Evaluation of Myocardial Injury using Standard Diagnostic Tools and Tissue Doppler Imaging in Blunt Trauma Chest

Gautam, Parshotam Lal; Luthra, Neeru; Kaur, Manpreet; Singh, Jaspal; Wander, Gurpreet Singh; Tandon, Rohit; Namrata, -; Gautam, Nikhil

doi:10.7860/jcdr/2017/22746.10069

Cited by 4 publications

(4 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, the serum levels of CK, CK-MB and LDH, which are indicators of cardiac function, were all increased following Chuan-wu administration. The serum levels of CK, CK-MB and LDH are quantitative indicators of loss of membrane integrity during myocardial damage ( 21 ). The increase in CK, CK-MB and LDH suggested that Chuan-wu can affect the integrity of myocardial cell membranes.…”

Section: Discussionmentioning

confidence: 99%

Protective effect of berberine on aconite‑induced myocardial injury and the associated mechanisms

Chen

Guo

et al. 2018

Mol Med Report

View full text Add to dashboard Cite

Aconitum plants, which have analgesic, diuretic and anti-inflammatory effects, have been widely used to treat various types of disease. However, the apparent toxicity of Aconitum-derived agents, particularly in the cardiovascular system, has largely limited their clinical use. Thus, the present study investigated whether berberine (Ber), an isoquinoline alkaloid, may reduce myocardial injury induced by aconitine (AC) in rats and the underlying mechanisms. Rats (n=40) were randomly divided into four groups: Control, Chuan-wu and Chuan-wu + Ber (8 and 16 mg/kg doses). Electrocardiograms (ECG) of the rats were recorded and serum biomarkers of cardiac function [lactate dehydrogenase (LDH), creatine kinase (CK) and CK-MB] were assayed. Histopathological changes were assessed using myocardial tissue sectioning and hematoxylin and eosin staining. Additionally, the effects of Ber on AC-induced arrhythmias in rats were observed. The changes in ECG following AC perfusion were observed, and the types and onset time of arrhythmias were analyzed. Furthermore, the effects of Ber and AC on papillary muscle action potentials were observed. The results suggested that Ber ameliorated myocardial injury induced by Chuan-wu, which was indicated by reduced arrhythmias and decreased LDH, CK and CK-MB levels in serum. Furthermore, histological damage, including dilation of small veins and congestion, was also markedly attenuated by Ber. In addition, the occurrence of arrhythmias was significantly delayed, and the dosage of AC required to induce arrhythmias was also increased by Ber pretreatment. Additionally, AC-induced changes in action potential amplitude, duration of 30% repolarization and duration of 90% repolarization in the papillary muscle were attenuated by Ber. All of these results indicate that Ber had a preventive effect on acute myocardial injury induced by Chuan-wu and arrhythmias caused by AC, which may be associated with the inhibition of delayed depolarization and triggered activity caused by AC. Thus, combination treatment of Ber with Aconitum plants may be a novel strategy to prevent AC-induced myocardial injury in clinical practice.

show abstract

Section: Discussionmentioning

confidence: 99%

Protective effect of berberine on aconite‑induced myocardial injury and the associated mechanisms

Chen

Guo

et al. 2018

Mol Med Report

View full text Add to dashboard Cite

show abstract

“…Therefore, there is no standard test for diagnosing myocardial contusion in patients who do not undergo surgery. To evaluate and estimate myocardial contusion or myocardial injury, several studies have proposed and reported outcomes by analyzing combinations of diagnostic tools such as electrocardiography, biomarkers such as troponin I and T, TTE, or transesophageal echocardiography [9,[11][12][13].…”

Section: Discussionmentioning

confidence: 99%

Effects of Trauma-Related Shock on Myocardial Function in the Early Period Using Transthoracic Echocardiography

Dae-Sung

2021

J Trauma Inj

View full text Add to dashboard Cite

The present study aimed to analyze the effect of trauma-related shock on myocardial function in the early stages of trauma through transthoracic echocardiography (TTE) findings. methods: We performed a retrospective review and analysis of the medical records of patients aged ≥18 years who were evaluated by TTE within 2 days of admission for trauma-related shock (n=72). Patients were selected from a group of 739 patients admitted with trauma-related shock between January 2014 and December 2016. results: The incidence rate of myocardial dysfunction in the left ventricle (LV) was 6.8% (5/72), with rates of 7.7% (4/52) in the thoracic injury group and 5.0% (1/20) in the non-thoracic injury group. In the diastolic function of LV, relaxation abnormality was present in 55.8% (29/52) of patients in the thoracic injury group and 50% (10/20) of patients in the non-thoracic injury group. Conclusions: This study may suggest that traumatic shock without thoracic injury may influence myocardial function in the early stages after trauma. Therefore, evaluation of myocardial function may be needed for patients experiencing shock after trauma, regardless of the presence of thoracic injury.

show abstract

“…There are no definitive diagnostic criteria, but various combinations of clinical picture, ECG, troponin, or cardiac imaging were used to define BCI. Therefore, the incidence of BCI in patients with BTT varies from 3% to 56% (65-67). The release of troponin reflecting myocardial cell injury is believed to be because of mechanical transmission of force through the chest wall (68).…”

Section: Cardiac Contusionmentioning

confidence: 99%

Turkish Society of Cardiology Consensus Paper onThe Rational Use of Cardiac Troponins in Daily Practice

Okyay

Sadıç²,

Şahinarslan³

et al. 2019

Anatol J Cardiol

View full text Add to dashboard Cite

Evaluation of Myocardial Injury using Standard Diagnostic Tools and Tissue Doppler Imaging in Blunt Trauma Chest

Cited by 4 publications

References 23 publications

Protective effect of berberine on aconite‑induced myocardial injury and the associated mechanisms

Protective effect of berberine on aconite‑induced myocardial injury and the associated mechanisms

Effects of Trauma-Related Shock on Myocardial Function in the Early Period Using Transthoracic Echocardiography

Turkish Society of Cardiology Consensus Paper onThe Rational Use of Cardiac Troponins in Daily Practice

Contact Info

Product

Resources

About