Evaluation of Novel Obesity- and Lipid-Related Indices as Predictors of Abnormal Glucose Tolerance in Chinese Women with Polycystic Ovary Syndrome

Abstract

Purpose We aimed to evaluate the performance of Chinese visceral adiposity index (CVAI), visceral adiposity index (VAI), lipid accumulation product (LAP), triglyceride glucose (TyG) as indices in screening abnormal glucose tolerance (AGT) in Chinese women with polycystic ovary syndrome (PCOS), using the oral glucose tolerance test (OGTT) as a reference test. In addition, we essentially compared the abilities of these indices with body mass index (BMI), waist circumference (WC), fasting plasma glucose (FPG). Materials and Methods All 1113 PCOS patients evaluated in this study underwent OGTTs. The 2-h post-oral glucose load (2 h-PG) level was used to categorize subjects into two groups: those having AGT or normal glucose tolerance (NGT) levels. Results A statistically significant positive correlation between levels of 2 h-PG and FPG, BMI, WC, LAP, VAI, CVAI, TyG, (P < 0.05), was observed. The strongest correlation was found between the levels of 2 h-PG and CVAI (r = 0.469). The CVAI provided the highest area under the receiver-operating characteristic curve (AUC) for AGT, followed by LAP, BMI, TyG, VAI, WC, and FPG. The CVAI of 32.61 (with AUC: 0.758, sensitivity: 73.4%, specificity: 69.9%) was found to be the cut-off point for AGT in Chinese women with PCOS. Conclusions The CVAI may be used as a screening indicator of AGT in Chinese women with PCOS when there is no time or possibility to perform an OGTT.

Selected Organ and Endocrine Complications According to BMI and the Metabolic Category of Obesity: A Single Endocrine Center Study

“…Interestingly, we also managed to distinguish the subgroup defined as pre-MetS. Thus far, the literature concerning the pre-MetS subgroup has been rather scarce, and the previous studies have focused on specific subgroups, such as PCOS, and have mainly been conducted in Asia or South America [ 22 , 23 , 24 , 25 ]. The inherent difficulty has been related to the heterogeneous nature of the group, as it has been characterized with a significantly higher HOMA-IR and TG in comparison to MHO, and with significantly lower WC and LDL and GGTP when compared to MetS.…”

What is the best anthropometry index to evaluate the risk of metabolic abnormalities in Chinese adults?

“…These measurements can accurately and comprehensively quantify the mass and distribution of fat and muscle. In a series of studies, percent body fat and fat mass index were found to be more valuable in predicting metabolic abnormalities than traditional measurements such as BMI and WC 12,13 . In addition, images measured with water‐fat magnetic resonance imaging, dual‐energy X‐ray absorptiometry, and ultrasound can also reflect whole‐body composition in a detailed and intuitive fashion; however, these approaches are not suitable for routine detection because of their high cost, complexity, and radioactivity 14 …”