“…Improved tissue segmentation can be achieved through combining multispectral MRI contrasts in the segmentation process (Alfano et al, ; Ashburner & Friston, ; Ashburner & Friston, ; Fletcher, Barsotti, & Hornak, ; Lambert, Lutti, Helms, Frackowiak, & Ashburner, ; Vannier et al, ). Recent studies have confirmed superiority of multispectral over conventional T1‐only segmentation by addressing issues such as overestimation of dura and vessels as GM and also improve cortical GM segmentation (Lindig et al, ; Viviani, Pracht, et al, ; Viviani, Stocker, et al, ). With the addition of T2/T2‐FLAIR weighted, VBM variants (T1 + FLAIR, T1 + T2) have also shown improved lesion detection over T1‐only VBM, in both lesional and non lesional MRI focal epilepsy (Kotikalapudi et al, ; Lindig et al, ).…”