Evaluation of platelet indices and mean platelet volume to platelet count ratio in experimentally varicocele‐induced adolescent and adult rats

Abstract

The present study investigated the sperm quality parameters and platelet indices in adolescent and adult varicocele rats. Twenty male Wistar rats were distributed into four groups (n = 5): I—sham adolescent group, II—sham adult group, III—varicocele adolescent group, and IV—varicocele adult group. Rats were sacrificed on the 61st day of the experiment. Sperm count (×106 ml−1), sperm motility and viability (%) were significantly (p < 0.05) different between varicocele and sham groups in adolescent and adult rats. Varicocele adults had significant (p < 0.05) lower platelet count (PLT) than sham adolescents and adults. The mean platelet volume (MPV), the MPV/PLT ratio, plateletcrit (PCT) and platelet distribution width (PDW) differ significantly (p < 0.05) between varicocele and sham groups of adolescent and adult rats. It is the first time the ratio MPV/PLT was evaluated in association with other platelet indices in adolescent and adult varicocele rats. Based on the results, it would appear these indicators can become a promising tool in varicocele diagnosis.

Duration of the diabetic state altered platelet indices from baseline values in a streptozotocin‐induced rat model for type 1 diabetes mellitus

“…Compared with the nondiabetic control rats, the female diabetic rats of the 7‐day diabetic group in this study showed a moderate increase in MPV to PLT, but not as marked as the 28‐day diabetic female rats. Several studies have shown that a low PLT may suggest increased platelet activation in humans with cardiovascular disease by increasing glycoprotein VI and inflammatory marker levels 26–28 . The MPV‐to‐PLT ratio, along with other platelet indices, were used for the first time in diabetic male and female rats.…”

“…Several studies have shown that a low PLT may suggest increased platelet activation in humans with cardiovascular disease by increasing glycoprotein VI and inflammatory marker levels. [26][27][28] The MPV-to-PLT ratio, along with other platelet indices, were used for the first time in diabetic male and female rats. The correlation observed in this study between MPV and the MPV-to-PLT ratio with glucose was positively strong and moderate in female and male rats, respectively.…”