Evaluation of Parathyroid Hormone Bound to a Synthetic Matrix for Guided Bone Regeneration Around Dental Implants: A Histomorphometric Study in Dogs

Valderrama, Pilar; Jung, Ronald E.; Thoma, Daniel S.; Jones, Archie A.; Cochran, David L.

doi:10.1902/jop.2010.090562

Cited by 40 publications

(40 citation statements)

References 42 publications

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“…It has been tested in rats with induced osteoporosis, where it caused increased bone mineralization and formation in extraction sockets and prevented periodontal bone loss [125, 126]. In canine GBR, teriparatide improved bone formation around implants [127, 128]. …”

Section: Growth Factors and Protein Deliverymentioning

confidence: 99%

Tissue engineering for bone regeneration and osseointegration in the oral cavity

et al. 2015

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Section: Growth Factors and Protein Deliverymentioning

confidence: 99%

Tissue engineering for bone regeneration and osseointegration in the oral cavity

et al. 2015

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“…A study which was carried out on the acute defects which were created around dental implants in dogs at 2 weeks of healing, to evaluate the effect of PTH 1-34 which was covalently bound with a synthetic Polyethylene Glycol-based hydrogel, showed promising results [18].…”

Section: Outcomes Of Various Preclinical Studiesmentioning

confidence: 99%

eriparatide: A Novel Means to Ultimately Achieve True Regeneration!!!

Grover

Luthra²,

Maroo³

2013

JCDR

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ABSTRACT"Perioceutics" or the use of the pharmacological agents which are specifically developed to manage periodontitis, is an interesting and an emerging aid in the management of periodontal diseases, along with mechanical debridement. Host modulation therapies are being proposed and developed to bring down excessive levels of enzymes, cytokines, prostanoids, as well modulate osteoclast functions. Over the past two decades, many drugs have been investigated for their host modulating properties in both animal and early human clinical studies. These agents include non-steroidal anti-inflammatory drugs, sub antimicrobial dose doxycycline and systemic bisphosphonates. Recently, a new drug has been added to the list, namely, teriparatide, which is a bone forming drug. It is a biosynthetic human parathyroid hormone. Multiple clinical trials have shown that teriparatide is associated with increased bone mineral density. This review has focused on the mechanism of action of teriparatide and its potential role in the treatment of periodontal disease.www.jcdr.net Harpreet Singh Grover et al., Teriparatide & Periodontal Regeneration

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“…Several studies have investigated the effect of PTH on maxillofacial bone healing in animals without osteoporosis (Andreassen and Cacciafesta, 2004;Jung et al, 2007a,b;Valderrama et al, 2010). PTH was applied intermittently in combination with guided bone regeneration in a rat model (Andreassen and Cacciafesta, 2004).…”

Section: Animal Models Without Induced Osteoporosismentioning

confidence: 99%

“…Dry and ash weight as well as mechanical strength of tissue harvested from the defects were significantly higher with PTH administration. Locally delivered PTH was also used to facilitate bone regeneration (Jung et al, 2007a,b;Valderrama et al, 2010). Polyethylene-glycol matrices carrying PTH were applied to surgically created bony defects surrounding implants.…”

Section: Animal Models Without Induced Osteoporosismentioning

confidence: 99%

“…Several surgical techniques can be used at various stages of implant therapy to augment bone, e.g., socket/ridge augmentation, guided bone regeneration (GBR), block grafts, and distraction osteogenesis. Animal studies have demonstrated that PTH in combination with GBR and bone grafts could enhance alveolar bone formation (Andreassen and Cacciafesta, 2004;Jung et al, 2007a,b;Valderrama et al, 2010). In fact, alveolar bone, vs. other parts of the mandible and maxilla, has been found to be particularly responsive to PTH (Kawane et al, 2002).…”

Section: Dental Implant and Implant-related Bone Augmentation Proceduresmentioning

confidence: 99%

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Parathyroid Hormone Applications in the Craniofacial Skeleton

Chan

McCauley

2012

J Dent Res

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Parathyroid hormone (PTH) is known for its ability to ‘build’ bone, with research in this area centered on its use as an osteoporosis therapeutic. Recent interest has developed regarding its potential for regenerative applications such as fracture healing and osseous defects of the oral cavity. Many years of investigation using murine gene-targeted models substantiate a role for signaling at the PTH/PTH-related protein (PTHrP) receptor (PPR) in intramembranous bone formation in the craniofacial region as well as in tooth development. Pre-clinical studies clearly support a positive role of intermittent PTH administration in craniofacial bones and in fracture healing and implant integration. A few human clinical studies have shown favorable responses with teriparatide (the biologically active fragment of PTH) administration. Favorable outcomes have emerged with teriparatide administration in patients with osteonecrosis of the jaw (ONJ). New delivery strategies are in development to optimize targeted application of PTH and to help maximize local approaches. The promising host-modulating potential of PTH requires more information to further its effectiveness for craniofacial regeneration and osseous wound-healing, including a better delineation of cellular targets, temporal effects of PTH action, and improved approaches for local/targeted delivery of PTH.

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Evaluation of Parathyroid Hormone Bound to a Synthetic Matrix for Guided Bone Regeneration Around Dental Implants: A Histomorphometric Study in Dogs

Cited by 40 publications

References 42 publications

Tissue engineering for bone regeneration and osseointegration in the oral cavity

Tissue engineering for bone regeneration and osseointegration in the oral cavity

eriparatide: A Novel Means to Ultimately Achieve True Regeneration!!!

Parathyroid Hormone Applications in the Craniofacial Skeleton

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