Evaluation of non-HDL-c and total cholesterol: HDL-c Ratio as Cumulative Marker of Cardiovascular Risk in Diabetes Mellitus

Aryal, Madhukar; Poudel, Amrit; Satyal, Biswas; Gyawali, Prabin; Pokheral, Babu Ram; Raut, Binay Kumar; Adhikari, Ramesh; Koju, Rajendra

doi:10.3126/kumj.v8i4.6239

Cited by 17 publications

(16 citation statements)

References 40 publications

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“…The activities of TC and non-HDL-C were found to correlate with the risk of atherogenesis and, therefore, it was suggested that non-HDL-C could be used as an alternate marker to assess the risk of CVD [28].…”

Section: Discussionmentioning

confidence: 99%

Atherogenesis in Psoriasis: Evaluation of the Serum Activities of Non-high-density Lipoprotein Cholesterol and Other Lipids Among Newly Diagnosed Psoriasis Patients

Thungaturthi¹,

Vadakedath²,

Pavuluri³

et al. 2019

Cureus

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Introduction Psoriasis is a chronic inflammatory skin disorder which commonly affects people aged between 15-25 years with a 2-3 % prevalence rate throughout the world. Psoriasis is a systemic inflammatory disease associated with severe co-morbidities that include cardiovascular risk. Although changes in the atherogenic lipids among psoriasis patients is already documented, very little is known about their role in atherogenesis among the new onset cases of psoriasis. Hence, this study is undertaken to assess the activities of non-high-density lipoprotein cholesterol (non-HDL-C) and other lipids among newly diagnosed psoriasis patients. Methods The study included 25 new onset cases of psoriasis patients aged between 20-60 years (mean age 38.2 years) attending the Dermatology outpatient department (OPD) of the Chalmeda Anandrao Institute of Medical Sciences (CAIMS), Karimnagar, Telangana, India, a tertiary care teaching hospital. An equal number of healthy individuals were included as controls. Blood was collected from all the subjects included in the study and was analyzed for various lipid parameters that included total cholesterol (TC), HDL-C, and triglycerides. The non-HDL-C and low-density lipoprotein cholesterol (LDL-C) were later calculated manually by using the standard formulae. The data were tabulated using Microsoft Excel and was analyzed for their statistical significance using the Student t-test. Results The results demonstrated a statistically significant difference in the lipid parameters between the cases and controls. Among the parameters measured, the pro-atherogenic lipids including the LDL-C and non-HDL-C activities among the cases (LDL-C 171.46±17.13, p=0.0002; non-HDL-C 213.27±20.17, p ≤ 0.0001) and controls (LDL-C 91.04±11.41, p=0.0002; Non-HDL-C 119.0± 12.28, p ≤ 0.0001) were found to be statistically significant. The ratios of non-HDL-C to HDL-C and total cholesterol to HDL-C both among the cases (7.10±0.1, 8.13±1.2) and control groups (3.05±0.30, 4.03±0.42) were also showing a statistically significant difference. Conclusion The results clearly demonstrate the significance of the evaluation of lipids among newly diagnosed cases of psoriasis patients. The activities of different lipoproteins including the non-HDL-C and LDL-C revealed an increase among the psoriasis patients. The ratios of non-HDL-C to HDL-C and TC to HDL-C also showed significant variability. Further, to establish their clinical utility in the development of cardiovascular disease (CVD), and to manage appropriately, a regular follow-up of such parameters both before and after initiation of treatment is required.

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Section: Discussionmentioning

confidence: 99%

Atherogenesis in Psoriasis: Evaluation of the Serum Activities of Non-high-density Lipoprotein Cholesterol and Other Lipids Among Newly Diagnosed Psoriasis Patients

Thungaturthi¹,

Vadakedath²,

Pavuluri³

et al. 2019

Cureus

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“…The calculation of the levels of cardiac risk (CR) was carried out by the formula: CR=TC/HDL-c [9]. The coefficient of atherogenicity (CA) was calculated by the following formula: CA=(TC-HDL-c)/HDL-c [10] (referent values -2,2-3,5). Lactate concentration was determined using diagnostic set for determination of its concentration (referent value is 0,5-2,2 mmol/l) and LDH that was also determined using diagnostic set for LDH (LD) by optimized method, elaborated taking into account the recommendations of German Association of clinical chemistry (DGKC) (referent values 225-450 U/l) after correspondent calibration of automatic analyzer ACCENT-200 II GEN. Statistical processing of data was carried out using the package of applied programs Microsoft Office Excel 2010 and StatSoft Statistica 6.1 [11].…”

Section: Methodsmentioning

confidence: 99%

Atherogenic Parameters and Cardiac Indices in Prognostication of Development of Pre-Eclampsia and Its Cardiometabolic Consequences

Aksonova

Ventskovskaya

Yuzvenko

2016

EUREKA: Health Sciences

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Aim of the work. The study of interconnection between atherogenic parameters of the blood serum and cardiac indices during pregnancy with the risk of pre-eclampsia development and prognostication of remote cardio-vascular and/or metabolic pathology among pregnant. Materials and methods. The indices of lipid metabolism in the blood serum of 267 pregnant women were studied using diagnostic sets of reagents. The blood sampling was carried out in II (16-24 gestational weeks) trimester. The general cholesterol (GC) and triglycerides (TG) were determined by colorimetric and enzymatic method; high-density lipoproteins-HDL-by homogenous method of direct determination of HDL-cholesterol concentration in the blood serum without preliminary processing and centrifugation, low-density lipoproteins-LDL-by the direct method. VLDL concentration was calculated by Friedewald formula: LDL=TG/2,2. For evaluation of GC-VLDL concentration TG/2,2 parameter is used, if TG concentration is expressed in mmol/l (or TG/5, if concentration is expressed in mg/100 ml). Cardiac indices were calculated taking into account the lipid parameters according to the correspondent mathematical formulas. Lactate and LDH concentrations were determined by optimized method using diagnostic reagents. Lactate concentration was determined at the use of diagnostic set for determination of lactate concentration, and DLH was also determined by diagnostic set for determination of LDH (DL) activity by optimized method, elaborated taking into account the recommendations of German Association of clinical chemistry (DGKC) after correspondent calibration of automatic analyzer ACCENT-200 II GEN. Depending on the development of clinical presentation of PE 43 women were divided in groups with light and middle severity of course of this pathology. Results and discussion. Among the women with PE development was observed the essential changes in II trimester in the aspect of atherogenic parameters and cardiac indices mainly at the expense of progressing increase of TG in the blood serum (mmol/l: I group-1,73±0,14, II group-1,86±0,18 comparing with III control group-1,51±0,06. The gradual growth of cardiac (atherogenic) indices-AIP, CR and CА and connection between AIP and the levels of maternal serumal TG and arterial pressure were observed in women with PE development at the absence of such connection among the women of control group (p<0,05). LDH level grew with the progressing of PE severity: for the women of I group LDH level was-389±1,6 U/l at 778±0,25 in women of II group and 265±0,19 in the control group (p <0,05).

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“…The ratio of total cholesterol (TC) to high-density lipoprotein (HDL) is an established predictor of coronary heart disease and a good indicator of abnormal cholesterol metabolism. 78 The TC to HDL ratio is a simple, non-invasive and cost effective means of predicting the presence and extent of coronary atherosclerosis and a marker of cardiovascular risk (coronary artery disease, ischemic stroke) 79,80 and insulin resistance. 81 The risk for cardiac events is significantly higher when the TC:HDL ratio is 5 mmol/L or greater.…”

Section: Additional Notesmentioning

confidence: 99%

Monitoring chronic diseases in Canada: the Chronic Disease Indicator Framework

Betancourt

Roberts

Bennett

et al. 2014

Chronic Dis Inj Can

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Chronic Diseases and Injuries in Canada (CDIC) is a quarterly scientifi c journal focussing on current evidence relevant to the control and prevention of chronic (i.e. noncommunicable) diseases and injuries in Canada. Since 1980 the journal has published a unique blend of peer-reviewed feature articles by authors from the public and private sectors and which may include research from such fi elds as epidemiology, public/community health, biostatistics, the behavioural sciences, and health services or economics. Only feature articles are peer reviewed. Authors retain responsibility for the content of their articles; the opinions expressed are not necessarily those of the CDIC editorial committee nor of the Public Health Agency of Canada. Chronic Diseases and Injuries in

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Evaluation of non-HDL-c and total cholesterol: HDL-c Ratio as Cumulative Marker of Cardiovascular Risk in Diabetes Mellitus

Cited by 17 publications

References 40 publications

Atherogenesis in Psoriasis: Evaluation of the Serum Activities of Non-high-density Lipoprotein Cholesterol and Other Lipids Among Newly Diagnosed Psoriasis Patients

Atherogenesis in Psoriasis: Evaluation of the Serum Activities of Non-high-density Lipoprotein Cholesterol and Other Lipids Among Newly Diagnosed Psoriasis Patients

Atherogenic Parameters and Cardiac Indices in Prognostication of Development of Pre-Eclampsia and Its Cardiometabolic Consequences

Monitoring chronic diseases in Canada: the Chronic Disease Indicator Framework

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