Evaluation of Microcrystalline Chitosan and Fibrin Membranes as Platelet-Derived Growth Factor-BB Carriers with Amoxicillin

Bodek, Kazimiera Henryka; Nowak, Karolina; Kozakiewicz, Marcin; Bodek, Andrzej; Michalska, Marta

doi:10.1155/2015/386251

Cited by 4 publications

(6 citation statements)

References 46 publications

(57 reference statements)

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“…Profiles of Lid HCl release (Figures and ) revealed that the drug release was a two‐stage process with an initial faster effect and a slower second stage . In the first phase, this process was a function of the change in the drug concentration in the surface layer, of which the total release of particles was more easily accessible.…”

Section: Resultsmentioning

confidence: 99%

“…The kinetics of the drug release for the presented formulations as described previously could be depicted as the first‐order equation with two exponential functions:

M_{t} / M_{\infty} = A_{0} + A_{1} true[1 - exp true(- k_{1} t true) true] + A_{2} true[1 - exp true(- k_{2} t true) true]

where A 0 is the percentage of substance not released from the surface and bonded with the polymeric formulation, A 1 is the percentage of substance released during the first phase, A 2 is the percentage of substance released during the second phase, and k 1 and k 2 are the rate constants for the first and second release phases.…”

Section: Methodsmentioning

confidence: 99%

“…The kinetics of the drug release for the presented formulations as described previously 45 could be depicted as the first-order equation with two exponential functions:…”

Section: Article Wileyonlinelibrarycom/appmentioning

confidence: 99%

“…[42][43][44] Profiles of Lid HCl release ( Figures 6 and 7) revealed that the drug release was a two-stage process with an initial faster effect and a slower second stage. 45,51,52 In the first phase, this process was a function of the change in the drug concentration in the surface layer, of which the total release of particles was more easily accessible. The second phase corresponded to the effective delayed release of the drug substance from the deeper layers of the polymer formulations.…”

Section: In Vitro Release Of Lid Hclmentioning

confidence: 99%

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In vitro evaluation of polymeric formulations designed for use in alveolar osteitis

Nowak

Szterk

Szymborski

et al. 2015

J of Applied Polymer Sci

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In this article, we present a potential use of biodegradable polymers as a drug‐delivery system designed for alveolar osteitis (AO) management. The release characteristics of lidocaine hydrochloride from alginate or hyaluronate xerogels, which covered the microcrystalline chitosan scaffold, were examined as drug carriers, wound dressings, and potential devices in bone regeneration. The materials were characterized by Fourier transform infrared spectroscopy to confirm that there was no additional covalent bonding between the polymeric membranes and the anesthetic agent. Surface‐eroding matrices (ca. 120 μm) encapsulated the main substance, and the morphologies of all of the structures were measured by scanning electron microscopy. Positive results were obtained, and the data suggested an important impact of materials selection on the physicochemical properties and drug release. Additionally, the mechanical properties, such as the hardness, adhesiveness, springiness, and cohesiveness, of the tested materials were evaluated. A study of the swelling confirmed one of the assumptions that the materials could be used as a potential wound dressing and emphasized the resistance of the materials in the condition imitating the movement of the masticatory system. A cytotoxicity test of the formulations was performed to prove the materials’ nontoxicity. The aim of this study was to design and propose an in vitro evaluation of a new drug formulation as a potential application for the treatment of AO. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016, 133, 42991.

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Section: Resultsmentioning

confidence: 99%

“…The kinetics of the drug release for the presented formulations as described previously could be depicted as the first‐order equation with two exponential functions:

M_{t} / M_{\infty} = A_{0} + A_{1} true[1 - exp true(- k_{1} t true) true] + A_{2} true[1 - exp true(- k_{2} t true) true]

Section: Methodsmentioning

confidence: 99%

“…The kinetics of the drug release for the presented formulations as described previously 45 could be depicted as the first-order equation with two exponential functions:…”

Section: Article Wileyonlinelibrarycom/appmentioning

confidence: 99%

Section: In Vitro Release Of Lid Hclmentioning

confidence: 99%

See 2 more Smart Citations

In vitro evaluation of polymeric formulations designed for use in alveolar osteitis

Nowak

Szterk

Szymborski

et al. 2015

J of Applied Polymer Sci

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“…The characteristic peak at 2920 cm -1 is attributed to the C-H stretching vibration. Moreover, a peak at 1590 cm -1 (related to the C=O stretching vibration of carboxymethyl) is shifted to a lower wavenumber as a result of the effect of the lone pair electrons on the adjacent oxygen atoms [26]. Simultaneously, the brands at 1420 cm -1 and 1330 cm -1 are ascribed to the in-plane blending of -OH (on the different site of the backbones).…”

Section: Characterization Of Cs/cmc Amphoteric Ion Exchangementioning

confidence: 96%

The Amphoteric Ion Exchange Membrane Based on CS/CMC for Tobacco-Protein Adsorption and Separation from Tobacco Extract

Ling

Zhou

et al. 2019

International Journal of Polymer Science

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A macroporous amphoteric ion exchange membrane was prepared by blending chitosan (CS) and carboxymethylcellulose (CMC) in aqueous solution, with glutaraldehyde as a crosslinking agent and silica particles as porogens. The good compatibility between CS and CMC was confirmed by attenuated total reflectance Fourier-transform infrared spectroscopy (FTIR-ATR). A scanning electron microscope was used to observe the morphology of CS/CMC blend membranes, in which a three-dimensional opening structure was formed, and no phase separation was discovered. Tobacco extract was used as a separation model to get tobacco protein. And the effects of the pH value, adsorption time, CS/CMC content, initial protein concentration, and CS/CMC composition on tobacco protein adsorption were investigated by coomassie blue staining during the adsorption process. The results showed that the maximum adsorption capacity of 271.78 mg/g can be achieved under the condition of pH 6.15, adsorption time of 8 h, initial protein concentration of 1.52 mg/mL, and CS/CMC weight of 0.05 g with a mass ratio of 80 : 20. Tobacco proteins were successfully separated from tobacco extract by adjusting the pH of the feed and the desorption solutions to change their electrostatic force. It was found that the high desorption capacity and protein desorption efficiency can be achieved at pH 9.40. The blend membranes also demonstrated good reusability after 3 adsorption-desorption cycles.

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Chitosan adsorption on nanofibrillated cellulose with different aldehyde content and interaction with phosphate buffered saline

Ondaral

Çelik

Kurtuluş

et al. 2018

Carbohydrate Polymers

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Evaluation of Microcrystalline Chitosan and Fibrin Membranes as Platelet-Derived Growth Factor-BB Carriers with Amoxicillin

Cited by 4 publications

References 46 publications

In vitro evaluation of polymeric formulations designed for use in alveolar osteitis

In vitro evaluation of polymeric formulations designed for use in alveolar osteitis

The Amphoteric Ion Exchange Membrane Based on CS/CMC for Tobacco-Protein Adsorption and Separation from Tobacco Extract

Chitosan adsorption on nanofibrillated cellulose with different aldehyde content and interaction with phosphate buffered saline

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