Evaluation of Oxidative Stress Levels and Dynamic Thiol-disulfide Balance in Patients with Retinopathy of Prematurity

Erdal, Hüseyin; Demirtas, Mehmet Semih; KILIÇBAY, Fatih; Tunç, Gaffari

doi:10.1080/02713683.2023.2185569

Cited by 3 publications

(5 citation statements)

References 29 publications

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“…7,8 Several studies in the literature have shown that OS plays a critical role in the pathogenesis of various diseases. [9][10][11][12][13][14][15][16][17][18] Studies have shown that FD patients have increased lipid and protein damage and decreased antioxidant defense system as a result of OS. [19][20][21] Increased intracellular Gb3 causes OS, which increases the expression of cellular adhesion molecules 1 in vascular endothelial cells.…”

Section: Introductionmentioning

confidence: 99%

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Thiol/disulfide homeostasis as a new oxidative stress marker in patients with Fabry disease

Erdal

Turğut

2023

Journal of Investigative Medicine

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This is the first study to evaluate thiol-disulfide homeostasis and oxidative stress (OS) levels in patients with Fabry Disease (FD). This prospective study consists of 30 FD patients and 30 healthy controls. The dynamic thiol-disulfide homeostasis of patients and control groups was evaluated by using the new, cost-effective and fully automated colorimetric method. A total of 60 patients and controls were included the present study. A statistically significant difference was found between the patient and control groups for native and total thiol levels (p<0.001). In addition, disulfide levels were significantly higher in FD patients compared with the control group (p<0.003). Native thiol levels showed significanlty negative correlation with Lyso-Gb3, total oxidant status (TOS) and oxidative stress index (OSI) levels. In addition, a positive correlation was found between disulfide/natural thiol and disulfide/total thiol ratios and TOS, OSI and BUN. We found total antioxidant status (TAS) levels were lower in the patient group compared to the control group, while TOS and OSI levels were higher and were statistically significant. This study highlights for the first time a novel, cost-effective and fully automated measurement of thiol -disulfide levels in patients with FD. Dynamic thiol- disulfide levels may contribute to the etiopathogenesis and follow-up of the disease in patients with FD.

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Section: Introductionmentioning

confidence: 99%

“…22 Studies have shown the determination of dynamic thiol-disulfide balance as evidence of elevated OS. [9][10][11][12][13][14][15][16][17][18]23 This is the first study to show both dynamic thiol-disulfide balance and OS levels in FD patients.…”

Section: Introductionmentioning

confidence: 99%

Thiol/disulfide homeostasis as a new oxidative stress marker in patients with Fabry disease

Erdal

Turğut

2023

Journal of Investigative Medicine

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“…12,13 Thiols, which contain a sulfhydryl group attached to the carbon atom in their structure, are an important part of the antioxidant system. During OS, thiols undergo oxidation reactions to form disulfide structures, 4,14 which are then reduced back to thiol groups to achieve a thiol-disulfide balance. 11 Various studies have shown that the thiol-disulfide balance levels act as an indicator of increased free radical levels, and this balance can also be used as an indicator of OS due to an increase in free radicals.…”

Section: Introductionmentioning

confidence: 99%

“… 11 Various studies have shown that the thiol–disulfide balance levels act as an indicator of increased free radical levels, and this balance can also be used as an indicator of OS due to an increase in free radicals. 4 , 14 – 16 An abnormal thiol–disulfide balance is associated with the pathogenesis of many diseases. 16 – 19 The aim of this study was to evaluate the effects of delivery mode on the neonatal thiol–disulfide balance and OS levels.…”

Section: Introductionmentioning

confidence: 99%

Effect of mode of delivery on neonatal oxidative stress and dynamic thiol–disulfide homeostasis

Genc,

Erdal

2023

J Int Med Res

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Objective To evaluate the effect of the mode of delivery on neonatal oxidative stress and dynamic thiol–disulfide homeostasis. Methods Sixty women who were followed up in the Obstetrics and Gynecology clinic were included in this prospective study. Cord blood samples were obtained from women who underwent cesarean section (CS) and vaginal delivery (VD). Total oxidant status and total antioxidant status levels were measured by spectrophotometry. The dynamic thiol–disulfide balance was determined by colorimetry. Results The total antioxidant status and oxidative stress index levels were higher and total oxidant status levels were lower in the VD group compared with the CS group. Native and total thiol levels were higher while disulfide levels were lower in the VD compared with the CS delivery group, while disulfide levels were higher in the CS group. Conclusion These results indicate that disulfide formation leads to decreased antioxidant capacity in women undergoing CS. Monitoring of dynamic thiol–disulfide levels may thus provide clinicians with important information on the oxidative stress status in newborns.

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“…Studies have shown that abnormal thiol-disulfide levels play a crucial role in the pathogenesis of many diseases. [11][12][13][14][15][16][17][18][19][20] Therefore, determination of dynamic thiol-disulfide balance can provide vital information about biochemical processes. The modification that occurs in albumin as a result of the increase in OS reduces the binding capacity of albumin.…”

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Thiol-Disulfide Homeostasis and Ischemia Modified Albumin as a New Oxidative Stress Marker in Patients with Polycythemia Vera

Erdal

2023

EJMI

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P olycythemia Vera (PV) is a chronic myeloproliferative disease characterized by increased red blood cells or erythrocytosis originating from hematopoietic stem cells. [1][2][3] PV was first described in 1892 and its age-related incidence rate is 2.5-10/100,000 people. [4] The mean age at diagnosis is generally 60 years old in male patients. The diagnostic criteria of the World Health Organization (WHO) include elevated hemoglobin or hematocrit levels, abnormal results on bone marrow biopsy, and the presence of the JACK 2 genetic mutation, which is found in approximately 98% of cases. The majority of PV patients have a mutation in the Janus-type tyrosine kinase-2 (JAK2) gene. [3] A below-normal level of erythropoietin distinguishes PV from common secondary causes of erythrocytosis such as smoking, sleep apnea, and testosterone use. [5] The precise mechanism of uncontrolled cell growth in PV has not been clarified, although the consequences of tyrosine kinase activations due to JAK2-dependent mutation are known. In Objectives: The present study aims to indicate both thiol-disulfide hemostasis and ischemia-modified albumin (IMA) levels in patients with Polycythemia Vera (PV). Methods: In this prospective case-control study, 34 PV patients and 31 healthy control participants were included. Thiol levels were measured with a new modified colorimetric method. IMA levels were determined by cobalt binding test. Results: Thiol levels were statistically significant between the groups. (p<0.001). IMA levels were also significanlty higher in PV group than healthy control subjects (p<0.001). We revealed that thiol and IMA levels were significantly higher in patients with PV in respect to the control groups. Conclusion:The obtain results indicate that the oxidative balance is disturbed and changed towards the oxidant direction. The dynamic-thiol disulfide balance has moved to proliferation side in patients with PV, and may provide important contributions to the patient's follow-up and disease pathophysiology.

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Evaluation of Oxidative Stress Levels and Dynamic Thiol-disulfide Balance in Patients with Retinopathy of Prematurity

Cited by 3 publications

References 29 publications

Thiol/disulfide homeostasis as a new oxidative stress marker in patients with Fabry disease

Thiol/disulfide homeostasis as a new oxidative stress marker in patients with Fabry disease

Effect of mode of delivery on neonatal oxidative stress and dynamic thiol–disulfide homeostasis

Thiol-Disulfide Homeostasis and Ischemia Modified Albumin as a New Oxidative Stress Marker in Patients with Polycythemia Vera

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