Evaluation of natural protein-based nanofiber composite photocrosslinking hydrogel for skin wound regeneration

Fan, Yu; Pan, Jianfeng; Khan, Atta Ur Rehman; Zhao, Binan; Yuan, Zhengchao; Cai, Pengfei; Li, Xiaolong; El‐Newehy, Mohamed H.; El‐Hamshary, Hany; Morsi, Yosry; Sun, Bin; Cong, Ruijun; Mo, Xiumei

doi:10.1016/j.colsurfb.2023.113292

Cited by 3 publications

(6 citation statements)

References 41 publications

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“…Yu et al performed in situ photocuring with 365 nm (9 W) for 1 min in a Sprague Dawley full‐thickness rat wound healing model with GelMA‐based hydrogels (1% wt/vol LAP) containing various amounts of thioglycolic acid‐modified chitosan and 3‐buten‐1‐amine‐modified polycaprolactone nanofibers and observed composition‐dependent acceleration of wound healing with modified chitosan and nanofibers improving healing versus GelMA alone 37 . The same group recently reported an additional modification wherein the hydrogel platform was additionally supplemented with a decellularization product of dermal extracellular matrix‐methacryloyl/poly (ethylene glycol) diacrylate (ddECMMA/‐PEGDA) with 0.1% wt/vol LAP, which they observed further enhanced wound closure rates and collagen deposition in full‐thickness wounds in Sprague Dawley rats with in situ photocuring (365 nm, 9 W, 60 s) 38 . Xie et al modified GelMA hydrogels (0.25% wt/vol LAP) with a hyperbranched terpolymer containing imidazole groups to coordinate ascorbyl palmitate (AP) nanosheets and silver ions and observed enhanced wound closure with the combination of AP and silver ions with associated pro‐resolution chemokine phenotypes when tested in full‐thickness wounds in Sprague Dawley rats with 1 min of in situ photoactivation with 365‐nm light 39 .…”

Section: Uv Light‐activated Materialsmentioning

confidence: 99%

“… 37 The same group recently reported an additional modification wherein the hydrogel platform was additionally supplemented with a decellularization product of dermal extracellular matrix‐methacryloyl/poly (ethylene glycol) diacrylate (ddECMMA/‐PEGDA) with 0.1% wt/vol LAP, which they observed further enhanced wound closure rates and collagen deposition in full‐thickness wounds in Sprague Dawley rats with in situ photocuring (365 nm, 9 W, 60 s). 38 Xie et al modified GelMA hydrogels (0.25% wt/vol LAP) with a hyperbranched terpolymer containing imidazole groups to coordinate ascorbyl palmitate (AP) nanosheets and silver ions and observed enhanced wound closure with the combination of AP and silver ions with associated pro‐resolution chemokine phenotypes when tested in full‐thickness wounds in Sprague Dawley rats with 1 min of in situ photoactivation with 365‐nm light. 39 Interestingly, the authors described that rapid dressing changes could be performed by spraying 4°C Cu(NO 3 ) 2 solution on the dressings, causing a rapid release from tissue bonding.…”

Section: Uv Light‐activated Materialsmentioning

confidence: 99%

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In situ light‐activated materials for skin wound healing and repair: A narrative review

Yaron,

Gosangi,

Pallod

et al. 2024

Bioengineering & Transla Med

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Dermal wounds are a major global health burden made worse by common comorbidities such as diabetes and infection. Appropriate wound closure relies on a highly coordinated series of cellular events, ultimately bridging tissue gaps and regenerating normal physiological structures. Wound dressings are an important component of wound care management, providing a barrier against external insults while preserving the active reparative processes underway within the wound bed. The development of wound dressings with biomaterial constituents has become an attractive design strategy due to the varied functions intrinsic in biological polymers, such as cell instructiveness, growth factor binding, antimicrobial properties, and tissue integration. Using photosensitive agents to generate crosslinked or photopolymerized dressings in situ provides an opportunity to develop dressings rapidly within the wound bed, facilitating robust adhesion to the wound bed for greater barrier protection and adaptation to irregular wound shapes. Despite the popularity of this fabrication approach, relatively few experimental wound dressings have undergone preclinical translation into animal models, limiting the overall integrity of assessing their potential as effective wound dressings. Here, we provide an up‐to‐date narrative review of reported photoinitiator‐ and wavelength‐guided design strategies for in situ light activation of biomaterial dressings that have been evaluated in preclinical wound healing models.

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Section: Uv Light‐activated Materialsmentioning

confidence: 99%

Section: Uv Light‐activated Materialsmentioning

confidence: 99%

In situ light‐activated materials for skin wound healing and repair: A narrative review

Yaron,

Gosangi,

Pallod

et al. 2024

Bioengineering & Transla Med

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“…Since there is a less stringent requirement for engineering larger tissue constructs for skin tissue, nanofiber‐composite hydrogels having thin laminate structures, without having to develop short nanofibers and disperse them within the hydrogel, have been found useful for skin tissue regeneration, since it is important for the engineered skin tissue to possess high mechanical strength to withstand external forces generated during bodily movements. [ 113–117 ] For example, Liu et al. developed a PCL nanofiber‐composite alginate hydrogel to be used as an implantable skin substitute.…”

Section: Biomedical Applications Of Nanofiber‐composite Hydrogelsmentioning

confidence: 99%

“…also demonstrated that the inclusion of PCL nanofibers and chitosan into photocross‐linked gelatin hydrogel or decellularized matrix hydrogel expedited the skin wound healing process, likely due to the increased anti‐oxidant and anti‐bacterial effects as well as improved mechanical strength. [ 117 ]…”

Section: Biomedical Applications Of Nanofiber‐composite Hydrogelsmentioning

confidence: 99%

Emerging Technology of Nanofiber‐Composite Hydrogels for Biomedical Applications

Choi

Yun

Cha

2023

Macromolecular Bioscience

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Hydrogels and nanofibers have been firmly established as go‐to materials for various biomedical applications. They have been mostly utilized separately, rarely together, because of their distinctive attributes and shortcomings. However, the potential benefits of integrating nanofibers with hydrogels to synergistically combine their functionalities while attenuating their drawbacks are increasingly recognized. Compared to other nanocomposite materials, incorporating nanofibers into hydrogel has the distinct advantage of emulating the hierarchical structure of natural extracellular environment needed for cell and tissue culture. The most important technological aspect of developing “nanofiber‐composite hydrogel” is generating nanofibers made of various polymers that are crosslinked and short enough to maintain stable dispersion in hydrated environment. In this review, recent research efforts to develop nanofiber‐composite hydrogels are presented, with added emphasis on nanofiber processing techniques. Several notable examples of implementing nanofiber‐composite hydrogels for biomedical applications are also introduced.This article is protected by copyright. All rights reserved

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“…25 In parallel, Yu et al engineered novel protein-based photo-cross-linkable hydrogels utilizing nanofiber dispersions. 26 These hydrogels could be applied in a liquid form, adapt seamlessly to wound site, and solidify in situ, although they lacked critical antibacterial and anti-inflammatory functions. 27 Addressing the need for antibacterial capability, the common strategies included drug loading, cross-linking with antibacterial polymer, metal ion incorporation, and photodynamic or photothermal methods.…”

Section: Introductionmentioning

confidence: 99%

Photo-Cross-Linkable Hydrogel with Lubricating, Antimicrobial, and Antioxidant Properties for Bacteria-Infected Wound Healing

Guo,

Wang,

Wang

et al. 2024

Chem. Mater.

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Wound healing is a prolonged physiological process involving a series of complicated biological responses influenced by various factors, such as bacterial infection and oxidative damage. Existing treatments, while effective, have certain limitations in terms of biocompatibility, responsiveness to the wound environment, and efficacy in promoting tissue regeneration. To address these shortcomings, bioinspired by hydration lubrication mechanism of articular cartilage, we successfully designed and developed an injectable in situ photo-cross-linkable hydrogel, which was synthesized via modifying aminated hyaluronic acid with a polymer obtained by free radical polymerization of o-nitrobenzyl alcohol derivative (NB) and 2-methoxyethyl phosphocholine (MPC). The hydrophilic hydration layer formed around the zwitterionic charges in MPC endowed the hydrogel with enhanced lubrication and antimicrobial effects, whereas the hydroxymethyl group in NB enabled the hydrogel to process ultraviolet light-induced cross-linking property. The hydrogel, doped with polydopamine nanoparticles, facilitated multifaceted wound healing by the mechanism of photothermally responsive antibacterial, anti-inflammation, and angiogenesis. Specifically, upon injection of the hydrogel precursor solution into the wound site and exposure to ultraviolet light, the hydrogel cross-linked and adhered closely to the skin tissues, achieving hemostasis and exudate absorption. Additionally, the hydrogel showed excellent reactive oxygen species scavenging property, reducing cellular oxidative stress and meanwhile promoting the bactericidal effect with near-infrared light irradiation. Furthermore, the hydrogel, with its networked porous structure, was conducive to cell adhesion and proliferation, remarkably enhancing the cellular activity and tissue regeneration. The wound-healing performances of the hydrogel were investigated in both in vitro and in vivo experiments, showcasing its potential for wound treatment applications, offering a promising improvement over the current methods by providing a photothermal responsive, biocompatible, and effective healing process.

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Evaluation of natural protein-based nanofiber composite photocrosslinking hydrogel for skin wound regeneration

Cited by 3 publications

References 41 publications

In situ light‐activated materials for skin wound healing and repair: A narrative review

In situ light‐activated materials for skin wound healing and repair: A narrative review

Emerging Technology of Nanofiber‐Composite Hydrogels for Biomedical Applications

Photo-Cross-Linkable Hydrogel with Lubricating, Antimicrobial, and Antioxidant Properties for Bacteria-Infected Wound Healing

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