Evaluation of Narrow-Band Imaging as a Complementary Method for the Detection of Bladder Cancer

Tatsugami, Katsunori; Kuroiwa, Kentaro; Nishiyama, Hiroyuki; Watanabe, Jun; Ishikawa, Satoshi; Shinohara, Nobuo; Sazawa, Ataru; Fukushima, Shoji; Naito, Seiji

doi:10.1089/end.2010.0055

Cited by 76 publications

(78 citation statements)

References 21 publications

(8 reference statements)

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“…There have been few previous comparisons of recurrence in NMIBC following NBI-TUR and WLI-TUR (4). The significantly lower recurrence rate with NBI-TUR compared to WLI-TUR may be due to the significantly higher tumor detection rate with NBI-TUR found in the NMIBC patients in the present study and in previous studies (4)(5)(6)(7)(8)(9).…”

Section: Discussionsupporting

confidence: 41%

“…Specificity and accuracy in the NBI-TUR group were significantly improved by experience, but the specificity only reached 84.5% in the later cases and certain lesions, including CIS, could not be detected under NBI. Furthermore, bleeding or active inflammation of the bladder means that the detection of abnormal lesions using NBI is difficult, as enhanced images are generated by light emission from target areas in two narrow wavebands that are strongly absorbed by hemoglobin (7). These results indicate the current technical limitations of NBI.…”

Section: Discussionmentioning

confidence: 99%

“…NBI is useful for the identification and evaluation of early-stage cancer in gastrointestinal endoscopy (3), and the utility of NBI for increasing tumor detection and decreasing recurrence compared with WLI has been shown in non-muscle invasive bladder cancer (NMIBC) (4)(5)(6)(7)(8)(9). However, it is unclear if transurethral resection (TUR) using NBI (NBI-TUR) reduces the tumor recurrence rate compared with TUR under conventional WLI (WLI-TUR).…”

Section: Introductionmentioning

confidence: 99%

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Advantage of transurethral resection with narrow band imaging for non-muscle invasive bladder cancer

et al. 2015

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Abstract. The aim of the present study was to compare the benefits of transurethral resection (TUR) under narrow band imaging (NBI-TUR) and TUR under conventional white light imaging (WLI-TUR) for non-muscle invasive bladder cancer (NMIBC). The study cohort consisted of 135 patients with NMIBC who were followed up for ≥1 year after TUR and who received no additional post-operative treatment. In the WLI-TUR group (n=78), systematic intravesical observation under WLI was followed by a multiple site biopsy (MSB), after which lesions detected as positive findings were resected completely under WLI. In the NBI-TUR group (n=57), similar observation under WLI was followed by systematic intravesical observation under NBI. Following MSB under NBI, TUR was performed for all lesions detected as positive findings under NBI. The sensitivity, specificity, positive-predictive value, negative-predictive value (NPV) and accuracy in the NBI-TUR group were calculated using results from the cystoscopical and pathological examinations of MSB samples under WLI and NBI. The tumor recurrence rate was analyzed in the two groups. Background factors did not differ significantly between the two groups, with the exception of the observation period (31.0 vs. 15.0 months; P<0.01). The procedure under NBI exhibited significantly higher sensitivity (95.0 vs. 70.0%; P<0.01) and NPV (97.1 vs. 86.8%; P<0.01) compared with the procedure under WLI. The 1-year recurrence rate in the NBI-TUR group was significantly lower than that in the WLI-TUR group (21.1 vs. 39.7%; P=0.016). In conclusion, the present study indicated that NBI-TUR is more advantageous than conventional WLI-TUR for patients with NMIBC.

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Section: Discussionsupporting

confidence: 41%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Advantage of transurethral resection with narrow band imaging for non-muscle invasive bladder cancer

et al. 2015

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“…In other series, NBI cystoscopy detected additional tumors in 35.9-56% patients with UC. The sensitivity and specificity ranged from 92.7 to 100% and 68.4 to 81.8%, which is higher than our results [3,5,6,8] . We attributed this difference to the specific patient group of our study.…”

Section: Discussioncontrasting

confidence: 89%

Narrow-Band Imaging Flexible Cystoscopy in the Detection of Clinically Unconfirmed Positive Urine Cytology

Zhu¹,

Shen²,

Ye³

et al. 2011

Urol Int

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Introduction: The objective of this study was to investigate the value of narrow-band imaging (NBI) cystoscopy in the detection of patients with positive voided urine cytology (VUC) who have no evidence of disease after standard initial investigations. Patients and Methods: Between February 2009 and December 2010, 12 patients with positive or suspicious VUC but no regular endoscopic evidence of cancer were investigated with NBI flexible cystoscopy. All the specimens were biopsied both under NBI and white light imaging (WLI). Random biopsies of bladder and prostatic urethra were performed in cases without suspect lesions. Results: Fourteen NBI cystoscopies were carried out in 12 patients. Non-muscle-invasive bladder cancer was diagnosed in 5 of 12 (42%) patients on the first NBI. One patient had carcinoma in situ diagnosed on repeat NBI 3 months later. The sensitivity and specificity in diagnosing unconfirmed positive VUC was 78 and 91% for NBI vs. 50 and 80% for WLI. Conclusions: NBI cystoscopy significantly improves detection of unconfirmed positive VUC over WLI. It should be carried out early in the investigation of such patients before random biopsies and ureteroscopy.

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“…Cauberg et al, reports improved detection of both high and low grade tumors when compared to white light cystoscopy [22]. Tamsugami et al, reported a sensitivity and specificity of 92.7% and 70.9%, respectively [27]. Herr et al, showed that the use of NBI was associated with fewer recurrences and longer recurrence-free intervals [28].…”

Section: Narrow-band Imagingmentioning

confidence: 99%

Advances in cystoscopic surveillance of superficial bladder cancer: detection of the invisible tumor

Hale¹,

Deem²

2013

Med Instrum

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Objectives: To review recent advances in imaging modalities available for diagnosis and surveillance of superficial bladder cancer. Methods: Detailed PubMed searches were performed using the terms "fluorescence cystoscopy," "narrow-band imaging," and "optical coherence tomography" with "bladder cancer" and "urothelial carcinoma." Relevant literature was selected for analysis. We explored the clinical evidence to support the use of these technologies for the detection and surveillance of bladder cancer. Results: Fluorescence cystoscopy, narrow-band imaging, and optical coherence tomography are designed to improve the visualization of bladder cancer. These technological advancements have demonstrated an improvement in the detection of bladder cancer, including carcinoma in situ. Fluorescence cystoscopy has also been shown to decrease residual tumor rates and improve recurrence free survival. Both fluorescence cystoscopy and narrow-band imaging have a relatively high false positive rate. Optical coherence tomography can estimate bladder tumor stage without an invasive biopsy, however data is lacking in diagnostic accuracy. Conclusions: Evidence for the utility of fluorescence cystoscopy, narrow-band imaging, and optical coherence tomography has begun to compile. Fluorescence cystoscopy has the most evidence supporting its clinical applications. Low specificity currently limits these novel technologies from widespread use. More prospective studies are needed particularly of narrow band imaging, and optical coherence tomography. In addition, further research is necessary to determine the long-term impact of these technologies on recurrence, progression, and survival of bladder cancer.

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Evaluation of Narrow-Band Imaging as a Complementary Method for the Detection of Bladder Cancer

Abstract: NBI is a simple and effective method for identifying bladder tumors including CIS without the need for dyes because of its high sensitivity, high NPV, and low NLR.

Cited by 76 publications

References 21 publications

Advantage of transurethral resection with narrow band imaging for non-muscle invasive bladder cancer

Advantage of transurethral resection with narrow band imaging for non-muscle invasive bladder cancer

Narrow-Band Imaging Flexible Cystoscopy in the Detection of Clinically Unconfirmed Positive Urine Cytology

Advances in cystoscopic surveillance of superficial bladder cancer: detection of the invisible tumor

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