Evaluation of microvascular changes in the macular area of eyes with rhegmatogenous retinal detachment without macular involvement using swept-source optical coherence tomography angiography

Yoshikawa, Yuji; Shoji, T.; Kanno, Junji; Ibuki, Hisashi; Ozaki, Kimitake; Ishii, Hirokazu; Ichikawa, Yoshikazu; Kimura, Ikuo; Shinoda, Kei

doi:10.2147/opth.s177933

Cited by 33 publications

(30 citation statements)

References 18 publications

(15 reference statements)

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“…31 Tsen et al prospectively evaluated 28 eyes with mac-off RRD using OCT-A and reported VD to be significantly lower in the SCP and DCP in the RD eyes compared to the fellow eyes 32 while Yoshikawa et al investigated 5 eyes with mac-on RRD pre-operatively and reported parafoveal VD and FAZ to be not significantly different between the eyes with RRD and the fellow eye suggesting that the macular microvasculature remains intact. 30 In our study of 17 eyes with mac-off RD, we found a reduction of the VD in the DCP employing OCT-A. Furthermore, we report worse visual outcomes in eyes which had reduced VD in the deep capillary plexus compared with those that did not.…”

Section: Discussionmentioning

confidence: 47%

“…It has been extensively investigated in macular degeneration, retinal vein occlusion, diabetic retinopathy, posterior uveitis and optic neuropathies. [22][23][24][25][26][27] Recently, few reports investigated OCT-A parameters after mac-on [28][29][30] or mac-off 28,29,31,32 RD repair including vascular density (VD) and FAZ area and correlated those with visual function. Building on those reports, we herein employed OCT-A to evaluate microvascular changes in the superficial (SCP) and deep capillary plexuses (DCP), choriocapillaris and the FAZ area and their correlation with final best corrected visual acuity (BCVA) in eyes after mac-off RRD repair using the fellow eyes as controls.…”

Section: Background and Objectivementioning

confidence: 99%

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<p>Retinal Microvasculature Changes After Repair of Macula-off Retinal Detachment Assessed with Optical Coherence Tomography Angiography</p>

McKay¹,

Vingopoulos²,

Wang³

et al. 2020

OPTH

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To characterize the microvascular retinal changes after repair of macula-off rhegmatogenous retinal detachment (RRD) using optical coherence tomography angiography (OCT-A). Patients and Methods: A retrospective review of patients who underwent repair of macula-off RRD. Fellow unaffected eyes were used as controls. Post-operative OCT-A allowed comparison of vessel density (VD) and foveal avascular zone (FAZ) area in the superficial and deep retinal capillary plexus (DCP) as well as VD in the choriocapillaris layer. Results: Seventeen eyes of 17 RRD patients were included in the final analysis. There was a reduction in VD of the deep retinal capillary plexus in affected eyes compared to fellow eyes (p = 0.046). RRD eyes with reduced VD in DCP compared with their fellow control eyes had worse visual acuity after repair compared to those without (p = 0.032). No significant microvasculature changes were detected in the FAZ area and VD in the superficial capillary plexus and choriocapillaris compared to fellow eyes. Conclusion: In macula-off RRD eyes, significant microvascular changes were detected in the DCP using OCT-A even after successful anatomical repair. Decreased VD in the DCP compared to the fellow healthy eyes was correlated with worse visual acuity.

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Section: Discussionmentioning

confidence: 47%

Section: Background and Objectivementioning

confidence: 99%

<p>Retinal Microvasculature Changes After Repair of Macula-off Retinal Detachment Assessed with Optical Coherence Tomography Angiography</p>

McKay¹,

Vingopoulos²,

Wang³

et al. 2020

OPTH

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show abstract

“…In this study, we investigated the vasculature parameters (VD, CCP flow area and FAZ) of the macular region in eyes successfully treated with PR for primary macula‐on and macula‐off RRD and assessed their correlation with functional and anatomical results. Previous studies have investigated the alterations in microvasculature structure after PPV for RRD repair; this is the first study using OCTA to evaluate and quantitate VD in superficial, deep retinal, and choroidal capillary plexuses after PR (Woo et al 2018; Yoshikawa et al 2018; Bonfiglio et al 2019).…”

Section: Discussionmentioning

confidence: 99%

Microvascular retinal alterations in rhegmatogenous retinal detachment after pneumatic retinopexy

Kaderli

Karalezlı

Sül

2020

Acta Ophthalmologica

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Purpose To evaluate the macular microvascularity with optical coherence tomography angiography (OCTA) in rhegmatogenous retinal detachment (RRD) which were successfully treated with pneumatic retinopexy (PR). Methods Thirty eyes of thirty patients who were treated with PR (12 eyes with macula‐off RRD and 18 eyes with macula‐on RRD) were included in this prospective study. OCTA was used to evaluate the macular perfusion changes postoperatively at 1 and 3 months. The fellow eyes (30 eyes) were used as control for comparison. Parafoveal retinal thickness (RT) and best‐corrected visual acuity (BCVA) were evaluated. Results Vessel density (VD) in SCP, DCP and choriocapillaris plexus (CCP) flow area was significantly lower in the macula‐off group one month after the PR (p < 0.001). In the macula‐off group, VD in SCP, DCP and CCP flow area significantly increased at months 3 (p < 0.001, p < 0.001, p = 0.009). The inner RT, RT and FAZ decreased three months after PR (p < 0.001, p = 0.001, <0.001). The FAZ was significantly larger in the macula‐off group at third months after PR (p < 0.001). The inner RT was higher in the macula‐off group at third month (p = 0.012). There was no significant difference between the groups in means of final VD, CCP flow area and RT. There was also a negative correlation between the final BCVA (logMAR) and FAZ at month 3 (r = 0.776, p = 0.003). Conclusion Optical coherence tomography angiography evaluation of macular capillary plexuses may be useful for predicting vascular structural changes in patients undergoing PR.

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“…Although there have already been several reports that examined the FAZ area in various retinal diseases and glaucoma [11-13, 23, 24],the magnification effect was not always considered in the evaluation on the FAZ area. Linderman et al [14] reported that both axial length and refraction abnormality influence the measurement results due to the magnification effect.…”

Section: Discussionmentioning

confidence: 99%

Magnification Effect of Foveal Avascular Zone Measurement Using Optical Coherence Tomography Angiography

et al. 2020

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The aim of this study was to evaluate the foveal avascular zone (FAZ) of healthy subjects and examine the magnification effect. Methods: A total of 33 healthy volunteers were enrolled and all subjects were eligible for analysis. Optical coherence tomography angiography (OCTA) examination scanned 3 × 3 mm of the macular area. The FAZ area was measured on the superficial OCTA en face image with and without correction by axial length. The relationship between changes in the FAZ area after correction with the axial length was examined. Results: The mean age was 21.9 ± 0.6 years. The mean axial length was 24.87 ± 1.17 mm and mean spherical equivalent (SE) value was-3.64 ± 2.83 diopters (D). The FAZ area was 0.26 ± 0.10 mm 2 before the axial length correction and 0.27 ± 0.10 mm 2 after the correction. In the eyes that had an axial length longer than or equal to 26 mm or SE less than or equal to-6 D, the FAZ area after correction was significantly larger than that before correction (p < 0.01).

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Evaluation of microvascular changes in the macular area of eyes with rhegmatogenous retinal detachment without macular involvement using swept-source optical coherence tomography angiography

Cited by 33 publications

References 18 publications

<p>Retinal Microvasculature Changes After Repair of Macula-off Retinal Detachment Assessed with Optical Coherence Tomography Angiography</p>

<p>Retinal Microvasculature Changes After Repair of Macula-off Retinal Detachment Assessed with Optical Coherence Tomography Angiography</p>

Microvascular retinal alterations in rhegmatogenous retinal detachment after pneumatic retinopexy

Magnification Effect of Foveal Avascular Zone Measurement Using Optical Coherence Tomography Angiography

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