Evaluation of pimobendan effect on sublingual microcirculation in an experimental pharmacology induced hypotension porcine model

Magnin, Mathieu; Bonnet-Garin, Jeanne-Marie; Laurenza, Chiara; Didier, Caroline; Gavet, Morgane; Nectoux, Alexandra; Allaouchiche, Bernard; Junot, Stéphane

doi:10.1016/j.rvsc.2022.03.021

Cited by 7 publications

(5 citation statements)

References 35 publications

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“…However, all the currently used software packages have limitations [ 36 ]. Of note, the AVA4.3C has been used in studies published in journals specializing in microcirculation and in other peer-reviewed journals [ 37 , 38 , 39 , 40 , 49 , 50 , 51 ], while at least three published studies report that the AVA4.3C is a validated automatic algorithm-software [ 37 , 38 , 39 ]. Furthermore, we analyzed several videos at each time, used continuous measurements, which allowed a better comparison over time, and followed the recommended methodology for sublingual microcirculation videos [ 36 ].…”

Section: Discussionmentioning

confidence: 99%

Association of Preoperative Basal Inflammatory State, Measured by Plasma suPAR Levels, with Intraoperative Sublingual Microvascular Perfusion in Patients Undergoing Major Non-Cardiac Surgery

Chalkias

Papagiannakis

Saugel

et al. 2022

JCM

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It remains unknown whether chronic systemic inflammation is associated with impaired microvascular perfusion during surgery. We evaluated the association between the preoperative basal inflammatory state, measured by plasma soluble urokinase-type plasminogen activator receptor (suPAR) levels, and intraoperative sublingual microcirculatory variables in patients undergoing major non-cardiac surgery. Plasma suPAR levels were determined in 100 non-cardiac surgery patients using the suPARnostic® quick triage lateral flow assay. We assessed sublingual microcirculation before surgical incision and every 30 min during surgery using Sidestream Darkfield (SDF+) imaging and determined the De Backer score, the Consensus Proportion of Perfused Vessels (Consensus PPV), and the Consensus PPV (small). Elevated suPAR levels were associated with lower intraoperative De Backer score, Consensus PPV, and Consensus PPV (small). For each ng mL−1 increase in suPAR, De Backer score, Consensus PPV, and Consensus PPV (small) decreased by 0.7 mm−1, 2.5%, and 2.8%, respectively, compared to baseline. In contrast, CRP was not significantly correlated with De Backer score (r = −0.034, p = 0.36), Consensus PPV (r = −0.014, p = 0.72) or Consensus PPV Small (r = −0.037, p = 0.32). Postoperative De Backer score did not change significantly from baseline (5.95 ± 3.21 vs. 5.89 ± 3.36, p = 0.404), while postoperative Consensus PPV (83.49 ± 11.5 vs. 81.15 ± 11.8, p < 0.001) and Consensus PPV (small) (80.87 ± 13.4 vs. 78.72 ± 13, p < 0.001) decreased significantly from baseline. In conclusion, elevated preoperative suPAR levels were associated with intraoperative impairment of sublingual microvascular perfusion in patients undergoing elective major non-cardiac surgery.

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Section: Discussionmentioning

confidence: 99%

Association of Preoperative Basal Inflammatory State, Measured by Plasma suPAR Levels, with Intraoperative Sublingual Microvascular Perfusion in Patients Undergoing Major Non-Cardiac Surgery

Chalkias

Papagiannakis

Saugel

et al. 2022

JCM

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“…Pimobendan is licensed for veterinary use and indicated for the treatment of heart failure in dogs. In Japan, pimobendan is used with human patients [1]. Oral pimobendan is used for treating congestive heart failure in dogs and cats [2].…”

Section: Introductionmentioning

confidence: 99%

“…The cardiotonic drug pimobendan (C 19 H 18 N 4 O 2 ), shown in Figure 1a, is a calcium sensitizer and selective inhibitor of phosphodiesterase III. Cardiotonic therapy was demonstrated to increase life span in dogs [1]. Pimobendan is licensed for veterinary use and indicated for the treatment of heart failure in dogs.…”

Section: Introductionmentioning

confidence: 99%

Gold–graphitic carbon nitride composite electrode for pimobendan detection

Luk,

Chang,

et al. 2023

J Chinese Chemical Soc

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IntroductionHeart failure can lead to death and hospitalization, especially among older adults, and pimobendan is used with human patients. We investigated the electrochemical behavior of Au/g‐C3N4 electrochemical sensors to detect the concentration of pimobendan.ExperimentalCharacterization of the materials was conducted using XRD, TEM, SEM, EDS and FTIR. Cyclic voltammetry (CV) was used to measure the concentration and redox properties of pimobendan.Result and DiscussionsAt a voltage of 0.05 V, a reduction peak appeared, indicating an association between pimobendan concentration (ranging from 0 to 55 μM) and reductive current. At low concentrations of pimobendan concentration from 0.0 to 1.3 μM, the linearity R2 = 0.9149 with a detection limit of 0.29 μM. Dopamine, epinephrine, and uric acid did not interfere with the detection of pimobendan.ConclusionsA composite sensing electrode consisting of 3% Au/g‐C3N4 was fabricated for the detection of pimobendan. A potential pimobendan sensing mechanism on 3% Au/g‐C3N4 was proposed on the basis of these findings.

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“…Heart failure is an increasing public health problem, mainly in the elderly, and is one of the important sources of death and hospitalization in elderly patients. The cardiotonic drug pimobendan (C19H18N4O2) in Figure 1(a) is a calcium sensitizer and selective inhibitor of phosphodiesterase III, studies have shown that as a canine cardiotonic therapy can increase lifespan [1]. Pimobendan is a drug licensed for veterinary use indicated for the treatment of heart failure in dogs and it is also used in Japan in human patients [1].…”

Section: Introductionmentioning

confidence: 99%

“…The cardiotonic drug pimobendan (C19H18N4O2) in Figure 1(a) is a calcium sensitizer and selective inhibitor of phosphodiesterase III, studies have shown that as a canine cardiotonic therapy can increase lifespan [1]. Pimobendan is a drug licensed for veterinary use indicated for the treatment of heart failure in dogs and it is also used in Japan in human patients [1]. Oral pimobendan is used for treating congestive heart failure (CHF) in dogs and cats [2].…”

Section: Introductionmentioning

confidence: 99%

Fabrication of Gold-Graphitic Carbon Nitride Composite Electrode for the Detection of Pimobendan

Luk¹,

Chang²,

Wu³

2023

Preprint

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In this study, the preparation of the composite 3% Au/graphite-C3N4 (3% Au/g-C3N4) sensing material was prepared by doping 3% Au onto the surface of graphitic carbonitride (C3N4) for detection pimobendan. By the way of sensing materials characterization, the X-ray diffraction analysis (XRD) and transmission electron Microscope (TEM) were performed. The cyclic voltammetry (CV) was used to measure the concentration and redox properties of pimobendan. It can be seen that when the voltage value is 0.05 V, and a reduction peak was appeared and the pimobendan concentration (0 to 55 μM) has a relationship with the reduction current value. At low concentrations of pimobendan concentration from 0.0 to 0.8 μM, the linearity R2 = 0.9642 with a detection limit of 0.28 μM. A possible pimobendan sensing mechanism on 3% Au/g-C3N4 was proposed.

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Evaluation of pimobendan effect on sublingual microcirculation in an experimental pharmacology induced hypotension porcine model

Cited by 7 publications

References 35 publications

Association of Preoperative Basal Inflammatory State, Measured by Plasma suPAR Levels, with Intraoperative Sublingual Microvascular Perfusion in Patients Undergoing Major Non-Cardiac Surgery

Association of Preoperative Basal Inflammatory State, Measured by Plasma suPAR Levels, with Intraoperative Sublingual Microvascular Perfusion in Patients Undergoing Major Non-Cardiac Surgery

Gold–graphitic carbon nitride composite electrode for pimobendan detection

Fabrication of Gold-Graphitic Carbon Nitride Composite Electrode for the Detection of Pimobendan

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