Evaluation of newly isolated probiotics in the protection against experimental intestinal trichinellosis

Temsahy, Mona M. El; Ibrahim, Iman; Mossallam, Shereen F.; Mahrous, Hoda; Bary, Amany Abdel; Salam, Sara Ahmed Abdel

doi:10.1016/j.vetpar.2015.08.029

Cited by 35 publications

(39 citation statements)

References 27 publications

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“…A suspension of Lactobacillus acidohilus, L. delbruckii revealed potential leverage against canine ancylostomiasis (16). Researchers observed that L. casei has anthelminthic 75-100% prophylactic effect, and Lactobacillus plantarum P164 (17) revealed 90% protection against T. spiralis, ensured that these strains are safe as protective and curative probiotics (17,23,35,36), A suspension for different probiotics revealed an increased worthy preservation 90% against Anchylostoma caninum infection in dogs (16), otherwise, Bifidobacterium animalis 04450B dose 9*10 2 CFU showed less protection 33% decrease of adult worms and 21% decrease of egg production Strongyloids venesuelensis infection in mice (37). First of all, we used orally administration with probiotic bacteria in experimental animals, but we didn´t see significant or obvious results that ensure the effect of bacteria as stimulative, when compared with the control group, so we used intraperitoneally injection because larval stages (hydatid cysts) are extraintestinal, so that the effect of intraperitoneal injection was very effectively obvious than oral administration.…”

Section: Discussionmentioning

confidence: 99%

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Effect of probiotic acidophilus plus against infection with secondary hydatid disease in BALB /c mice

Yousif¹,

Ali²

2020

IJVS

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The current study investigated the effect of acidophilus plus probiotic in the immune activities in mice to infestation with the cystic echinococcosis. Two dilutions of the probiotic bacteria 9*10 6 /0.1 ml, 30*10 3 /0.1 ml CFU were used, by intraperitoneally injection in the experimental animals, pre and post infections with protoscoleces of Echinococcus granulosus. Before infection remedy comprised injection by acidophilus plus twice with 72 hours interval, on the seventh day, animals were injected with protoscoleces intraperitoneally, after infection remedy implicated injection of animals with protoscoleces of Echinococcus protoscoleces first, next to 72 hours, probiotics were inoculated intraperitoneally. Many criteria were taken into consideration including, numbers, weights, diameters and percentage reduction of hydatid cysts of treated mice in contrast to the animals infested with only. The study showed a decline in cysts including their diameter, weighting, digit, accompanied by increasing the percentage reduction of hydatid cysts in treated mice, the highest percentage reduction was 98.03%, at both dilutions, 6 months post infection, and the minimum cysts number was 0.8 in comparison with the control group 39.4, with significant difference, in the same experiment. The minimum cysts weight was 0.0104 gm, 6 months post infection at the dilution 9*10 6 /0.1 ml CFU, compared with the control group 0.442 gm. The smallest cysts diameter was 0.057 mm in comparison with the control group 0.882 mm at dilution 9*10 6 /0.1 ml CFU, 6 months post infection. Acidophilus plus it may well be deduced that probiotic bacteria can be used as medicinal and remedial method against infection with hydatidosis.

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Section: Discussionmentioning

confidence: 99%

“…Elevation of white blood cells has been observed (16). Researchers found that L. casei is the firstly strain among other strains of Lactobacilli has anthelmintic effect of about 75-100% prevention, another strain is L. plantarum with efficacy of 90% against Trichenilla spiralis (17).…”

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confidence: 99%

Effect of probiotic acidophilus plus against infection with secondary hydatid disease in BALB /c mice

Yousif¹,

Ali²

2020

IJVS

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“…Administration of probiotics promoted successful establishment of H. polygyrus in mice, via reduction of Th2 cytokines such as IL-4 a and IL-13 and an increase in regulatory TCD4+ cells [55]. In contrast, resistance to T. spiralis was enhanced by promoting Th2 responses after oral administration of Lactobacillus casei [56]. In the case of IL-25, several studies support that its intestinal production is regulated by resident microbiota showing that, in general, dysbacteriosis upregulates IL-25 expression [57].…”

Section: Discussionmentioning

confidence: 99%

Interleukin-25-mediated resistance against intestinal trematodes does not depend on the generation of Th2 responses

Álvarez-Izquierdo

Pérez-Crespo

Esteban

et al. 2020

Preprint

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Interleukin-25 (IL-25) plays a major role in resistance against intestinal helminth infections as initiator of protective Th2 responses. However, recent studies have challenged the contribution of this cytokine in both the polarization of the response towards a Th2 phenotype and the parasite rejection. We have used the experimental model Echinostoma caproni-ICR mice to investigate the participation of this cytokine in resistance to intestinal helminths. ICR mice are characterized by their inability to respond with IL-25 production in primary infections with E. caproni, causing susceptibility associated with a Th1 response. However, mice are refractory to infection in presence of IL-25 in relation to a type 2 phenotype. Herein, we show that dynamics of resident microbiota appears to be crucial in IL-25 production. Moreover, IL-25 seems to play a pivotal role in the polarization to Th2 in primary responses, but also appears to participate in the generation of memory mechanisms making unnecessary the participation of IL-25 in memory responses for the development of Th2 milieu. However, resistance to E. caproni infection does not depend on the generation of a Th2 phenotype, but exclusively depends on the presence of IL-25, operating autonomously from the type 2 response in the generation of resistance.

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“…The highest protection was elicited by L. plantarum, against adult (69.02%) and ML (87.92%). Interestingly, the authors demonstrated an amelioration of inflammation and damage in the intestine of T. spiralis-infected mice inoculated with L. plantarum with respect to non-treated-infected animals [72]. So far, the use of probiotics is considered as a new tool for trichinellosis control.…”

Section: Probiotics In Protection Against T Spiralis Infectionmentioning

confidence: 99%

Vaccination against Trichinella spiralis: Potential, Limitations and Future Directions

Andrade-Becerra¹,

Pompa-Mera²,

MaríaRibas-Aparicio³

et al. 2017

Natural Remedies in the Fight Against Parasites

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Trichinellosis is a food-borne parasitic disease caused by round worms of the genus Trichinella. The majority of human outbreaks are attributed to consumption of raw or undercooked pork meat contaminated with T. spiralis muscle larvae. A blockingtransmission vaccine against trichinellosis will allow preventing swine infection and will contribute to disease control. In this chapter, different vaccine candidates so far developed against T. spiralis, including first-, second-, and third-generation vaccines, are discussed. Most vaccine candidates are based on a unique antigen mainly from the muscle larva stage, inducing with some exceptions, partial protection although a mix Th1/Th2 immune response is elicited. Therefore, the need for identification of new antigens from different parasite stages focusing on infective intestinal larvae, adult, and newborn larvae stages as well as the evaluation of their protective capacity in pigs is presented. The design of multi-epitope vaccines and the use of adjuvants or immunomodulatory molecules capable to polarize the immune response to a Th2-type-protective response are discussed as imperative elements of modern vaccines. Plant-based vaccines and probiotics as excellent tools for vaccine development against T. spiralis are also presented as an attractive platform for veterinary vaccines.

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Evaluation of newly isolated probiotics in the protection against experimental intestinal trichinellosis

Cited by 35 publications

References 27 publications

Effect of probiotic acidophilus plus against infection with secondary hydatid disease in BALB /c mice

Effect of probiotic acidophilus plus against infection with secondary hydatid disease in BALB /c mice

Interleukin-25-mediated resistance against intestinal trematodes does not depend on the generation of Th2 responses

Vaccination against Trichinella spiralis: Potential, Limitations and Future Directions

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