Evaluation of Phytocompounds and Chemical Elements Present In Selected Species of Seaweeds, to Sustain Future Quantitative Analysis for Bioactive Compounds

Dias, Valera; Bandeira, Salomão; Chaúque, Eutilério F.C.; Lipassula, Maurício; Mussagy, Aidate

doi:10.22270/jddt.v10i5.4422

Cited by 4 publications

(8 citation statements)

References 23 publications

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“…Marine macroalgae produce both primary metabolites, including proteins, amino acids, polysaccharides, fatty acids, etc., and secondary metabolites, such as phenolic compounds, pigments, sterols, vitamins, and other bioactive components [ 48 , 49 , 50 , 51 , 52 , 53 , 54 ]. Moreover, various types of biological activities expressed by different phycocompounds, such as blood coagulation system, antilipidemic activity, immunomodulating effect, antiviral activity, anticancer activity, antimicrobial activity, antioxidant activity, and other significant activities [ 55 ].…”

Section: Introductionmentioning

confidence: 99%

Seaweed-Based Molecules and Their Potential Biological Activities: An Eco-Sustainable Cosmetics

Kalasariya¹,

Yadav²,

Yadav³

et al. 2021

Molecules

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Amongst the countless marine organisms, seaweeds are considered as one of the richest sources of biologically active ingredients having powerful biological activities. Seaweeds or marine macroalgae are macroscopic multicellular eukaryotic photosynthetic organisms and have the potential to produce a large number of valuable compounds, such as proteins, carbohydrates, fatty acids, amino acids, phenolic compounds, pigments, etc. Since it is a prominent source of bioactive constituents, it finds diversified industrial applications viz food and dairy, pharmaceuticals, medicinal, cosmeceutical, nutraceutical, etc. Moreover, seaweed-based cosmetic products are risen up in their demands by the consumers, as they see them as a promising alternative to synthetic cosmetics. Normally it contains purified biologically active compounds or extracts with several compounds. Several seaweed ingredients that are useful in cosmeceuticals are known to be effective alternatives with significant benefits. Many seaweeds’ species demonstrated skin beneficial activities, such as antioxidant, anti-melanogenesis, antiaging, photoprotection, anti-wrinkle, moisturizer, antioxidant, anti-inflammatory, anticancer and antioxidant properties, as well as certain antimicrobial activities, such as antibacterial, antifungal and antiviral activities. This review presents applications of bioactive molecules derived from marine algae as a potential substitute for its current applications in the cosmetic industry. The biological activities of carbohydrates, proteins, phenolic compounds and pigments are discussed as safe sources of ingredients for the consumer and cosmetic industry.

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Section: Introductionmentioning

confidence: 99%

Seaweed-Based Molecules and Their Potential Biological Activities: An Eco-Sustainable Cosmetics

Kalasariya¹,

Yadav²,

Yadav³

et al. 2021

Molecules

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“…Phytochemical profiling of algal samples by advanced analytical techniques revealed the presence and relative amounts of different phytochemicals, many with important medicinal properties (e.g., antimicrobial, anti-inflammatory, antioxidant) [8,24]. Preliminary qualitative phytochemical analysis was carried out to identify the secondary metabolites such as alkaloids, flavonoids, terpenoids, steroids, tannins, phenols, quinones, glycosides, flavanones, flavonols, steroids, and saponins present in the alcoholic/aqueous extracts of marine algae [68][69][70]. The variation in the antimicrobial and antioxidant activities were due to various parameters at the time the algal samples were collected.…”

Section: Qualitative and Quantitative Aspects Of Algal-derived Biocompoundsmentioning

confidence: 99%

“…Other phytochemical screenings of different algal extracts were assessed using standard methods. An FeCl 3 test for tannins in methanolic extracts was assessed for brown seaweeds (i.e., Dictyota dichotoma and Sargassum wightii), green seaweeds (i.e., Cladophora glomerata, Ulva lactuca, and Ulva reticulata), and red seaweeds (i.e., Jania rubens, Corallina mediterranea, and Pterocladia capillacea), and the results revealed that tannins are common phytocompounds in seaweeds [68,70]. These algal species can be used as a drug for gonorrhea and as healing agents, and seem to exert anti-viral, anti-bacterial, and anti-ulcer activities [50,65].…”

Section: Qualitative and Quantitative Aspects Of Algal-derived Biocompoundsmentioning

confidence: 99%

“…The variation in the antimicrobial and antioxidant activities were due to various parameters at the time the algal samples were collected. These parameters include the (i) presence and relative number of secondary metabolites (of phenolic or free hydroxyl nature) in algae, (ii) method of extraction of the biocompounds and the solvent used in this extraction, (iv) maturity stage of algae, and (v) environmental conditions (e.g., habitats, seasons) [ 70 , 71 , 72 ].…”

Section: Qualitative and Quantitative Aspects Of Algal-derived Biocompoundsmentioning

confidence: 99%

“…Qualitative colorimetric methods were used to evaluate the phytocompounds, and among the different procedures, methanolic extracts were found to have the highest reducing power in comparison with other solvents, such as ethanol, chloroform, and acetone [ 70 , 73 ]. However, results remain controversial among different studies and seem to be species-specific [ 70 ]. The maximum content of phenolic compounds, such as tannins and flavonoids, has been found in red and brown seaweeds [ 68 ].…”

Section: Qualitative and Quantitative Aspects Of Algal-derived Biocompoundsmentioning

confidence: 99%

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Marine Algae-Derived Bioactive Compounds: A New Wave of Nanodrugs?

Menaa

Wijesinghe²,

Thiripuranathar³

et al. 2021

Marine Drugs

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Marine algae are rich in bioactive nutraceuticals (e.g., carbohydrates, proteins, minerals, fatty acids, antioxidants, and pigments). Biotic (e.g., plants, microorganisms) and abiotic factors (e.g., temperature, pH, salinity, light intensity) contribute to the production of primary and secondary metabolites by algae. Easy, profitable, and sustainable recovery methods include novel solid-liquid and liquid-liquid extraction techniques (e.g., supercritical, high pressure, microwave, ultrasound, enzymatic). The spectacular findings of algal-mediated synthesis of nanotheranostics has attracted further interest because of the availability of microalgae-based natural bioactive therapeutic compounds and the cost-effective commercialization of stable microalgal drugs. Algal extracts can serve as stabilizing/capping and reducing agents for the synthesis of thermodynamically stable nanoparticles (NPs). Different types of nanotherapeutics have been synthesized using physical, chemical, and biological methods. Marine algae are a fascinating source of lead theranostics compounds, and the development of nanotheranostics has been linked to enhanced drug efficacy and safety. Indeed, algae are remarkable nanobiofactories, and their pragmatic properties reside in their (i) ease of handling; (ii) capacity to absorb/accumulate inorganic metallic ions; (iii) cost-effectiveness; and (iv) capacity of eco-friendly, rapid, and healthier synthesis of NPs. Preclinical and clinical trials shall enable to really define effective algal-based nanotherapies. This review aims to provide an overview of the main algal compounds that are nutraceuticals and that can be extracted and purified for nanotheranostic purposes.

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Enhancement of cytotoxic and antioxidant activities of Digenea simplex chloroform extract using the nanosuspension technique

El-Rafie

Hasan

Zahran

2022

Bioprocess Biosyst Eng

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Digenea simplex (D. simplex), an Egyptian marine red macroalga, contains a diverse group of phytochemicals with unique bioactivities. At the same time, the synthesis of nanosuspension (NS) has received increasing interest to optimize the technological aspects of drugs. Thence, the main objective of this work was to use the chloroform extract (ChlE) of D. simplex to prepare its nanosuspension (ChlE-NS) formulation to increase its aqueous solubility, thereby improving its bioactivity. By using FTIR, GC/MS analysis, and phytochemical screening assays, the chemical profiling of ChlE was assessed. NS was prepared by the antisolvent precipitation technique using 1.5% w/v polyvinyl alcohol (PVA). A light microscope, FTIR, particle size distribution, polydispersity index (PDI), and zeta potential (ZP) measurements was used to characterize the prepared NS. Four cancer cell lines were used in the MTT experiment to investigate the anticancer potential of ChlE and ChlE-NS. An apoptotic mechanism was established using acridine orange/ethidium bromide (AO/EB) dual staining, DNA fragmentation, and increased caspase activity. ChlE and ChlE-NS were also evaluated as antioxidants using DPPH and ABTS free radical assays. The results showed that, when compared to ChlE, ChlE-NS had greater cytotoxic activity against the four cancer cell lines. However, results of antioxidant activity showed that ChlE-NS had an IC50 of 36.86 ± 0.09 and 63.5 ± 0.47%, while ChlE had values of 39.90 ± 0.08 and 86.5 ± 0.8% in DPPH and ABTS assays, respectively. Based on the results of this research, D. simplex ChlE-NS may be an effective strategy for enhancing ChlE's cytotoxic and antioxidant activities. Graphical abstract

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Evaluation of Phytocompounds and Chemical Elements Present In Selected Species of Seaweeds, to Sustain Future Quantitative Analysis for Bioactive Compounds

Cited by 4 publications

References 23 publications

Seaweed-Based Molecules and Their Potential Biological Activities: An Eco-Sustainable Cosmetics

Seaweed-Based Molecules and Their Potential Biological Activities: An Eco-Sustainable Cosmetics

Marine Algae-Derived Bioactive Compounds: A New Wave of Nanodrugs?

Enhancement of cytotoxic and antioxidant activities of Digenea simplex chloroform extract using the nanosuspension technique

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