Evaluation of Monooleine Aqueous Dispersions as Tools for Topical Administration of Curcumin: Characterization, In Vitro and Ex-Vivo Studies

Puglia, Carmelo; Cardile, Venera; Panico, Annamaria; Crascì, Lucia; Offerta, Alessia; Caggia, Silvia; Drechsler, Markus; Mariani, Paolo; Cortesi, Rita; Esposito, Elisabetta

doi:10.1002/jps.23605

Cited by 41 publications

(28 citation statements)

References 45 publications

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“…This can be explained in the formation of complex lyotropic liquid crystalline phases resulting from the solubilization of curcumin in monoolein-based systems (Puglia et al, 2013). Therefore, monoolein-based systems were selected as most suitable candidate for dispersion in aqueous phase.…”

Section: Resultsmentioning

confidence: 99%

Submicron complex lipid carriers for curcumin delivery to intestinal epithelial cells: Effect of different emulsifiers on bioaccessibility and cell uptake

Yücel

Quagliariello

Iaffaioli

et al. 2015

International Journal of Pharmaceutics

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Section: Resultsmentioning

confidence: 99%

Submicron complex lipid carriers for curcumin delivery to intestinal epithelial cells: Effect of different emulsifiers on bioaccessibility and cell uptake

Yücel

Quagliariello

Iaffaioli

et al. 2015

International Journal of Pharmaceutics

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“…Therefore, many delivery strategies for CUR have been proposed, mainly based on the use of lipid matrixes such as liposomes, solid lipid nanoparticles and cyclodextrins . In particular, our group has proposed the solubilization of CUR in nanostructured lipid dispersions (NLDs) . Lipid dispersions enable to gain dissolution and controlled delivery of active molecules, at the same time improving drug bioavailability and reducing side effects .…”

Section: Introductionmentioning

confidence: 99%

Effect of new curcumin‐containing nanostructured lipid dispersions on human keratinocytes proliferative responses

Esposito

Sticozzi

Ravani

et al. 2015

Experimental Dermatology

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This study describes the production and characterization of nanostructured lipid dispersions (NLDs) containing curcumin (CUR) as new tools for curcumin topical delivery. Four types of NLDs based on monoolein in association with different emulsifiers were produced: Na cholate and poloxamer 407 (NLD1), poloxamer alone (NLD2), the mixture of Na cholate and Na caseinate (NLD3) and Na cholate alone (NLD4). Morphology and dimensional distribution of lipid dispersions were investigated by cryo-TEM and photon correlation spectroscopy (PCS). In vitro studies based on Franz cell, membrane nylon and stratum corneum-epidermis (SCE) were carried out to compare the four NLDs in terms of cytotoxicity in human keratinocytes and CUR diffusion. Our PCS studies showed differences in particles diameter among the different NLDs. In addition, cytotoxicity results in HaCaT cells evidenced that NLD1 and NLD2 were toxic at doses over 1 μm. Therefore, cryo-TEM was determined only for NLD3 and NLD4 showing that CUR did not affect their structure. Diffusion measurement in SCE and nylon membrane evidenced that CUR had a time-delayed release for NLD4. The 'wound healing' effect of NLD3 and NLD4 with and without CUR analysed keratinocytes in vitro, and a clear inhibition of cell proliferation/migration by CUR was observed. This effect was mediated by the inhibition of cyclin D1 expression as a consequence of the impaired NFkB activation. This study confirms the antiproliferative properties of CUR and evidenced a new possible model of CUR topical delivery for hyperproliferative cutaneous diseases such as psoriasis.

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“…All the obtained diffusion rates were determined six times in independent experiments and the mean values ± standard deviations were calculated. In the case of CUR, samples of dried stratum corneum epidermis membranes (SCE) were rehydrated by immersion in distilled water at room temperature for 1 h before being mounted in Franz-type diffusion cells supplied by LGA (Berkeley, CA) as previously reported [46]. The exposed skin surface area was 0.78 cm 2 area (1 cm diameter orifice).…”

Section: In Vitro Experimentsmentioning

confidence: 99%

Gelified reverse micellar dispersions as percutaneous formulations

Esposito

Ravani

Mariani

et al. 2016

Journal of Drug Delivery Science and Technology

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Evaluation of Monooleine Aqueous Dispersions as Tools for Topical Administration of Curcumin: Characterization, In Vitro and Ex-Vivo Studies

Cited by 41 publications

References 45 publications

Submicron complex lipid carriers for curcumin delivery to intestinal epithelial cells: Effect of different emulsifiers on bioaccessibility and cell uptake

Submicron complex lipid carriers for curcumin delivery to intestinal epithelial cells: Effect of different emulsifiers on bioaccessibility and cell uptake

Effect of new curcumin‐containing nanostructured lipid dispersions on human keratinocytes proliferative responses

Gelified reverse micellar dispersions as percutaneous formulations

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