Evaluation of pharmacological activities and assessment of intraocular penetration of an ayurvedic polyherbal eye drop (Itone™) in experimental models

Velpandian, Thirumurthy; Gupta, Pankaj; Ravi, A.; Sharma, Hunny; Biswas, Nihar Ranjan

doi:10.1186/1472-6882-13-1

Cited by 217 publications

(162 citation statements)

References 28 publications

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“…The different level of activities of the two fungi isolated from the same species may be attributed to the different chemical composition of each extract. This is in agreement with the observations of Gul et al (2013). …”

Section: Discussionsupporting

confidence: 94%

Antiangiogenic, wound healing and antioxidant activity ofCladosporium cladosporioides(Endophytic Fungus) isolated from seaweed (Sargassum wightii)

et al. 2016

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Endophytic fungi from marine seaweeds are the less studied group of organisms with vast medical applications. The aim of the present study was to evaluate antioxidant, antiangiogenic as well as wound healing potential of the endophytic fungus isolated from the seaweed Sargassum wightii. The morphological characters and the rDNA internal transcribed spacer sequence analysis (BLAST search in Gen Bank database) was used for the identification of endophytic fungus. The antioxidant potential of the ethyl acetate extract of endophytic fungus was assessed by, 1,1-diphenyl-2-picryl-hydrazyl radical scavenging method. The fungal extract was also analysed for reducing power, total phenolic and flavonoid content. Antiangiogenic activity of the fungal extract was studied in vitro by inhibition of wound healing scratch assay and in vivo by Chick chorioallantoic membrane assay. The endophytic fungus was identified as Cladosporium cladosporioides (Gen Bank ID – KT384175). The ethyl acetate extract of C. cladosporioides showed a significant antioxidant and angiosuppressive activity. The ESI-LC-MS analysis of the extract revealed the presence of wide range of secondary metabolites. Results suggest that C. cladosporioides extract could be exploited as a potential source for angiogenic modulators.

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Section: Discussionsupporting

confidence: 94%

Antiangiogenic, wound healing and antioxidant activity ofCladosporium cladosporioides(Endophytic Fungus) isolated from seaweed (Sargassum wightii)

et al. 2016

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“…As shown in Figure 1, accumulated data indicate that casticin was isolated from many plant species such as, namely Vitex agnus castus (Choudhary et al, 2009;Mesaik et al, 2009;Webster et al, 2011;Righeschi et al, 2012;Hogner et al, 2013), Daphne genkwa (Xie et al, 2011), Achillea millefolium (Haidara et al, 2006;Csupor-Loffler et al, 2009), Ficus microcarpa , Vitex rotundifolia (Ono et al, 2002;Hu et al, 2007b;Shen et al, 2009;Ye et al, 2010;Koh et al, 2011), Fructus viticis (Hu et al, 2007b;Guan et al, 2010;Chen et al, 2011b;Yang et al, 2011;Zeng et al, 2012;Zhou et al, 2013a), Vitex negundo (Diaz et al, 2003;Kunwar et al, 2010;Velpandian et al, 2013), Crataegus pinnatifida (Kao et al, 2005), Pavetta crassipes (Mali and Dhake, 2011), Nelsonia canescens, Butea frondosa Koen , Dalbergia odorifera (Mali and Dhake, 2011), Bryonia laciniosa (Aggarwal et al, 2011), Citrus unshu (Mali and Dhake, 2011;Nagoor et al, 2011), Centipeda minima (Mali and Dhake, 2011), Clausena excavate (Manosroi et al, 2005), Croton betulaster (de Sampaio e Spohr et al, 2010;Freitas et al, 2011), Dimorphandra mollis (Freitas et al, 2011), Artemisia abrotanum L. (Hernandez et al, 1999), Artemisia annua L …”

Section: Natural Sources Of Casticinmentioning

confidence: 99%

“…It inhibited eosinophil migration and activity of chemokines and adhesion of molecules involved in the inflammatory process of asthma by suppressing the NF-κB pathway (Koh et al, 2011). Casticin's biological effects have been reported in wide spectrum of indications (Table 1), including inflammation (Lin et al, 2007b;Koh et al, 2011;Lee et al, 2012), asthma (Koh et al, 2011), tumor (Ono et al, 2002;Hu et al, 2007b;Shen et al, 2009;Ye et al, 2010;Koh et al, 2011), pre-menstrual syndrome (Hu et al, 2007b;Webster et al, 2011), immunomodulation (You et al, 1998), headache (Choudhary et al, 2009;Mesaik et al, 2009;Webster et al, 2011;Righeschi et al, 2012;Hogner et al, 2013), rheumatoid arthritis (You et al, 1998), conjunctivitis (Remberg et al, 2004), trachoma, gonorrhoea, and toothache (Diaz et al, 2003;Kunwar et al, 2010;Velpandian et al, 2013).…”

Section: Biological Activity Of Casticinmentioning

confidence: 99%

“…Casticin (3', 5-dihydroxy-3, 4', 6, 7-tetramethoxyflavone) is one of the bioactive flavonoids obtained from polyphenol plants, which are composed of a wide variety of molecules that are classified into several categories, according to their chemical type, such as phenolic acids, flavonoids, stilbenes, and lignans (Siasos et al, 2013 ). Casticin is a main active compound in roots, aerial parts, seed, wood, stems, leaves and fruits of variety of plants ( Figure 1 and Table 1), has been reported to be responsible for a wide spectrum of biological and pharmacological activities including immunomodulatory (Mesaik et al, 2009;Ling et al, 2012), anti-hyperprolactinemia (Hu et al, 2007b;Ye et al, 2010), anti-tumor (Haidara et al, 2006;Shen et al, 2009;Ling et al, 2012;Zeng et al, 2012), neuroprotetective (Ling et al, 2012), anti-inflammatory (Lin et al, 2007b;Choudhary et al, 2009;Velpandian et al, 2013) and analgesic activities (Lee et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

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Molecular Mechanisms of Casticin Action: an Update on its Antitumor Functions

Rasul

Zhao²,

Li³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Casticin (3', 5-dihydroxy-3, 4', 6, 7-tetramethoxyflavone) is an active compound isolated from roots, stems, leaves, fruits and seeds of a variety of plants. It is well known for its pharmacological properties and has been utilized as an anti-hyperprolactinemia, anti-tumor, anti-inflammatory, neuroprotetective, analgesic and immunomodulatory agent. Recently, the anticancer activity of casticin has been extensively investigated. The resulkts showed that it exerts protective potential by targeting apoptosis, considered important for cancer therapies. In this article, our aim was to review the pharmacological and therapeutic applications of casticin with specific emphasis on its anticancer functions and related molecular mechanisms. Chemotherapeutic effects are dependent on multiple molecular pathways, which may provide a new perspective of casticin as a candidate anti-neoplastic drug. This review suggests that additional studies and preclinical trials are required to determine specific intracellular sites of action and derivative targets in order to fully understand the mechanisms of its antitumor activity and validate this compound as a medicinal agent for the prevention and treatment of various cancers.

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“…In fact, when this homeostasis is disrupted and there are more reactive species than antioxidants several diseases can develop. 15 Recent studies indicate that an increased oxidative stress is related to the pathogenesis of COPD, 1,[16][17][18] and contribute this to the fact that COPD patients produce more H 2 O 2 compared to "healthy". 19 Another study hypothesized that loss of asthmatic SOD activity is due to greater susceptibility to oxidative inactivation.…”

Section: Discussionmentioning

confidence: 99%

Role of Apo E and superoxide dismutase in patients with obstructive lung diseases

Almzaiel

Al-Ameri

Tariq

2017

J. contemp. med. sci.

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Objective Obstructive lung diseases (OLD) are chronic inflammatory disorders of the respiratory tract including asthma and chronic obstructive pulmonary disease (COPD). Apo lipoprotein E (Apo E), is a multifunctional protein as it intervenes the binding of lipoproteins or lipid complexes to specific cell-surface receptors. Experimental studies referred to the function of Apo E as an endogenous negative regulator of airway hyper responsiveness and goblet cell hyperplasia. The protective role of Apo E pathways primarily in respiratory disease was explained in human studies and research utilizing experimental murine model systems. Literature data reveal a strong association between redox status, including the enzyme superoxide dismutase (SOD) with both the development a severity of OLD. This study aims to investigate the relation between SOD antioxidant enzyme activity in addition to investigating the level of Apo E and the development of obstructive lung diseases (OLD). Methods Patients with OLD (n = 40) and 40 age-matched healthy controls were enrolled in this study. Serum samples were collected to test the role of Apo E and to test the effect of antioxidant enzyme SOD, and their influence on OLD, all measured by ELISA.Result The results showed a significant decrease in the level of serum SOD activity in patients with OLD when compared with control group (P < 0.05). However, the levels of Apo E did not show a significant difference between the two groups. Conclusion Decreased level of antioxidant SOD suggests the presence of an oxidative stress in asthmatic airways favoring a more oxidative state is present in the airway inflammation. The level of Apo E was non significantly increased in serum of patient, this suggests that protein level of Apo E does not change but may be Apo E gene expression is altered.

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Evaluation of pharmacological activities and assessment of intraocular penetration of an ayurvedic polyherbal eye drop (Itone™) in experimental models

Cited by 217 publications

References 28 publications

Antiangiogenic, wound healing and antioxidant activity ofCladosporium cladosporioides(Endophytic Fungus) isolated from seaweed (Sargassum wightii)

Antiangiogenic, wound healing and antioxidant activity ofCladosporium cladosporioides(Endophytic Fungus) isolated from seaweed (Sargassum wightii)

Molecular Mechanisms of Casticin Action: an Update on its Antitumor Functions

Role of Apo E and superoxide dismutase in patients with obstructive lung diseases

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