Evaluation of new-generation serologic tests for the diagnosis of typhoid fever: data from a community-based surveillance in Calcutta, India

Dutta, Shanta; Sur, Dipika; Manna, Byomkesh; Sen, Bhaswati; Deb, Alok Kumar; Deen, Jacqueline; Wain, John; Seidlein, Lorenz von; Ochiai, R. Leon; Clemens, John D.; Bhattacharya, Sujit

doi:10.1016/j.diagmicrobio.2006.06.024

Cited by 77 publications

(67 citation statements)

References 16 publications

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“…In other studies performed in endemic regions of India, the overall sensitivity of the Widal test was 64.49% for the O antibody and 78.26% for the H antibody and is a commonly used test in resource poor settings [15]. In the present study if both O and H antibody titres were high (>1:160) irrespective of culture results, a presumptive diagnosis of typhoid was made, and the diagnosis was supported by clinical manifestations of the patient.…”

Section: Discussionmentioning

confidence: 69%

Dengue and Typhoid Co-infection– Study from a Government Hospital in North Delhi

Sharma

Arya

Jain

et al. 2014

JCDR

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Section: Discussionmentioning

confidence: 69%

Dengue and Typhoid Co-infection– Study from a Government Hospital in North Delhi

Sharma

Arya

Jain

et al. 2014

JCDR

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“…For our study, only the O antibody titre levels were diagnostic as few samples (22%) showed any significant rise in H antibody titres. In other studies performed in endemic regions of India [11], the overall sensitivity of the Widal test was 64.49% for the O antibody and 78.26% for the H antibody. Hence in the Indian study, the H antibody was regarded as more diagnostic, and this contrasts with our findings where O antibody titre levels were observed to be more predictive of typhoid.…”

Section: Challenges Of Diagnosis Of Typhoid Fever In Sub-saharan Africamentioning

confidence: 70%

Typhoid fever in sub-Saharan Africa: Challenges of diagnosis and management of infections

Kariuki

2008

J Infect Dev Ctries

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Typhoid fever, caused by Salmonella enterica serovar Typhi (S. Typhi), is a disease transmitted by the faecal-oral route. It continues to be a public health problem in many developing countries in sub-Saharan Africa. School-age children, especially those from resource-poor settings with inadequate water and sanitation systems, are disproportionately affected. It is estimated that a total of 400,000 cases occur annually in Africa, an incidence of 50 per 100,000 persons per year. Lack of effective diagnosis often leads to inappropriate treatment and management of these infections. Additionally, the emergence and spread of S. Typhi strains having multiple resistance to nearly all commonly available drugs in most developing countries has been a major challenge to health care systems, reducing the effective treatment options for the disease, increasing treatment costs and increasing the risk of complications and death. Although not much data from sub-Saharan Africa has been published, it seems clear that typhoid is common in Nigeria, Mali, Ethiopia and Kenya. Given the importance of information on disease incidence for targeting control measures, including improved sanitation and water supply, vaccination and assessing impact, priority should be given to strengthening surveillance systems for typhoid fever.

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“…The study found that during the acute stage of fever the result of tubex and typhidot were not better than the widal test [17]. Tubex TF was found to have low sensitivity in a study in China.…”

Section: Discussionmentioning

confidence: 99%

Comparative Evaluation of Tubex T F (Inhibition Magnetic Binding Immunoassay) for Typhoid Fever in Endemic Area

Khanna

Gill

2015

JCDR

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Evaluation of new-generation serologic tests for the diagnosis of typhoid fever: data from a community-based surveillance in Calcutta, India

Cited by 77 publications

References 16 publications

Dengue and Typhoid Co-infection– Study from a Government Hospital in North Delhi

Dengue and Typhoid Co-infection– Study from a Government Hospital in North Delhi

Typhoid fever in sub-Saharan Africa: Challenges of diagnosis and management of infections

Comparative Evaluation of Tubex T F (Inhibition Magnetic Binding Immunoassay) for Typhoid Fever in Endemic Area

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