Evaluation of PCSK9 levels and its genetic polymorphisms in women with polycystic ovary syndrome

Xavier, Luana B.; Sóter, Mirelle O.; Sales, Mariana F.; Oliveira, Daisy K. D. de; Reis, Helton José; Cândido, Alexandre Luna; Reis, Fernando M.; Silva, Ieda O.; Gomes, Karina Braga; Ferreira, Cláudia N.

doi:10.1016/j.gene.2017.11.006

Cited by 19 publications

(30 citation statements)

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“…This protein acts by preventing the recycling of LDL receptors (LDL-r) back to the cell surface and thus generates higher levels of LDLc. Recently, we demonstrated that the GG genotype in PCSK9 rs562556 polymorphism was associated with higher HDL-c in PCOS women, while AA genotype carriers had higher plasma testosterone levels, suggesting the relationship between dyslipidemia and androgenic status in PCOS women (Xavier et al 2018).…”

Section: Pathophysiology Of Pcosmentioning

confidence: 93%

“…Women with PCOS present a higher risk of obesity (in particular the visceral phenotype), dyslipidemia, insulin resistance (IR) with compensatory hyperinsulinemia, type 2 diabetes mellitus (T2DM), metabolic syndrome and cardiovascular complications (Palomba et al 2015;Silva et al 2015;Azziz et al 2016;Pavaleanu et al 2016;Carvalho et al 2017a;Papadakis et al 2017;Xavier et al 2018). Another relevant complication is infertility due to chronic anovulation (Joham et al 2015; Glintborg and Andersen 2017) ( Figure 1).…”

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confidence: 99%

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Polycystic Ovary Syndrome as a systemic disease with multiple molecular pathways: a narrative review

Carvalho

Reis

Cândido

et al. 2018

Endocrine Regulations

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Polycystic Ovary Syndrome (PCOS) is characterized by hyperandrogenism, amenorrhea, and polycystic ovaries. This endocrinopathy is associated with many metabolic disorders such as dyslipidemia and insulin resistance, with increased risk of type 2 diabetes mellitus, metabolic syndrome, and cardiovascular complications. Inflammation is likely to play an important role in the promoting these metabolic imbalances, while prothrombotic and pro-oxidative mechanisms further contribute to the cardiovascular risk of these patients. The etiology of PCOS is still not fully understood, but there is evidence of genetic and environmental components. This review aims to discuss some molecular pathways associated with PCOS that could contribute to the better understanding about this syndrome. Recent evidence suggests that intrauterine exposure of female mice to an excess of anti-Müllerian hormone may induce PCOS features in their post-natal life. High cytokine levels and cytokine gene polymorphisms also appear to be associated with the pathophysiology of PCOS. Furthermore, high levels of microparticles may contribute to the altered hemostasis and enhanced inflammation in PCOS. All these mechanisms may be relevant to clarify some aspects of PCOS pathogenesis and inspire new strategies to prevent the syndrome as well as treat its symptoms and mitigate the risk of long-term complications.

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Section: Pathophysiology Of Pcosmentioning

confidence: 93%

mentioning

confidence: 99%

Polycystic Ovary Syndrome as a systemic disease with multiple molecular pathways: a narrative review

Carvalho

Reis

Cândido

et al. 2018

Endocrine Regulations

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“…Among them, only 15 articles were with respect to rs562556 polymorphisms [17, 19–32]. After applying inclusion and exclusion criteria, 7 eligible articles published between 2004 and 2017 were included in the final meta-analysis model [19, 22, 23, 26, 27, 30, 32]. The main features of all the included studies were summarized in Table 1.…”

Section: Resultsmentioning

confidence: 99%

The association of the PCSK9 rs562556 polymorphism with serum lipids level: a meta-analysis

et al. 2019

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Background Studies had investigated the associations between proprotein convertase subtilisin/kexin type 9 SNP rs562556 and serum lipids levels and response to statin treatment, however, the results remained inconclusive. We conducted this meta-analysis to elucidate the relationship of rs562556 and serum lipids levels. Methods All eligible studies met the inclusion criteria were retrieved from multiple databases. Relative data were extracted from each study. Review Manager (version 5.3.5) and STATA 12.0 software was used to perform this meta-analysis. Pooled standardized mean difference (SMD) with 95% CI was employed to evaluate the association of rs562556 with serum lipids levels. Results A total of 7 eligible articles involving 4742 subjects were included in the final meta-analysis. The results revealed that the G carriers had lower levels of total cholesterol (SMD: 0.14, 95% Cl: 0.06–0.23, P = 0.001) and LDL-C(SMD: 0.13, 95% Cl: -0.55-0.22, P = 0.002) than the non-carriers. The statistical results also illustrated that the G carriers had lower relative risk (SMD: 1.38, 95% Cl: 1.02–1.85, P = 0.003) than the non-carriers. Conclusions The results of the current meta-analysis for the first time indicated the relevance of rs562556 and lower serum cholesterol levels. Electronic supplementary material The online version of this article (10.1186/s12944-019-1036-1) contains supplementary material, which is available to authorized users.

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“…Table 1 summarizes the characteristics of studies on Brazilian populations. Seven studies were from the Northeast region [23][24][25][26][27][28][29], thirteen studies were from the Southeast [30][31][32][33][34][35][36][37][38][39][40][41][42], five studies were from the South [43][44][45][46][47], and two studies were from the Midwest region [48,49]. No data from the North region were available.…”

Section: Discussionmentioning

confidence: 99%

“…In Brazilian women with PCOS, BMI ranged from 24.2 to 31.9 kg/m 2 ( Table 2). In studies without a BMImatched control group, most PCOS groups had higher BMI than controls [23,24,31,35,[42][43][44][45][46]. The prevalence of obesity in Brazilian women with PCOS diagnosed by Rotterdam criteria was reported in eight studies [26,28,34,39,42,46,48,49].…”

Section: Discussionmentioning

confidence: 99%

Metabolic profile of women with PCOS in Brazil: a systematic review and meta-analysis

Spritzer

Ramos

Marchesan

et al. 2021

Diabetol Metab Syndr

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Background Polycystic ovary syndrome (PCOS) is a common endocrine disease affecting women of reproductive age and associated with reproductive and metabolic dysfunction. Few studies are available regarding metabolic traits in Brazilian women with PCOS. The aim of this systematic review and meta-analysis was to summarize the available evidence regarding metabolic traits and comorbidities in Brazilian women with polycystic ovary syndrome (PCOS). Methods We systematically searched PubMed, Cochrane Central Register of Controlled Trials, and Embase for cross-sectional, case–control, or cohort studies focusing on populations of different regions from Brazil, published until July 31, 2019. Studies were selected if they reported PCOS diagnostic criteria. Studies without a control group were included if they presented relevant metabolic data. Results Of 4856 studies initially identified, 27 were included in the systematic review and 12 were included in the meta-analysis, for a total of 995 women with PCOS defined by Rotterdam criteria and 2275 controls from different regions of Brazil. Obesity, metabolic syndrome and IGT were prevalent, and standard mean differences for BMI (SMD 0.67, 95% CI, 0.29, 1.05), waist circumference (SMD 0.22, 95% CI 0.02, 0.41), systolic (SMD 0.66, 95% CI 0.30, 1.01) and diastolic blood pressure (SMD 0.55, 95% CI 0.24, 0.87), glucose (SMD 0.21, 95% CI 0.04, 0.38) and HOMA (SMD 0.78, 95% CI 0.52, 1.04) were significantly higher in Brazilian women with PCOS compared to controls. Lipid profile was more adverse in PCOS vs. non-PCOS women. Between-study heterogeneities were low/moderate for glucose and HOMA and moderate/high for the other variables. Conclusions The data of this systematic review and meta-analysis indicate that Brazilian women with PCOS have a worse metabolic profile than women without PCOS with no important regional differences. The prevalence of metabolic changes is intermediate in Brazil vs. other countries.

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Evaluation of PCSK9 levels and its genetic polymorphisms in women with polycystic ovary syndrome

Cited by 19 publications

References 43 publications

Polycystic Ovary Syndrome as a systemic disease with multiple molecular pathways: a narrative review

Polycystic Ovary Syndrome as a systemic disease with multiple molecular pathways: a narrative review

The association of the PCSK9 rs562556 polymorphism with serum lipids level: a meta-analysis

Metabolic profile of women with PCOS in Brazil: a systematic review and meta-analysis

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