Evaluation of phytochemical and pharmacological activities of Bacopa monnieri (L.)

Abstract

<p class="abstract"><strong>Background:</strong> <em>Bacopa monnieri</em> (L.) locally called Brahmi of Scrophulariaceae family has a long history for numerous therapeutic purposes like memory enhancing, antianxiety and antiepileptic agent. The aim of this study was to investigate phytochemical screening, antibacterial, cytotoxic, analgesic and neuropharmacological activities of <em>B. monnieri</em>.</p><p class="abstract"><strong>Methods:</strong> The antibacterial activity was performed by disc diffusion method. Brine shrimp lethality bioassay was carried out to determine cytotoxic potential. Acetic acid induced writhing method was employed for the assessment of analgesic activity of <em>B. monnieri</em> extracts. The neuropharmacological activity was determined by hole cross, open field and thiopental sodium induced sleeping time test using Swiss Albino mice as experimental animal.</p><p class="abstract"><strong>Results:</strong> Phytochemical screening revealed that <em>n-</em>hexane, dichloromethame and methanolic extracts contained reducing sugar, alkaloids, flavonoids, steroids and saponins. The sample showed comparable antimicrobial and cytotoxic activity. In analgesic activity test, methanol soluble extract showed highest activity compared to standard drug, Diclofenac sodium. The neuropharmacological activity of three extracts showed moderate activity as compared with standard drug, Diazepam and Thiopental sodium.</p><p class="abstract"><strong>Conclusions:</strong> Our exploration suggests that <em>B. monnieri</em> contains bioactive compounds and it should be studied further for isolation and purification of such novel compounds.</p><p class="abstract"> </p>

Transcriptome-wide miRNA identification of Bacopa monnieri: a cross-kingdom approach

“…13 This plant is well known for its improvement of brain function along with memory enhancement, antioxidant, antitoxic, hepatoprotactive, anti-hypertensive, anti-diarrheal, analgesic, antiulcer, antibacterial, antifungal, anticancer, antioxidant, anti-inflammatory, antidepressant and antiepileptic activities. 14,15 Since first discovered Caenorhabditis elegans miRNA, a significant number of microRNAs have been discovered but no miRNAs have been reported in the miRBase repository for the B. monnieri species. Therefore, in the present study, a B. monnieri transcriptome from the Sequence Read Archive database, assembled by paired-end short reads of the plant shoot and root was used for computational prediction of miRNAs and their human targets.…”

Use of an exotic host plant reduces viral burden in a native insect herbivore

“…However, sequestration of high concentrations of IGs has also been associated with suppression of lepidopteran immune responses (Smilanich et al, 2009;Lampert & Bowers, 2015). In contrast, Bacopa contains no IGs, but contains a variety of other secondary compounds (Basak et al, 2016), none of which are known to be sequestered.…”

Autistic Effects of Nootropic Drug Brahmi against Propionic Acid-induced Behavior and Memory Impairment in Rat Model

“…Phytochemical Test [15,16,17] Preliminary phytochemical screening of Hydro alcoholic extract of Bacopa monnieri were conducted and found in HAEBM absence of terpenoids, quinones and glycosides were confirmed.…”