Evaluation of nicotine patch in pain control of patients undergoing laparoscopic cholecystectomy

Filho, Euclides Dias Martins; Vasconcelos, César Freire de Melo; Santa‐Cruz, Fernando; Pereira, Adriano Da Fonseca; Ferraz, Álvaro Antônio Bandeira

doi:10.1590/0100-6991e-20181756

Cited by 5 publications

(1 citation statement)

References 26 publications

(32 reference statements)

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“…Moreover, in the study by Turan et al, intraoperative use of nicotine patch and opioids did not reduce the amount of postoperative pain after gynecological surgery. 32 Nevertheless, Martins et al 33 analyzed 17 patients under laparoscopic cholecystectomy and observed that despite the low pain score for the nicotine group at 24 hours, nicotine was not effective in controlling pain at the time intervals of the study. In addition, it has been shown in various studies that nicotine can cause hypoxia in tissues as a vasoconstrictor and also by increasing the concentration of calcium ions.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Nicotine Patch on Reducing Nausea, Vomiting, and Pain Following Laparoscopic Cholecystectomy: A Randomized Clinical Trial

Seyedsadeghi,

Arabzadeh,

Entezariasl

et al. 2023

Addict Health

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Background: The effect of nicotine on nausea, vomiting, and postoperative pain has been investigated in studies on animals and humans. This study aimed to evaluate the effect of nicotine patch on decreasing nausea, vomiting, and pain in laparoscopic cholecystectomy. Methods: The study sample consisted of 100 non-smoking patients undergoing laparoscopic cholecystectomy under general anesthesia in a triple-blind clinical trial. One hour after the start of surgery, patients were randomly assigned to receive 17.5-mg nicotine or placebo patches. The patches located on the right arm were left for 24 hours. The visual analogue scale (VAS) for pain and N/V score for the severity of nausea and vomiting were measured at intervals of 0, 6, 12, and 24 hours. Findings: The results showed there was no statistically significant difference between the groups in terms of pain intensity as well as nausea and vomiting at different time periods after surgery (P>0.05). A total of 36 patients in the nicotine group and 24 patients in the placebo group received meperidine. There was also no statistically significant difference between the two groups in terms of analgesics (P=0.096) and antiemetics (P=0.1). Moreover, the frequency of severe nausea and vomiting during the study in the nicotine group was higher than in the placebo group (4 vs. 1) but this difference was not statistically significant (P>0.05). Conclusion: Receiving a 17.5-mg nicotine patch had a similar effect to receiving placebo in controlling postoperative pain, nausea, and vomiting in non-smokers. Nicotine use had no effect on reducing analgesia.

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Section: Discussionmentioning

confidence: 99%

The Effect of Nicotine Patch on Reducing Nausea, Vomiting, and Pain Following Laparoscopic Cholecystectomy: A Randomized Clinical Trial

Seyedsadeghi,

Arabzadeh,

Entezariasl

et al. 2023

Addict Health

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Analgesic potential of transdermal nicotine patch in surgery: a systematic review and meta-analysis of randomised placebo-controlled trials

Barbirato

Vasconcelos

Moraes

et al. 2023

Eur J Clin Pharmacol

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Effectiveness of nicotine patch for the control of pain, oedema, and trismus following third molar surgery: a randomized clinical trial

Landim

Filho

Nascimento

et al. 2020

International Journal of Oral and Maxillofacial Surgery

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Evaluation of nicotine patch in pain control of patients undergoing laparoscopic cholecystectomy

Abstract: although pain levels were lower for nicotine within 24 hours, the action of nicotine and the need for rescue opioids in pain control were not statistically significant between the groups and at the time intervals studied. There was no clinical repercussion in the hemodynamic parameters.

Cited by 5 publications

References 26 publications

The Effect of Nicotine Patch on Reducing Nausea, Vomiting, and Pain Following Laparoscopic Cholecystectomy: A Randomized Clinical Trial

The Effect of Nicotine Patch on Reducing Nausea, Vomiting, and Pain Following Laparoscopic Cholecystectomy: A Randomized Clinical Trial

Analgesic potential of transdermal nicotine patch in surgery: a systematic review and meta-analysis of randomised placebo-controlled trials

Effectiveness of nicotine patch for the control of pain, oedema, and trismus following third molar surgery: a randomized clinical trial

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