Evaluation of orange‐brown precipitate formed in root canals after irrigation with chlorhexidine and QMix and spectroscopic analysis of precipitates produced by a mixture of chlorhexidine/NaOCl and QMix/NaOCl

Abstract

QMix(™) does not form para-chloroaniline when associated with NaOCl.

Combined and independent cytotoxicity of sodium hypochlorite, ethylenediaminetetraacetic acid and chlorhexidine

“…, Arslan et al . ), which causes dentine discoloration (Marchesan et al . ), occlusion of dentinal tubules (Bui et al .…”

“…, Arslan et al . )a likely carcinogenic and toxic compound (Chhabra et al . , Burkhardt‐Holm et al .…”

Comments on misinterpretation of the proton nuclear magnetic resonance spectroscopic data of a previous study

“…We would like to comment to the research article by Arslan et al () entitled ‘Evaluation of orange‐brown precipitate formed in root canals after irrigation with chlorhexidine and QMix and spectroscopic analysis of precipitates produced by a mixture of chlorhexidine/NaOCl and QMix/NaOCl’ which was published in the International Endodontic Journal in 2015. The authors aimed to analyse the precipitate produced by mixing chlorhexidine (CHX) and QMix (QMix 2in1, Tulsa Dental, Dentsply, OK, USA) with sodium hypochlorite (NaOCl) utilizing proton nuclear magnetic resonance (1H‐NMR) analysis.…”

“…In the materials and methods, Arslan et al () cited a previous study protocol (Thomas & Sem ) for 1H‐NMR spectroscopy in their ‘Materials and Methods’. However, there are major methodological differences between Arslan et al () and Thomas & Sem () as the latter used pure para‐chloroaniline (PCA) as the ‘internal standard’ or ‘control’ in their 1H‐NMR spectroscopy study. Spectral data (peaks of the spectrum pattern as singlet, doublet, etc.)…”

“…In the results, Arslan et al () stated that ‘According to the 1H NMR spectra, para‐chloroaniline was determined to be present from the mixture of chlorhexidine and NaOCl (Fig. 1).…”