Evaluation of performance of the Omni mode for detecting video capsule endoscopy images: A multicenter randomized controlled trial

Abstract

Background and study aims: Olympus recently developed a new algorithm called Omni mode that discards redundant video capsule endoscopy (VCE) images. The current study aimed to demonstrate the non-inferiority of the Omni mode in terms of true positives (TPs) and the superiority of the Omni mode with regard to reading time against a control (ordinary ES-10 system). Patients and methods: This multicenter prospective study included 40 patients with various small bowel diseases. VCE images were evaluated by 7 readers and 3 judging committee members. Two randomly allocated readers assessed the VCE images obtained using the 2 modalities for each patient. The order of the modalities was switched between the 2 readers and the interval between readings by the same reader was 2 weeks. The judging committee predefined clinically relevant lesions as major lesions and irrelevant lesions as minor lesions. The number of TPs for major and minor lesions and the reading times were compared between the modalities. The predefined non-inferiority margin for the TP ratio of the Omni mode compared with the control was 0.9. Results: The estimated TP ratios and 95 % confidence intervals for total, major, and minor lesions were 0.87 (0.80 – 0.95), 0.93 (0.83 – 1.04), and 0.83 (0.74 – 0.94), respectively. Although non-inferiority was not demonstrated, the rate of detection of major lesions was not significantly different between the modalities. The reading time was significantly lower when using the Omni mode than when using the control. Conclusions: The Omni mode may be only appropriate for the assessment of major lesions.

Capsule endoscopy for small‐intestinal disorders: Current status

“…We conducted a multicenter study in Japan and reported the efficacy of omni mode. 36 We did not demonstrate non-inferiority between using control (normal reading) and omni mode. However, detection of major lesions was not significantly different between control and omni modes.…”

“…Omni mode can select and discard redundant images, and display all the areas captured by SBCE. We conducted a multicenter study in Japan and reported the efficacy of omni mode . We did not demonstrate non‐inferiority between using control (normal reading) and omni mode.…”

“…Data courtesy of Olympus. Reproduced from Hosoe et al ., with permission. Omni mode compares the target image with reference image A and analyzes the areas of the target image covered by reference image A.…”

“…The EndoCapsule platform of Olympus has developed CE reading software named auto-speed-adjusted, expressselected playback, 35 overview function and omni modes. 36 The overview function displays a selection of characteristic still images of the CE procedure on a single page. These pictures are selected by comparing pictures with changes from a previous picture; then, pictures with the most changes are selected and displayed.…”

Optimising the performance and interpretation of small bowel capsule endoscopy

“…This software has been recently superseded by the Omni mode, which claims to be able to reduce the images displayed by 65% through the ‘intelligent’ removal of repeated as well as overlapping images. To date this has been studied in a Japanese multicentre trial, which showed that this software was able to correctly remove images while maintaining all the preidentified major lesions in 40 selected cases 52. A larger multicentre European study is currently underway.…”