Evaluation of Oxidative Status and Inflammatory Changes in Naturally Occurring Canine Visceral Leishmaniasis

Aşkar, Tünay Kontaş; Aşkar, Şinasi; Büyükleblebici, Olga; Güzel, Murat

doi:10.17582/journal.pjz/2019.51.1.301.306

Cited by 6 publications

(4 citation statements)

References 14 publications

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“…These clinical, hematological, and biochemical ndings were found to be consistent with the literature (Solano- In this study, it was found that NO concentration was higher in the Stage II, III, and IV groups compared to the healthy and Stage I groups. The increase in nitric oxide levels in dogs with CanL has also been reported in previous studies (Baldissera et al 2015;Askar et al 2019). It is suggested that this may be a part of the oxidative and in ammatory process related to the disease, and one of the main factors contributing to the increase is the release of nitric oxide during the phagocytosis of L. infantum amastigotes by macrophages (Panaro et al 2008).…”

Section: Discussionsupporting

confidence: 72%

Arginine, symmetric and asymmetric dimethylarginine levels in canine leishmaniasis

Gultekin

Paşa

Ural

et al. 2023

Microbial Pathogenesis

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Section: Discussionsupporting

confidence: 72%

Arginine, symmetric and asymmetric dimethylarginine levels in canine leishmaniasis

Gultekin

Paşa

Ural

et al. 2023

Microbial Pathogenesis

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“…), hydrogen peroxide (H 2 O 2 ) and hydroxyl radicals (.OH) and reactive nitrogen species (RNS), e.g. NO, in response to phagocytosis by monocytes/macrophages as a host defense mechanism for killing of engulfed Leishmania [22,23]. Furthermore, the reduction in the blood GSH-Px activity in untreated CL patients compared to the results of control and treated patients groups (Fig.…”

Section: Discussionmentioning

confidence: 92%

Evaluation of immune cellular enzymes, oxidative and nitrosative Stress in Saudi Patients with Cutaneous Leishmaniasis in Al-AHssa, before and after treatment

Saif

Al-Mohammad

2020

Preprint

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Background Macrophages, within which Leishmania sp. replicate, generate large amounts of reactive oxygen species (ROS) and reactive nitrogen species (RNS) to kill these parasites. Methods The aim of the present study was to assess oxidative, nitrosative stresses, and some immune enzymes in blood of cutaneous leishmaniasis (CL) patients before and after treatment as well as in control individuals. Serum activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidas (GSH-Px) and the levels of reduced glutathione, malondialdehyde (MAD) and nitric oxide (NO) as well as L-arginase, myeloperoxidase (MPO), adenosine deaminase (ADA) have been studied. Results The activities of the L-arginase, MPO and ADA, the levels of MDA and NO are significantly elevated (P < 0.001), while that of SOD, CAT, and GSH-Px, and GSH level were significantly (P < 0.001) reduced in untreated patients compared with the corresponding activities of the treated and control individuals. The treatment ameliorated these agents in comparison to the untreated group but there was still variations between the values of treated and control groups. Conclusion These results suggested that oxidative and nitrusative stress may play an important role in the pathogenesis of untreated cutaneous leishmaniasis

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“…Many studies, including CanVL (6,7,10,11,33,62,63), claim that reactive oxygen species (ROS) play a role in the pathogenesis of various infectious and parasitic diseases in dogs (14,23,37,40,59,70). Excessive ROS production leads to oxidative stress as a result of imbalance between oxidants and antioxidants.…”

Section: Investigation Of Dna Damage and Protein Damage Caused By Oxidative Stress In Canine Visceral Leishmaniasismentioning

confidence: 99%

Investigation of DNA damage and protein damage caused by oxidative stress in canine visceral leishmaniasis

Kiral¹,

Sekkin²,

Paşa³

et al. 2021

Medycyna Weterynaryjna

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Leishmaniasis, considered by the World Health Organization as one of the most important zoonotic diseases, causes death when it is not treated in its self-healing skin form. The aim of this study was to investigate DNA damage and oxidative protein damage that occurs in dogs infected with Leishmania infantum. The study group consisted of 25 dogs, including 10 clinically healthy dogs aged 2 to 6 years and 15 dogs infected with Leishmania infantum diagnosed by means of the rk39 dipstick test and the immunofluorescence antibody test (IFAT). The effects of oxidative stress on protein were evaluated in the dogs infected with Leishmania infantum by determining plasma malondialdehyde, protein carbonyl groups, nitrotyrosine, and total antioxidant capacity in blood. DNA damage, on the other hand, was determined by the COMET method. Plasma protein carbonyl content (PCO) and nitrotyrosine (NT) levels, which are considered as indicators of protein damage, were found to be higher in the dogs infected with Leishmania infantum compared to the control group, but the difference in both values was not statistically significant (p > 0.05). Plasma malondialdehyde (MDA), an indicator of lipid peroxidation, was significantly higher in the dogs infected with Leishmania infantum than in the control group. TAC levels, however, were lower in the leishmanial dogs (p < 0.05). According to the results of the COMET assay, lymphocyte cells were damaged in the leishmanial dogs, and both tail intensity (TI) and tail moment (TM) values were higher in those dogs than they were in the control group (p < 0.05, p < 0.01). The parasites caused oxidative stress through protein and DNA damage in the host and decreased the antioxidant capacity concentration that prevents destructive effects.

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Evaluation of Oxidative Status and Inflammatory Changes in Naturally Occurring Canine Visceral Leishmaniasis

Cited by 6 publications

References 14 publications

Arginine, symmetric and asymmetric dimethylarginine levels in canine leishmaniasis

Arginine, symmetric and asymmetric dimethylarginine levels in canine leishmaniasis

Evaluation of immune cellular enzymes, oxidative and nitrosative Stress in Saudi Patients with Cutaneous Leishmaniasis in Al-AHssa, before and after treatment

Investigation of DNA damage and protein damage caused by oxidative stress in canine visceral leishmaniasis

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