Effectiveness of nicotine patch for the control of pain, oedema, and trismus following third molar surgery: a randomized clinical trial

Landim, Fabrício Souza; Filho, José Rodrigues Laureano; Nascimento, Jéssica Maria Torres De Sousa; Vasconcelos, Belmiro Cavalcanti do Egito

doi:10.1016/j.ijom.2019.08.013

Cited by 13 publications

(9 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The number of pain medications used was inferior, and patient satisfaction was significantly higher, even with some nausea in the nicotine patch group. Nicotine patches were effective in controlling postoperative third molar pain, edema, and trismos (Landim et al, 2020).…”

Section: Resultsmentioning

confidence: 98%

“…Other articles have also evaluated alternative drugs with significant success in controlling pain in the postoperative period of the third molars, including using patches containing 14 mg of nicotine (Landim et al, 2020), using 0.8% hyaluronic acid in gel (Yilmaz et al 2017), and using mouthwash green tea (Eshghpour et al, 2013). While these are unique articles that rated these drugs, they are well science-based and have a minimal risk of bias.…”

Section: Other Drugsmentioning

confidence: 99%

See 1 more Smart Citation

Non-conventional therapies for analgesia

Pellizoni

Faccio

Jodas

et al. 2021

RSD

View full text Add to dashboard Cite

Purpose: Third molar surgery is a quite common procedure. Some patients experience pain associated with this situation. The aim of this article aims to discuss non-conventional therapies for the management of postoperative pain associated with third molar surgery. Methods: An extensive literature search was conducted with the keywords “third molar” + “pain” and all articles that excluded already established drugs as analgesics, anti-inflammatories, or therapies such as laser therapy and ozone therapy whereas non-conventional drugs and therapies were retained. Results: The article rated bromelain, honey, hyaluronic acid, nicotine patches, Kinesio tape, TENS, anticonvulsants, curcumin, and melatonin. Some therapies are efficient and safe, while others have not shown promising results. Conclusions: Bromelain and Kinesio tape are considered the most effective non-conventional therapies for controlling postoperative pain, and even with few studies on them, they are therapies with promising results.

show abstract

Section: Resultsmentioning

confidence: 98%

Section: Other Drugsmentioning

confidence: 99%

Non-conventional therapies for analgesia

Pellizoni

Faccio

Jodas

et al. 2021

RSD

View full text Add to dashboard Cite

show abstract

“…Facial swelling will be measured using a metric tape and standard reference points. 6 The following reference points will be used for the measurement:…”

Section: Discussionmentioning

confidence: 99%

Comparison of the efficacy of aescin and diclofenac sodium in the management of postoperative sequelae and their effect on salivary Prostaglandin E2 and serum C–reactive protein levels after surgical removal of impacted mandibular third molar: a randomized, double-blind, controlled clinical trial.

Singhai,

Kambala,

Bhola

2024

F1000Res

View full text Add to dashboard Cite

Introduction Surgical removal of an impacted third molar is one of the most common oral surgical procedures performed in dental offices. The postoperative phase is often associated with severe inflammation. Non-steroidal anti-inflammatory drugs (NSAIDs) are usually prescribed to manage postoperative discomfort. NSAIDs have been associated with gastrointestinal bleeding, renal function disturbances, and platelet count reductions. Thus, the present study demonstrates the utility of aescin in managing postoperative discomfort after the surgical removal of impacted mandibular third molars. This study aimed to correlate salivary PGE2 levels and serum C-reactive protein levels with subjective and objective symptoms after surgical extraction of the mandibular third molar and their relationship with drug therapy. Methods The planned study is a single-center, double-blind, randomized, parallel, prospective clinical trial. Each patient will be prescribed either diclofenac sodium 150 mg/day or aescin (escin) 120 mg/day to be taken orally in divided doses for five days after surgically removing the impacted mandibular third molar. Pain will be assessed using a visual analog scale. Facial swelling and mouth opening will be recorded using a metric scale with standardized reference points. ELISA (enzyme-linked immunosorbent assay (ELISA) will be employed to measure salivary Prostaglandin E2 and serum C–reactive protein levels. All parameters will be recorded preoperatively (T0) on the second postoperative day (T1) and fifth postoperative day (T2). Conclusion The proposed study is expected to show a favorable response to the administration of aescin for the management of postoperative discomfort compared to diclofenac sodium after third molar surgery. The proposed study is expected to positively manipulate the levels of salivary Prostaglandin E2 and serum C–reactive protein, which are reliable inflammatory markers. The outcome of this study may provide an efficacious and safe alternative to conventional nonsteroidal anti-inflammatory drugs for managing postoperative discomfort following third molar surgery.

show abstract

“…During the post-operative period, the participants who had received the nicotine patches were administered significantly fewer analgesic tablets compared to the placebo control group (mean 2.35 vs. 4.35, respectively; p = 0.026) and rated their recovery as more satisfactory than those who received the placebo. Swelling was also reduced during the first 72 h post-surgery, indicating an anti-inflammatory effect in the patients who received the nicotine patch (53). The authors suggest that the nicotine patch is the most effective mode of administration as peak plasma concentration occurs at around the same time as peak post-operative pain and initiation of the inflammatory response.…”

Section: Pain and Infectionmentioning

confidence: 93%

Nicotine and Inflammatory Disease in Humans: A Systematic Review

Price

Thompson

Martínez

2022

Contributions to Tobacco &Amp; Nicotine Research

View full text Add to dashboard Cite

Summary Introduction Previous studies have shown that nicotine interacts in inflammatory pathways and may have both pro- and anti-inflammatory actions. The aim of this study was to carry out a systematic review of publications investigating the inflammatory effects of nicotine in models of human disease. Methods The Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) checklists were followed during the design and implementation of this study. Searches were carried out across PubMed, Science Direct, and the Cochrane Library. Articles were included if they were published in English, in peer-reviewed journals, reported an effect of nicotine in the treatment of a clinical condition, experimental studies or clinical trials which investigated an effect of nicotine administration in patients with a clinical condition or epidemiological studies which investigated an effect of nicotine administration in patients with a clinical condition. Results Thirty-eight studies were identified and categorized into disease areas before systematic review. Nineteen studies were related to digestive diseases (primarily Crohn’s disease and ulcerative colitis), six to atherosclerosis, five to skin and healing, four to pain and infection, three to pulmonary sarcoidosis, and three to multiple sclerosis (one study reported data on three disease areas). Risk of bias assessment was not carried out, but the general quality of the studies was low, mostly offering preliminary data in small numbers of participants. No consistent effects of nicotine treatment (primarily through use of transdermal nicotine patches or nicotine chewing gums) were reported across any of the disease models. Conclusion No reliable evidence of a pro- or anti-inflammatory effect of nicotine was observed in patients with any of the diseases included in this study.

show abstract

Effectiveness of nicotine patch for the control of pain, oedema, and trismus following third molar surgery: a randomized clinical trial

Cited by 13 publications

References 25 publications

Non-conventional therapies for analgesia

Non-conventional therapies for analgesia

Comparison of the efficacy of aescin and diclofenac sodium in the management of postoperative sequelae and their effect on salivary Prostaglandin E2 and serum C–reactive protein levels after surgical removal of impacted mandibular third molar: a randomized, double-blind, controlled clinical trial.

Nicotine and Inflammatory Disease in Humans: A Systematic Review

Contact Info

Product

Resources

About