Background: KMC is a safe, low cost and effective method of caring for low birthweight (LBW) babies to reduce neonatal morbidity and mortality.
Objectives:To assess the effect of KMC on LBW babies when compared with conventional method of care.Methods: This randomized controlled trial study was conducted in neonatal ward of Dhaka Shishu (Children) Hospital, Dhaka, from November, 2014 to October 2015. All preterm LBW neonates with birth weight 1250gm to 1800 gm., gestational age > 30 weeks to < 35 weeks, haemodynamically stable were given KMC and compared with conventional method of care. All the babies were monitored and data regarding weight, temperature, apnea, nosocomial infection, feeding, hospital stay and mortality etc. were recorded during the hospital stay and followed up to 40 weeks of gestational age. Statistic analysis was done by χ2, student t test etc. with SPSS-17 version.Results: comparison of 40 KMC babies with 40 control showed that rate of weight gain per day in KMC group was 18.1±7.7 gms and in control group, it was 13.0±4.5 gms ( p< 0.001). Apnea occurred less in KMC group (8% vs. 15%) (p=0.22) and episodes of hypothermia was also recorded less in KMC group (10% vs 18%)) (p=0.21). Culture positive sepsis was 15% in KMC group and 20% in control group (p=0.55 The mean time to achieve full enteral feed in KMC group was 9.1±2.4 days and 14.7±4,5 days (p < 0.001) in control group Ninety percent of KMC and 60% of control group babies were discharged with exclusive breast feeding (p=0.002). Mean hospital stay was 15.6 ± 10.6 days vs 18.2 ± 4.5 days, in KMC and control group respectively that was statistically insignificant, p=0.15. The mortality was 2(5%) in KMC group and those was 6(15%) in control group and that was also statistically insignificant (P=0.14).
Conclusion:In this study, KMC is effective for caring of LBW babies and has better effect on weight gaining and establishment of exclusive breast feeding. So KMC is recommended for caring of low birth weight infants.
Penaeus monodon is highly susceptible to vibriosis disease. Aims of the study were to identify the pathogen causing vibriosis in P. monodon through molecular techniques and develop a biocontrol method of the disease by application of herbal extracts. Shrimp samples were col¬lected aseptically from the infected farm and the bacteria were isolated from the infected region of those samples. Based on phenotypic identification, several isolates were identified as Vibrio sp. 16S rRNA gene sequences of the selected isolates exhibited 100% homology with V. alginolyticus strain ATCC 17749. An in vivo infection challenge test was performed by immersion method with V. alginolyticus where these isolates caused high mortality in juvenile shrimp with prominent symptoms of hepatopancreatic necrosis. Antibiogram profile of the isolates was determined against eleven commercial antibiotic discs whereas the isolates were found resistant to multiple antibiotics. A total of twenty-one herbal extracts were screened where Emblica officinalis, Allium sativum, and Syzygium aromaticum strongly inhibited the growth of V. alginolyticus in in vitro conditions. In in vivo conditions, the ethyl acetate extracts of E. officinalis and A. sativum successfully controlled the vibriosis disease in shrimp at a dose of 10 mg/g feed. This is the first report on molecular identification and biocontrol of V. alginolyticus in shrimp in Bangladesh.
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