Evaluation of oesophageal transit in patients with minor peptic oesophagitis

Roland, J; Peters, O.; Piepsz, Amnon; Devis, Ghislain; Jonckheer, Marc; Ham, Hamphrey R.

doi:10.1097/00006231-198903000-00006

Cited by 7 publications

(3 citation statements)

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“…X‐ray (20,21), isotopic (22), and manometric (4,9,11,16,23) studies have shown that patients with esophagitis have deficient peristaltic activity with feeble and failed primary waves (4,15,24), delayed transit time of a semisolid isotopic meal (5), and prolonged acid clearance (13). The introduction of prolonged ambulatory esophageal motility coupled with pH probe study has confirmed the data obtained by stationary manometry.…”

Section: Discussionmentioning

confidence: 99%

Effect of Reflux and Esophagitis on Esophageal Volume and Acid Clearance in Piglets

Vicente,

da Rocha,

Perez‐Mies

et al. 2004

J. pediatr. gastroenterol. nutr.

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Background/aimsThe study investigates esophageal motor function and esophageal clearance immediately after surgical induction of reflux in piglets and 8 weeks later after peptic esophagitis has developed.MethodsTwenty‐four sedated, nonintubated piglets were divided into three groups: sham (laparotomy only), reflux (distal esophageal myotomy), and reflux + esophagitis (8 weeks after myotomy). All animals underwent stationary manometry of the esophagus with a four‐lumen perfused assembly after injection of 1‐, 2‐, and 3‐mL boluses of saline and acid into the proximal esophagus. Simultaneous pH monitoring allowed assessment of acid clearance. Wave features and clearance times after saline and acid were compared among groups.ResultsThere were minor changes in peristaltic activity of the esophagus after saline boluses in animals with reflux. Acid clearance time was prolonged, especially the time to re‐establish resting esophageal pH, in animals with esophagitis. These changes, which were volume‐dependent, were related to the loss of peristaltic organization of the esophageal waves. The esophageal wave frequency, amplitude, and duration were only slightly changed by the induction of reflux and by esophagitis.ConclusionsThe esophagus affected by acid reflux, with or without esophagitis, was capable of near‐normal motor responses after boluses of saline. Reflux impaired the peristaltic response to acid, and the effect was more pronounced when reflux and esophagitis were both present. The acid clearance time was also strikingly prolonged in the presence of reflux and esophagitis. The results suggest that long episodes of reflux seen on pH tracings from individuals with esophagitis might be secondary both to acid‐related motor dysfunction and large volumes of refluxate.

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Section: Discussionmentioning

confidence: 99%

Effect of Reflux and Esophagitis on Esophageal Volume and Acid Clearance in Piglets

Vicente,

da Rocha,

Perez‐Mies

et al. 2004

J. pediatr. gastroenterol. nutr.

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“…A further factor to be considered is whether to use single or multiple swallows [14], raising the question of radiation dose. 81mKr offers a useful alternative in this respect [15], but is subject to limited availability.…”

Section: Discussionmentioning

confidence: 99%

“…In a further study [14] these authors have compared the effects of single and multiple swallows using 8ImKr in dextrose as a tracer. Roland et al [15] have evaluated oesophageal transit in patients with minor peptic oesophagitis using a single bolus of 10 ml glucose/81mKr solution. Observations suggest that transit delay can occur with 99mTc sulphur colloid by adherence to inflamed oesophageal wall [16,17].…”

Section: Oesophageal Transitmentioning

confidence: 99%

Radiopharmaceuticals and the gastrointestinal tract

Frier

Perkins

1994

Eur J Nucl Med

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A review is presented of the design of radiolabelled test meals for the evaluation of gastrointestinal function, including oesophageal transit, gastro-oesophageal reflux, gastric emptying, enterogastric reflux and transit through the whole bowel. Descriptions of different systems are presented, together with validations of the procedures used. Published methods for assessment of oesophageal transit show a marked degree of consistency, whereas gastric emptying studies employ a wide range of both liquid and solid test meals. Recommendations are made concerning the optimal system for investigation of each part of the gastrointestinal tract, but whichever system is adopted, it is important to employ some validation procedures, and to establish normal ranges in the population under study.

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Oesophageal motility disorders in patients with psychiatric disease

Roland¹,

D’Haenen²,

Ham³

et al. 1996

Eur J Nucl Med

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Clinical and experimental observations indicate that the motility of the oesophagus may be affected by emotional stimuli. The aim of this study was to evaluate the incidence of oesophageal contractility impairment in patients suffering from a psychiatric disorder. Fifty-one patients admitted to the psychiatric department were submitted to an oesophageal transit study by means of krypton-81m. All patients with an abnormal oesophageal transit underwent manometry and endoscopy. The level of depression and anxiety was evaluated by the treating psychiatrist, using the Hamilton Depression and Anxiety Rating Scales. The oesophageal transit was abnormal in 13 patients. Two of these 13 patients refused manometric investigation. In ten of the 11 remaining patients, the manometry revealed functional motor abnormalities. Endoscopy, performed in all these ten patients, was normal. In conclusion, a high percentage of oesophageal contractility disturbances was found in psychiatric patients complaining of anxiety and/or depression. These abnormalities were detected by scintigraphy as well as by manometry. Owing to the normal endoscopic findings, these contraction abnormalities are likely to reflect a functional motor impairment.

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Evaluation of oesophageal transit in patients with minor peptic oesophagitis

Cited by 7 publications

References 0 publications

Effect of Reflux and Esophagitis on Esophageal Volume and Acid Clearance in Piglets

Effect of Reflux and Esophagitis on Esophageal Volume and Acid Clearance in Piglets

Radiopharmaceuticals and the gastrointestinal tract

Oesophageal motility disorders in patients with psychiatric disease

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