2017
DOI: 10.1159/000481832
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Evaluation of Novel Anticaries Adhesive in a Secondary Caries Animal Model

Abstract: (1) secondary caries was successfully produced in rats; (2) there was a correlation between the modified Keyes scoring method and micro-CT in the evaluation of the secondary caries; (3) the adhesive containing DMADDM significantly reduced both LD and ML (according to micro-CT), and also lowered the scores (based on the modified Keyes scoring method). This suggests that the novel DMADDM adhesive could perform an anticaries function in vivo via the secondary caries animal model which was also developed and testi… Show more

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Cited by 30 publications
(32 citation statements)
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“…Meanwhile, the changed morphology and increased roughness can enhance the initial bacterial attachment and oral biofilm formation [ 17 ]. To demonstrate the actual effects on biofilm formation of dental material in a pragmatic way, the study models evolved consistently, from the previous water aging model to a biological aging model, from a primary caries animal model to a secondary caries animal model, and from in vitro to the in situ model used nowadays [ 73 , 74 , 75 ].…”
Section: Chemical Characteristics Of Dental Materialsmentioning
confidence: 99%
“…Meanwhile, the changed morphology and increased roughness can enhance the initial bacterial attachment and oral biofilm formation [ 17 ]. To demonstrate the actual effects on biofilm formation of dental material in a pragmatic way, the study models evolved consistently, from the previous water aging model to a biological aging model, from a primary caries animal model to a secondary caries animal model, and from in vitro to the in situ model used nowadays [ 73 , 74 , 75 ].…”
Section: Chemical Characteristics Of Dental Materialsmentioning
confidence: 99%
“…Specific-pathogen-free Spragur Dawley (SD) rats (Chengdu Dossy Experimental Animals Co., Ltd, China) were obtained at the age of three weeks and randomly assigned into three groups of five animals. All rats were provided with ampicillin (1 g/kg) in their drinking water for the first three days and then normal sterile water for another day to elute the antibiotic [29]. Then, the of S. mutans UA159 solution (10 9 CFU/mL, 0.3 mL) or the mutant strains were inoculated for three consecutive days.…”
Section: Rat Model Of Dental Cariesmentioning
confidence: 99%
“…37,38 The basic components of the adhesive system are: conditioning agent, primer and adhesive, in addition to photo initiators, polymerization inhibitors, and inorganic fillers. 33 They can also be modified with antimicrobial agents, [1][2][3][4][5][6][7][8][9][10][11][12][15][16][17][18][19][20]22,24,26,[28][29][30][31][39][40][41][42][43][44] mineralizing agents, 2,3,16,22,26,30,45 protein repellent, 2 inhibitors of metalloproteinases, 6,46,47 and even inti-inflammatory agents. 5 The understanding of the function of each system component and their careful use, respecting their indications, will be essential for adhesion success.…”
Section: Reviewmentioning
confidence: 99%
“…Secondary caries leads to restoration failure. [1][2][3][4][5][6][7][8][9][10] In the oral environment, the restorative composite u ndergoe s poly mer i zat ion sh r i n k age, 9,11-1 4 receives masticatory loads, 10,15 and accumulates biofilm; 8,16 being, therefore, susceptible to marginal failure, 10,12,17,18 adhesive interface degradation, 6,8,10,15,17 and micro-infiltration. 1,10,13,15,19 Likewise, residual bacteria may remain after cavity preparation, thus inducing the formation of recurrent caries.…”
Section: Introductionmentioning
confidence: 99%