Evaluation of neutrophil to lymphocyte ratio as a predicted marker for the assessment of severe Coronavirus Disease-19 patients under a resource-constrained setting

Islam, Sabrina; Rahman, Mahbubur; Hasan, Mohammad Nayeem

doi:10.1016/j.ijid.2021.12.112

Cited by 2 publications

(2 citation statements)

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“…We found the association with only neutrophils rather than lymphocytes. NLR is also able to distinguish severe cases from mild-moderate cases of COVID-19 20 . The majority of the participants in our research had mild symptoms of COVID-19, and 70% of the obese patients had mild cases as well.…”

Section: Discussionmentioning

confidence: 99%

The Relationship Between BMI And Neutrophil/Lymphocyte Ratio in Non-critical Hospitalized Patients With Coronavirus Disease 2019

Morshed¹,

Banu²,

Sultana³

et al. 2022

Bangla J Med

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Background: People with obesity may be adversely affected by Coronavirusdisease 2019 (COVID-19). The objective of the study was to assess the clinical and biochemical characteristics of non-critical hospitalized patients of COVID-19 with obesity. Methods: This cross-sectional observational study was done among 88 non-critical hospitalized patients of COVID-19 [age: 50.0 (33.50-60.0) years, median (IQR); m/f: 36/52). The severity of COVID- 19 at diagnosis was determined by WHO interim guidance on COVID-19, 2000, and obesity was defined by a body mass index of 25 kg/m2. Clinical and biochemical information at diagnosis were collected in a data sheet. Results: Around 34% of the patients had obesity. Baseline characteristics and clinical features were statistically similar between obese and non-obese patients (NS for all). Among biochemical features, only total leukocytes (p=0.007), absolute neutrophils count (p=0.001), and neutrophils/ lymphocytes ratio (p=0.002) were significantly lower in obese patients than non-obese patients. Body mass index (BMI) had significant negative correlations with total leukocytes (r=-0.318, p=0.005), absolute neutrophil count (r=-370, p=0.001) and neutrophils/lymphocytes ratio (r=-0.349, p=0.002) in the study population. Conclusion: BMI had inverse associations with total leukocytes, absolute neutrophil count, and neutrophil/lymphocyte ratio among non-critical hospitalized patients with COVID-19. Bangladesh J Medicine 2022; 33: 36-42

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Section: Discussionmentioning

confidence: 99%

The Relationship Between BMI And Neutrophil/Lymphocyte Ratio in Non-critical Hospitalized Patients With Coronavirus Disease 2019

Morshed¹,

Banu²,

Sultana³

et al. 2022

Bangla J Med

View full text Add to dashboard Cite

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“…Although several studies also reported the predictive prognostic value of NLR in ARDS patients [22][23][24], NLR only reflects the inflammatory and immune status in these patients. In fact, the occurrence and development of ARDS is more complex, which is related to the crosstalk between systemic inflammatory response, abnormal immune regulation, and coagulation dysfunction [25].…”

Section: Introductionmentioning

confidence: 99%

Prognostic value of neutrophils to lymphocytes and platelets ratio for 28-day mortality in patients with acute respiratory distress syndrome: a retrospective study

et al. 2022

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Background Acute respiratory distress syndrome (ARDS) is a rapidly progressive and fatal respiratory failure disease that often occurs in critically ill patients. Since ARDS is associated with immune dysregulation and coagulation abnormalities, it is necessary to identify an appropriate predictor that can accurately predict ARDS mortality based on its pathophysiology. Therefore, this study aimed to evaluate the clinical value of neutrophils to lymphocytes and platelets ratio (N/LPR) in predicting 28-day mortality in ARDS patients. Methods From July 2018 to October 2021, the medical records of ARDS patients were retrospective reviewed. Neutrophil count, lymphocyte count, and platelet count were collected, and the neutrophil-to-lymphocyte ratio (NLR) and N/LPR were calculated. Multivariate logistic regression analyses were performed to identify independent predictors of 28-day mortality in ARDS. Receiver operating characteristic (ROC) curve with the area under curve (AUC) was used to evaluate optimal cut-off values for 28-day mortality in ARDS. Kaplan–Meier analysis was used to estimate the 28-day survival probabilities stratified by optimal cut-off values of N/LPR and NLR. Results A total of 136 ARDS patients were included in this study and were further divided into survivors (n = 69) and non-survivors (n = 67) groups according to their survival status on day 28. There were no significant differences between the two groups in age, sex, history of smoking and drinking, comorbidities, and reasons of admission (P > 0.05). Non-survivors had significantly higher neutrophil counts, NLR and N/LPR and had significantly lower platelet counts than survivors (P < 0.05). Multivariate regression analysis revealed that N/LPR, NLR and platelet counts were independent predictors for 28-day mortality in ARDS (P < 0.05). The ROC analyses showed that N/LPR with optimal cut-off value of 10.57 (sensitivity: 74.6%; specificity: 72.5%) is a more reliable predictor for 28-day mortality in ARDS than NLR and platelet count (AUC: 0.785 vs. 0.679 vs. 0.326). Further subgroup analysis confirmed that ARDS patients with N/LPR < 10.57 had significantly lower 28-day mortality than patients with N/LPR ≥ 10.57 (P < 0.001). Kaplan–Meier analysis also confirmed that ARDS patients with N/LPR < 10.57 had significantly longer survival. Conclusion N/LPR is an independent risk factor associated with 28-day mortality in ARDS patients and shows better performance in predicting mortality rate than NLR.

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Evaluation of neutrophil to lymphocyte ratio as a predicted marker for the assessment of severe Coronavirus Disease-19 patients under a resource-constrained setting

Cited by 2 publications

References 0 publications

The Relationship Between BMI And Neutrophil/Lymphocyte Ratio in Non-critical Hospitalized Patients With Coronavirus Disease 2019

The Relationship Between BMI And Neutrophil/Lymphocyte Ratio in Non-critical Hospitalized Patients With Coronavirus Disease 2019

Prognostic value of neutrophils to lymphocytes and platelets ratio for 28-day mortality in patients with acute respiratory distress syndrome: a retrospective study

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