Evaluation of Oxidant–Antioxidant Balance in Children with Atopic Dermatitis: A Case–Control Study

Uysal, Pınar; Avcıl, Sibelnur; Abas, Burçin İrem; Yenisey, Cigdem

doi:10.1007/s40257-016-0210-8

Cited by 19 publications

(36 citation statements)

References 44 publications

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“…In the papers considered in our review, MDA was the most frequently measured marker of oxidative stress, in different types of samples. Compared to those found in healthy controls, serum levels of MDA of AD patients were significantly higher in two of four studies [25,26] and not significantly different in the other two [22,38]. Urinary MDA was evaluated in one paper [37] and, although the difference between patients and controls was not significant, a correlation was observed between MDA levels and AD severity and extent.…”

Section: Biomarkersmentioning

confidence: 78%

“…In detail, four studies were published in the 1990s, nine in the 2000s, and 21 in the last decade. Different geographical areas (and ethnicities) were not uniformly represented: 16 studies [17,18,23,24,27,[32][33][34][35][36][37][38]40,42,45,46] were performed in Eastern Asia (8 in Japan, 6 in Korea, 2 in Taiwan), nine [21,28,31,39,41,43,44,47,48] in Europe (3 in Russia, 2 in Germany, 1 in Finland, Italy, Norway, Switzerland), four [20,22,29,30] in Middle Eastern countries (3 in Turkey, 1 in Israel), two [25,26] in Southern Asia (Bangladesh, India), and one [49] in the United States of America. Another study [19] included patients from multiple Canadian and European centers.…”

Section: Resultsmentioning

confidence: 99%

“…Many other parameters related to oxidative stress were evaluated in only one of the papers corresponding to the selection criteria used for this review. In the serum of AD patients, significantly elevated levels of clusterin (correlated with disease severity) [24], significantly decreased levels of beta carotene [34], catalase [26], gamma tocopherol [39], glutathione peroxidase [26], Mg [30], NO [22], retinol [34], and levels of Cu similar to those of healthy controls [30] were found. Decreased also were, in AD patients, the serum total antioxidant capacity [38], serum disulphide, disulphide/native thiol ratio and disulphide/total thiol ratio [20], NO/melatonin ratio [22], nitrite/nitrate (NO x -) [45].…”

Section: Biomarkersmentioning

confidence: 99%

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Oxidative Stress and Atopic Dermatitis

et al. 2020

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Atopic dermatitis is a common chronic/chronically relapsing inflammatory skin disease, with increasing worldwide prevalence. Etiopathogenesis is complex and multifactorial, with a mix of genetic, immunological and environmental aspects. Like in other chronic inflammatory diseases, oxidative stress plays an important pathogenetic role. We reviewed in vivo research studies on humans about oxidative stress and atopic dermatitis. Although sometimes contrasting, overall, they suggest that oxidative stress may have a significant role in atopic dermatitis, but our understanding is still incomplete, at least concerning in vivo data, because of limitations of available literature. Research consists of 33 papers published in 28 years, was not always performed on large study populations, represents a limited number of countries and ethnicities—not always in proportion to their size—and is scattered over multiple papers that, in the majority of cases, cannot be pooled and/or compared because many biomarkers were studied, in different tissues and with different methods. Further, larger studies appear warranted and necessary to shed more light on this aspect of atopic dermatitis, which is important not only to improve our understanding of this disease, but also for potential clinical and therapeutic implications.

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Section: Biomarkersmentioning

confidence: 78%

Section: Resultsmentioning

confidence: 99%

Section: Biomarkersmentioning

confidence: 99%

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Oxidative Stress and Atopic Dermatitis

et al. 2020

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“…Another way to get the oxidizing/antioxidant ratio is to measure the oxidants like superoxide anion (O 2 −· ) and nitric oxide (NO), and glutathione (GSH) or melatonin as antioxidants, although their use should not be frequent, because it exists only one report about melatonin in which it was calculated the NO/melatonin and MDA/melatonin ratios; the authors suggest that these ratios reflect an oxidant-antioxidant balance and could be used to determine OS homeostasis [25], but we should consider that within the OS homeostasis, melatonin is not one of the essential markers. On the other hand, if we calculate the ratio with the oxidants (O 2 −· , NO 2 − ) and GSH as the antioxidant, a problem may arise because the measurement of the oxidants is not easy to apply at patient samples; thus, there remains doubt about its possible usefulness [26].…”

Section: Resultsmentioning

confidence: 99%

Oxidative Stress Indexes for Diagnosis of Health or Disease in Humans

Sánchez-Rodrı́guez

Mendoza-Núñez

2019

Oxidative Medicine and Cellular Longevity

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Oxidative stress (OS) is the imbalance between oxidant and antioxidant molecules, in favor of oxidants, that causes aging and disease. Many studies have been published that demonstrate the relationship between OS and human health and disease; however, the following questions arise: (i) how are we sure that the OS is present in a biological process? (ii) Is the OS reported in the different investigations equivalent? (iii) What are the best oxidant and antioxidant markers for OS diagnosis? (iv) Can we establish the types and the intensity of the OS? (v) Does OS index could be useful for research and/or application in clinical medicine? In this regard, several indexes have been proposed to measure OS in humans relative to the state of health and disease, among which the following can be highlighted: Oxidative Stress Index (OSI), Tiol Ratios (-SH/TT, -SS/-SH, and-SS/TT), Glutathione Ratio (GSSG/GSH), Oxidative Stress Score (OSS), and OXY-index. Therefore, the aim of this review is to present the state of the art of knowledge about OS indexes for diagnosis of health or disease in humans. We searched for articles in English or Spanish in the PubMed/MEDLINE and Scopus electronic databases published up until May 2019. The keywords used were “oxidative stress,” “index,” and “oxidative stress index.” It was identified 11479 records in both databases, and 490 articles were analyzed. Our review suggests that all indexes analyzed allow diagnose and differentiate the OS related to human health and disease. Also, the studies on OSI, Oxy-score, and OSS indexes have proven to be reliable, practical, and with clinical utility. However, it is necessary to continue with longitudinal studies, especially assess the usefulness of the indexes in the clinical prognosis, and make comparative studies between the different indexes.

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“…For a parameter to be valid, it is important that validation studies are done. Although nitric oxide/melatonin and malondialdehyde/melatonin ratios have been used in a previous study by the current authors to evaluate the oxidant–antioxidant balance, advanced validation studies have not been conducted (Uysal, Avcil, Abas, & Yenisey, 2016).…”

Section: Introductionmentioning

confidence: 99%

Elevated Melatonin Levels in Children With Attention Deficit Hyperactivity Disorder: Relationship to Oxidative and Nitrosative Stress

et al. 2019

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Objective: The aim of this article is to measure serum antioxidant melatonin, the oxidants of nitric oxide, and malondialdehyde levels to calculate the serum oxidant–antioxidant balance based on the nitric oxide/melatonin and malondialdehyde/melatonin ratios in children with ADHD. Method: The serum melatonin, nitric oxide, malondialdehyde, and the nitric oxide/melatonin and malondialdehyde/melatonin ratios were calculated and compared between the children with ADHD ( n = 103) and healthy control participants ( n = 73). Results: Serum melatonin and nitric oxide levels were higher, and the nitric oxide/melatonin and malondialdehyde/melatonin ratios were lower in ADHD children than the control group. Melatonin was found to be significantly high, and the malondialdehyde/melatonin ratio was found to be significantly low in children with a positive ADHD family history. Conclusion: The serum oxidant–antioxidant balance was impaired in children with ADHD. Within the ADHD group, higher melatonin levels were determined in the children with a positive family history.

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Evaluation of Oxidant–Antioxidant Balance in Children with Atopic Dermatitis: A Case–Control Study

Cited by 19 publications

References 44 publications

Oxidative Stress and Atopic Dermatitis

Oxidative Stress and Atopic Dermatitis

Oxidative Stress Indexes for Diagnosis of Health or Disease in Humans

Elevated Melatonin Levels in Children With Attention Deficit Hyperactivity Disorder: Relationship to Oxidative and Nitrosative Stress

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