Evaluation of Miconazole Nitrate Permeability Through Biological Membrane From Dermal Systems

Bîrsan, Magdalena

doi:10.31925/farmacia.2020.1.15

Cited by 7 publications

(10 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The Korsmeyer Peppas model includes the Korsmeyer Peppas constant, characterizing the dosage form and n is the release exponent. This exponent offers information about drug-release mechanism [6]. If n is below 0.5 the drug diffuses through and is released from polymeric film with a quasi-Fickian diffusion mechanism.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Dissolution Kinetic of Meloxicam From Hydrophilic Matrix-Type Films for Transdermal Therapy

Antonoaea¹

2021

FARMACIA

View full text Add to dashboard Cite

Taking into consideration the fact the transdermal administration of the active pharmaceutical ingredients can represent a therapeutic approach that increases the patient’s compliance, this study aims to evaluate the release of meloxicam (MX), a potent non-steroidal anti-inflammatory drug, incorporated in hydrophilic polymer-based matrices for transdermal therapeutic systems was studied. Three different formulations were realized by solvent casting method containing two types of hydroxypropyl methylcellulose (HPMCE5 with low viscosity and HPMC15000 with high viscosity) whose concentration was also varied. The drug release test was performed by Franz diffusion cell and the dissolution curves were analysed from a kinetical point of view by model dependent and model independent methods. Linearization by simple regression allowed the flux calculations of values that varied between 0.183 and 32.270 g/(cm2h). Based on the results obtained with the mathematical analysis, we can conclude that the MX release is influenced by the pH of the dissolution media and by the type and concentration of the matrix forming agent. Discrimination of model dependent mathematical models was done by the Akaike index with values between 49 and -62. The kinetic analysis of the MX releasing curves from the proposed formulations showed that Korsmeyer-Peppas was more suitable for the release characterisation of the active pharmaceutical ingredient from the transdermal therapeutic systems analysed.

show abstract

Section: Resultsmentioning

confidence: 99%

“…where K is the number of model parameters and τ the maximum value of the likehood function of the model. Flux rate and latency time calculation was realised by graphic method after the linearization of release profiles in the steady state [6,10,14,25] with Graph-Pad (version 7.05) and DDSolver software.…”

Section: Mathematical Modelling Of Release Profilesmentioning

confidence: 99%

Dissolution Kinetic of Meloxicam From Hydrophilic Matrix-Type Films for Transdermal Therapy

Antonoaea¹

2021

FARMACIA

View full text Add to dashboard Cite

show abstract

“…The samples were analyzed spectrophotometrically at 275 nm. The obtained release profiles were analyzed through a kinetic point of view (software: DDSolver Add-in Program, Microsoft Excel) [34][35][36][37][38].…”

Section: Fluoxetine In Vitro Releasementioning

confidence: 99%

Development and Evaluation of Fluoxetine Fast Dissolving Films: An Alternative for Noncompliance in Pediatric Patients

et al. 2021

Self Cite

View full text Add to dashboard Cite

The most used pharmaceutical formulations for children are syrups, suppositories, soft chewable capsules, and mini-tablets. Administrating them might create an administration discomfort. This study aimed to develop and evaluate orodispersible films (ODFs) for pediatric patients in which the fluoxetine (FX) is formulated in the polymeric matrix. Six FX fast dissolving films (10 mg FX/ODF), FX1, FX2, FX3, FX4, FX5, and FX6, were prepared by solvent casting technique. In the composition of the ODFs, the concentration of the hydroxypropyl methylcellulose and the concentration of the propylene glycol were varied. Each formulation of fluoxetine ODF was evaluated by determining the tensile strength, folding endurance, disintegration, behavior in the controlled humidity and temperature conditions, and adhesiveness. All the obtained results were compared with the results obtained for six ODFs prepared without FX. The disintegration time of the FX ODFs was of maximum 88 s for FX2. Via the in vitro releasing study of the FX from the ODFs it was noticed that FX1 and FX2 allow a better release of the drug 99.98 ± 3.81% and 97.67 ± 3.85% being released within 15 min. From the obtained results it was also confirmed that FX ODFs were found to follow first-order release kinetic.

show abstract

“…is an antifungal used in many diseases, being known as a beneficial adjuvant in acne therapy, as a single compound or in combinations [28,32]. Its significant advantage is that it remains cumulative in the stratum corneum for up to 4 days after application [11,56]. Thus, combining ADA with an antifungal, e.g.…”

Section: Miconazole Nitrate (Mic)mentioning

confidence: 99%

Compatibility Study of Four Binary Combinations of Active Ingredients for Dermal Film Forming Systems

Rusu¹

2020

FARMACIA

View full text Add to dashboard Cite

Adapalene (ADA), levofloxacin (LEV), meloxicam (MEL) and miconazole nitrate (MIC) were selected as potential active ingredients for film systems with dermal or transdermal delivery. This study aimed to evaluate the compatibility of four binary mixtures-ADA and LEV (M1), ADA and MIC (M2), LEV and MEL (M3), and LEV and MIC (M4)combinations for new bioadhesive polymeric matrix dermal systems produced by the casting solvent evaporation technique. The Fouriertransform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC) and molecular modelling (MM) were used to characterise and evaluate the compatibility between the selected active substances. In the FTIR data, M1, M2, and M4 mixtures presented a good compatibility. DSC revealed different chemical interactions as the temperature rose above 160°C, especially for M3 and M4. Through MM technique, interactions were found on the M2 and M3 mixtures. Following the correlation of all obtained results, the best compatibility was found to be on M1 and M4 combinations. Rezumat Adapalenul (ADA), levofloxacina (LEV), meloxicamul (MEL) şi nitratul de miconazol (MIC) au fost selectate ca potenţiale ingrediente active în sistemele de tip film cu eliberare dermică sau transdermică. Scopul acestui studiu este de a evalua compatibilitatea a patru amestecuri binare-ADA şi LEV (M1), ADA şi MIC (M2), LEV şi MEL (M3), şi LEV şi MIC (M4)-combinaţii pentru noi sisteme dermice de tip matriţă polimerică bioadezivă produse prin tehnica de turnare şi evaporare a solventului. Pentru a caracteriza şi evalua compatibilitatea dintre substanţele active selectate au fost utilizate spectroscopia cu transformată Fourier (FTIR), calorimetria cu scanare diferenţială (DSC) şi modelarea moleculară (MM). Din datele FTIR, amestecurile M1, M2 şi M4 au fost compatibilite. DSC a arătat diferite interacţiuni chimice, în special pentru M3 şi M4, la temperaturi mai mari de 160°C. Prin metoda MM au fost semnalate interacţiuni în combinaţiile M2 şi M3. Ca urmare a corelării tuturor rezultatelor obţinute, cea mai bună compatibilitate a fost găsită în combinaţiile M1 şi M4.

show abstract

Evaluation of Miconazole Nitrate Permeability Through Biological Membrane From Dermal Systems

Cited by 7 publications

References 13 publications

Dissolution Kinetic of Meloxicam From Hydrophilic Matrix-Type Films for Transdermal Therapy

Dissolution Kinetic of Meloxicam From Hydrophilic Matrix-Type Films for Transdermal Therapy

Development and Evaluation of Fluoxetine Fast Dissolving Films: An Alternative for Noncompliance in Pediatric Patients

Compatibility Study of Four Binary Combinations of Active Ingredients for Dermal Film Forming Systems

Contact Info

Product

Resources

About