Evaluation of Ointment Activity Based on Terminalia Mantaly Extract

Abstract

In Côte d'Ivoire pharmacopoeia the antifungal virtues of the bark of Terminalia mantaly are known. It bark is used to cure affections such as cutaneous candidiasis, gingivitis and diarrhoea. This work aims to compare the anticandidosic activities of the crude extract of T. mantaly and an ointment containing shea butter and the crude extract of T. mantaly. The anticandidosic activity of the crude Shea butter was also evaluated and kétoconazole was used as standards for antifungal assay.Shea butter, kétoconazole, crude extract of T. mantaly and the ointment were separately incorporated to Sabouraud agar using the agar slanted double dilution method. The anti-fungal tests were performed by sowing 1000 cells of Candida albicans on a previously prepared medium culture. Antifungal activity was determined by evaluating of anti-fungal parameters values (minimal fungicidal concentrations MFC and IC50).The results of the tests indicate that C. albicans is sensitive to each substance tested, however crude Shea butter has only fungistatic activity and the ointment (MFC= 1.874µg/mL) was the most active. This ointment is 52 times more active than the crude extract of T mantaly (MFC is of 97.5 µg/mL), 208.11 more active than kétoconazole (MFC = 390 µg/mL).

Endogenous Knowledge of the Attie People on AntiSchistosomiasis Medicinal Plants in the Adzope Health District, Côte d'Ivoire

“…Thereafter, the paste is applied to the tongue and inside the mouth of babies with stomatitis in Côte d'Ivoire (Sowemimoet al, 2012). Certainly, various studies conducted on the biological and phytochemical activities of Combretaceae have shown very good results (Soumahoro et al, 2016;Haïdara et al, 2022). Studies by Haïdara et al (2022) relating to the identification of chemical constituents and their antiradical activities of three Combretaceae revealed the richness of this botanical family in phytocompounds such as polyphenols, flavonoids, tannins, and compounds with triterpene genins such as saponosides which can justify biological activities.…”

Endogenous Knowledge of the Attie People on Antischistosomiasis Medicinal Plants in the Adzope Health District, Côte d'Ivoire

“…The leaf sap is used externally against gonorrhea in Tanganyika, while the galled leaves are crushed with salt and the paste applied to the tongue and inside the mouth of babies with stomatitis in Côte d'Ivoire (Sowemimo et al, 2012). Indeed, various studies conducted on the biological and phytochemical activities of Combretaceae have shown very good results (Soumahoro et al, 2016, Haïdara et al, 2022. Studies by Haïdara et al (2022) relating to the identification of chemical constituents and their antiradical activities of three Combretaceae revealed the richness of this botanical family in phytocompounds such as polyphenols, flavonoids, tannins and compounds with triterpene genins such as saponosides which can justify biological activities.…”

Evaluation of the antifungal powers of five plant species of the genus Terminalia on strains responsible for candidiasis

“…The active ingredients of T. ivorensis could substitute the classical molecules and cure the cases of resistant candidiasis. Previous works have shown that Terminalia are generally endowed with antifungal powers 17,18 and T. ivorensis is particularly very active, notably on Aspergillus fumigatus6 and Candida albicans. Therefore, this plant can be used in the composition of a biopesticide and a medical cream for its antifungal activity19,20 .…”