Evaluation of oral therapy on Mansonial Schistosomiasis using single dose of Balanites aegyptiaca fruits and praziquantel

Koko, Waleed S.; Abdalla, H S; Galal, M.; Khalid, Hassan S.

doi:10.1016/j.fitote.2004.08.003

Cited by 36 publications

(20 citation statements)

References 6 publications

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“…Koko et al (2005) determined the efficacy of oral therapy with Balanites aegyptiaca fruit mesocarp in a dose of 200 mg=kg body weight of mice infected with Sudanese strain of S. mansoni, and found a significant reduction in egg count per gram of feces. Ramadan et al (2004) studied the therapeutic effect of Ferula assafoetida on S. mansoni in experimentally infected mice.…”

Section: Resultsmentioning

confidence: 99%

Large-scalein Vitro. Screening of Egyptian Native and Cultivated Plants for Schistosomicidal Activity

Yousif

Hifnawy

Soliman

et al. 2007

Pharmaceutical Biology

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In vitro bioassay screening of 346 methanol extracts originated from 281 native and cultivated plant species growing in Egypt, and related to 81 families, was carried out for schistosomicidal activity. The extracts were bioassayed at 100 mg=mL on viable Schistosoma mansoni mature worms in culture medium. Viability of worms was examined after exposure for 24 h, and mortality determined. Negative (DMSO) and positive (praziquantel) controls were used. Of the tested plant extracts, 72 were found to possess reproducible in vitro antischistosomal activity. These active extracts were further subjected to determination of their LC 50

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Section: Resultsmentioning

confidence: 99%

Large-scalein Vitro. Screening of Egyptian Native and Cultivated Plants for Schistosomicidal Activity

Yousif

Hifnawy

Soliman

et al. 2007

Pharmaceutical Biology

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“…On the other hand, no data dealing with the action of B. aegyptiaca extract on nematodes and cestodes have been reported. Only two publications concerning its promising efficacy against fasciolosis (Koko et al 2000) and schistosomiasis (Koko et al 2005) were available. Recent study had shown that methanolic extract of B. aegyptiaca fruits mesocarps contained high amounts of saponins (Wiesman and Chapagain 2006), so the high efficacy of the extract against parental stages of T. spiralis might be attributed to the presence of saponin compounds in B. aegyptiaca fruits.…”

Section: Discussionmentioning

confidence: 99%

Effect of methanolic extract of Balanites aegyptiaca fruits on enteral and parenteral stages of Trichinella spiralis in rats

Shalaby

Moghazy

Shalaby³

et al. 2010

Parasitol Res

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There is a considerable interest in developing new anthelmintic drugs including those from medicinal plants due to increasing evidence of parasitic resistance against present anthelmintic drugs and decreasing activity against encapsulated larval stages of parasites. This study was carried out to assess, for the first time, the effectiveness of methanolic extract of Balanites aegyptiaca (BAE) fruits against different stages (pre-adult, migrating larvae, and encysted larvae) of Trichinella spiralis in rats compared with commonly used anthelmintic albendazole. Oral administration of BAE at a dose of 1,000 mg/kg b.wt. for five successive days throughout the parasite life cycle led to a marked reduction of migrating and encysted larval rate by 81.7% and 61.7%, respectively, in the muscular tissue. This treatment was less effective against adults in the gut (47.8%). Albendazole treatment at a dose of 10 mg/kg b.wt. for five successive days resulted in a marked eradication of T. spiralis adult worms (94.4%) and less reduction of migrating and encysted larval infections of skeletal muscles (62.2% and 26.4%, respectively). BAE-treated groups showed marked decreases in serum-glucose levels, triglyceride concentrations, aspartate aminotransferase (AST), creatinine phosphokinase (CPK) activities, and lipid peroxide products (malondialdehyde, MDA) as well as an increase in glutathione level in both serum and muscular tissue compared to albendazole-treated- and infected-untreated groups. This result was confirmed by few numbers of living- and dead-encysted larvae and less destruction of the diaphragm and skeletal muscle tissues in BAE-treated groups compared to other treated groups. It can be concluded that the methanolic extract of B. aegyptiaca fruits has high effectiveness against parenteral stages of T. spiralis than albendazole. Albendazole is more effective against enteral stage of T. spiralis than the extract.

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“…[19][20][21][22][23] As infections with worms or molluscs represent a common affliction in that area, medicinal plants have been considered for treatment of these infections. [24][25][26][27] Immunomodulatory properties of Sudanese medicinal plants have also been observed. 28 In this review, we provide an updated overview of the most important plants used in Sudanese traditional medicines.…”

Section: Traditional Sudanese Medicinementioning

confidence: 99%

Gems from traditional north-African medicine: medicinal and aromatic plants from Sudan

Khalid

Abdalla

Abdelgadir

et al. 2012

Nat. Prod. Bioprospect.

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Sudanese folk medicine represents a unique blend of indigenous cultures with Islamic, Arabic and African traditions. In addition, Sudan encompasses different terrains and climatic zones, ranging from desert and semi-desert in the north to equatorial with a short rainy season (semi-aridand semi-humid) in the centre to equatorial with a long rainy season (arid-humid and equatorialhumid) in the south. This variation contributes to the immense diversity of vegetation in the region. The flora of Sudan consists of 3137 species of flowering plants belonging to 170 families and 1280 genera. It is estimated that 15% of these plants are endemic to Sudan. The intersection of diverse cultures and the unique geography holds great potential for Sudanese herbal medicine. Medicinal and aromatic plants and their derivatives represent an integral part of life in Sudan. Indigenous remedies are the only form of therapy available to the majority of poor people. It has been estimated that only 11% of the population has access to formal health care. Therefore, research on the desired pharmacological effects and possible unwanted side effects or toxicity is required to improve efficacy and safety of Sudanese herbal medicine. In the future, it would be preferable to promote the use of traditional herbal remedies by conversion of raw plant material into more sophisticated products instead of completely replacing the traditional remedies with synthetic products from industrialized countries. The present review gives an overview of traditional Sudanese medicinal and aromatic herbs and their habitats, traditional uses, and phytochemical constituents.

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Evaluation of oral therapy on Mansonial Schistosomiasis using single dose of Balanites aegyptiaca fruits and praziquantel

Cited by 36 publications

References 6 publications

Large-scalein Vitro. Screening of Egyptian Native and Cultivated Plants for Schistosomicidal Activity

Large-scalein Vitro. Screening of Egyptian Native and Cultivated Plants for Schistosomicidal Activity

Effect of methanolic extract of Balanites aegyptiaca fruits on enteral and parenteral stages of Trichinella spiralis in rats

Gems from traditional north-African medicine: medicinal and aromatic plants from Sudan

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