Evaluation of olfaction in patients with migraine using an odour stick identification test

Saisu, Akihiro; Tatsumoto, Muneto; Hoshiyama, Eisei; Aiba, Saiko; Hirata, Koichi

doi:10.1177/0333102411410612

Cited by 47 publications

(84 citation statements)

References 15 publications

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“…There were 13 comparative studies between migraine and other primary headaches or controls without headache, 2,3,5,8,13,14,[17][18][19][20]22,28,31 and 10 that evaluated only migraine patients. 4,6,7,11,15,16,24,26,29,30 As for odour-triggered headache, there were six studies detected, two comparative studies between migraine and other primary headaches, 1,3 two with migraine patients, 7,24 and two case reports. 9,12 However, there were six other studies where pathophysiological aspects of the association between odours and migraine were studied.…”

Section: Resultsmentioning

confidence: 99%

“…Generally, we observed a severe intolerance to odours, pleasant or unpleasant, during headache attacks. 2,[4][5][6][7][8]10,11,[13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30] However, a limited number of studies showed that odours may trigger headache attacks in some patients, particularly in migraineurs 1,3,6,7,9,24 and occasionally in cluster headache patients. 12,18 This intolerance to odours is known as osmophobia, and according to two studies that investigated osmophobia in secondary headaches, it occurred during headache attacks only in the primary headaches.…”

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confidence: 99%

“…2 Many researchers have confirmed that osmophobia is a symptom associated with migraine. 2,[4][5][6][7][8]10,11,[13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30] Despite such research, osmophobia is still not part of the diagnostic criteria for migraine. 34 In recent years, these studies were carried out in several countries.…”

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confidence: 99%

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Osmophobia and Odour-triggered Headaches – Review of the Literature and Main Research Centres

Silva‐Néto¹,

Soares²

2017

European Neurological Review

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There is an important relationship between odours and primary headaches. Patients may present osmophobia during headaches and odours may trigger headache attacks. This review aimed to describe the studies on osmophobia, odour-triggered headache, the main researchers and their research centres. Publications on the relationship between odours and primary headaches were searched in 193 sovereign countries and 48 dependent territories in all continents. We consulted the PubMed database and used the descriptors: "osmophobia in [name of the country or territory]"; "odours and headache in [name of the country or territory]" and "smell and headache in [name of the country or territory]". A total of 254 articles were found, but only 31 articles were considered relevant and composed this review. Of the 31 articles, 90.3% were cross-sectional studies, 6.5% case reports and 3.2% systematic reviews. All studies were performed on three continents: Europe (45.2%), America (32.2%) and Asia (22.6%). For the purpose of this study, North America and South America have been classed as one continent. No research was developed in Africa or Australia. More than 50.0% of the studies were conducted in Italy and Brazil. Only five authors published 38.7% of the studies. Osmophobia during headache attacks was investigated in 67.7% of studies, and odour-triggered headache in 19.3%. Studies on osmophobia and/or odour-triggered headache were carried out in several countries. They were useful in differentiating between migraine and tension-type headache. This could improve the accuracy of diagnosis of migraine compared to the current criteria.

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Section: Resultsmentioning

confidence: 99%

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confidence: 99%

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Osmophobia and Odour-triggered Headaches – Review of the Literature and Main Research Centres

Silva‐Néto¹,

Soares²

2017

European Neurological Review

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“…There is a significant association between odors and primary headaches, particularly to migraine with or without aura [1][2][3][4][5][6] and tension-type headache [1,[6][7][8]. The literature of its occurrence in secondary headaches is very scarce [9].…”

Section: Introductionmentioning

confidence: 99%

“…The literature of its occurrence in secondary headaches is very scarce [9]. They are triggers of headache attacks [2,10] or intolerance factor (osmophobia) [1] both during and between headache attacks (pain-free period) [1,3,11,12].…”

Section: Introductionmentioning

confidence: 99%

Phenytoin in the Treatment of Osmophobia in Migraine Patient: A Case Report

Silva‐Néto¹

2016

J Clin Case Rep

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Exploring the contributing factors to multiple chemical sensitivity in patients with migraine

Suzuki

Okamura

Haruyama

et al. 2022

Journal of Occupational Health

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Objective Multiple chemical sensitivity (MCS) is a form of chemical intolerance in which various systemic symptoms are triggered by exposure to a variety of chemical substances. Although migraine has been associated with central sensitivity syndrome, the relationship between MCS and migraine has not been studied. We assessed the frequency of MCS and its related factors in patients with migraine. Methods We performed a cross‐sectional study that included 95 patients (14 M/81 F; age, 45.4 ± 12.4 years) out of 100 consecutive patients with migraine from our outpatient headache clinic. MCS was defined as having a combination of Q1 ≥ 30, Q3 ≥ 13, and Q5 ≥ 17 on the quick environment exposure sensitivity inventory (QEESI; Japanese version). Central sensitization inventory‐A scores >40 were considered an indication of central sensitization. Headache‐related disability and psychological distress were evaluated with the Migraine Disability Assessment score (MIDAS) and Kessler Psychological Distress Scale (K6), respectively. Results MCS was identified in 20% of patients with migraine; however, none had previously been diagnosed with MCS. The MCS‐positive group had higher rates of photophobia, osmophobia, visual aura, sensory aura, and central sensitization and higher MIDAS and K6 scores than the MCS‐negative group. A logistic regression analysis showed that osmophobia, sensory aura, and central sensitization were significant contributors to MCS. Conclusion We showed that MCS was observed in 20% of patients with migraine, and our study results may indicate a possible association of MCS with central sensitization and hypersensitivity‐related symptoms in patients with migraine.

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Evaluation of olfaction in patients with migraine using an odour stick identification test

Abstract: The OSIT showed certain odours to be highly offensive to migraine patients even when they were not experiencing migraine headaches. More attention should be paid to odours that are perceived to be offensive by migraine patients, particularly those with MWA.

Cited by 47 publications

References 15 publications

Osmophobia and Odour-triggered Headaches – Review of the Literature and Main Research Centres

Osmophobia and Odour-triggered Headaches – Review of the Literature and Main Research Centres

Phenytoin in the Treatment of Osmophobia in Migraine Patient: A Case Report

Exploring the contributing factors to multiple chemical sensitivity in patients with migraine

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