They were permitted to engage in rehabilitation interventions by a hematologist based on the new criteria. The remaining 123 patients were classified under the discontinuation group. The Barthel Index scores during admission and discharge were compared between the two groups, in terms of chemotherapy, physical symptoms of nausea, petechial hemorrhage, pyrexia, and diarrhea. [Results] There was no significant difference between the two groups in terms of the Barthel Index score during admission or discharge. Pyrexia occurred more frequently in patients managed under the new criteria. [Conclusion] Patients with low blood counts that fall between the criteria for discontinuing rehabilitation and receiving blood transfusions can continue undergoing rehabilitation interventions with the permission of their doctors, provided that measures are taken to manage adverse events. This strategy prevents activities of daily living reduction.

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Incidence and management of non-immune platelet transfusion refractoriness: a narrative review

Hagino¹,

Sato²,

Tsuno³

et al. 2021

Ann Blood

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Evaluation of Platelet Transfusion Triggers in Hematopoietic Stem Cell Transplant Patients

Cited by 3 publications

References 16 publications

Rehabilitation intervention safety in patients with malignant lymphoma with low blood cell counts

Rehabilitation intervention safety in patients with malignant lymphoma with low blood cell counts

Safety of rehabilitation interventions for patients with hematologic diseases associated with low blood counts—verification focusing on blood cancer

Incidence and management of non-immune platelet transfusion refractoriness: a narrative review

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