Evaluation of monoclonal anti-Rh antibodies as reagents for blood grouping and for the identification of red cell membrane components associated with Rh antigen activity

Moore, Stephen; Green, C; McGowan, A.

doi:10.1016/s0338-4535(88)80098-9

Cited by 2 publications

(1 citation statement)

References 3 publications

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“…In this paper, a further serological analysis is de scribed of blood donor red cells that express the category VI partial D antigen, and the results suggest once more [15][16][17] the existence of serological heterogeneity within this partial D category.…”

Section: Introductionmentioning

confidence: 93%

Serological Characteristics of Partial D Antigen Category VI in 8 Unrelated Blood Donors

Rhenen¹,

Thijssen²,

Overbeeke³

1994

Vox Sanguinis

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Classification of subjects with a partial D antigen is traditionally performed with immune anti-D sera. The development of monoclonal antibodies enables a fine analysis to be made of the specificity of the epitopes that are present or missing in these cases. A systematic search in a Caucasian donor population of 17,500 revealed 8 unrelated male individuals (frequency 0.05%) with a red cell phenotype characteristic of partial D category VI, but without anti-D in their serum. The relation to the ‘classic’ partial D category VI was investigated and is discussed, as is the observed serological heterogeneity of the partial D category VI group. Clinical consequences for the prevention of immunization of these subjects are mentioned.

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Section: Introductionmentioning

confidence: 93%

Serological Characteristics of Partial D Antigen Category VI in 8 Unrelated Blood Donors

Rhenen¹,

Thijssen²,

Overbeeke³

1994

Vox Sanguinis

View full text Add to dashboard Cite

show abstract

Serological Characteristics of Partial D Antigen Category VI in 8 Unrelated Blood Donors

Rhenen

Thijssen²,

Overbeeke

1994

Vox Sanguinis

View full text Add to dashboard Cite

Classification of subjects with a partial D antigen is traditionally performed with immune anti-D sera. The development of monoclonal antibodies enables a fine analysis to be made of the specificity of the epitopes that are present or missing in these cases. A systematic search in a Caucasian donor population of 17,500 revealed 8 unrelated male individuals (frequency 0.05%) with a red cell phenotype characteristic of partial D category VI, but without anti-D in their serum. The relation to the 'classic' partial D category VI was investigated and is discussed, as is the observed serological heterogeneity of the partial D category VI group. Clinical consequences for the prevention of immunization of these subjects are mentioned.

show abstract

Evaluation of monoclonal anti-Rh antibodies as reagents for blood grouping and for the identification of red cell membrane components associated with Rh antigen activity

Cited by 2 publications

References 3 publications

Serological Characteristics of Partial D Antigen Category VI in 8 Unrelated Blood Donors

Serological Characteristics of Partial D Antigen Category VI in 8 Unrelated Blood Donors

Serological Characteristics of Partial D Antigen Category VI in 8 Unrelated Blood Donors

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