Dissolution Kinetic of Meloxicam From Hydrophilic Matrix-Type Films for Transdermal Therapy

Abstract

Taking into consideration the fact the transdermal administration of the active pharmaceutical ingredients can represent a therapeutic approach that increases the patient’s compliance, this study aims to evaluate the release of meloxicam (MX), a potent non-steroidal anti-inflammatory drug, incorporated in hydrophilic polymer-based matrices for transdermal therapeutic systems was studied. Three different formulations were realized by solvent casting method containing two types of hydroxypropyl methylcellulose (HPMCE5 with low viscosity and HPMC15000 with high viscosity) whose concentration was also varied. The drug release test was performed by Franz diffusion cell and the dissolution curves were analysed from a kinetical point of view by model dependent and model independent methods. Linearization by simple regression allowed the flux calculations of values that varied between 0.183 and 32.270 g/(cm2h). Based on the results obtained with the mathematical analysis, we can conclude that the MX release is influenced by the pH of the dissolution media and by the type and concentration of the matrix forming agent. Discrimination of model dependent mathematical models was done by the Akaike index with values between 49 and -62. The kinetic analysis of the MX releasing curves from the proposed formulations showed that Korsmeyer-Peppas was more suitable for the release characterisation of the active pharmaceutical ingredient from the transdermal therapeutic systems analysed.

Influence of Dissolution Conditions on the Dissolution Rate and Release Mechanism of Ketoprofen From Extended Release Hydrophilic Matrix Systems

“…Understanding the effect of dissolution media on release kinetics and the mathematical description of dissolution process is of main importance for the process of selection of appropriate dissolution conditions and for efficient product development [1,19].…”

Design and Characterisation of New Dermal Polymeric Films for Treatment of Inflammatory Pain

“…Different types of diffusion cells are described each with different dimensions (the diffusion surface available has a diameter between 0.3 and 5.0 cm 2 ; a volume of the receptor solution between 2 and 20 mL), all having in common both an acceptor media and a donor media [1][2][3][4]. The Franz diffusimetric cell can be used in most of the studies that aim to establish the cutaneous permeability of some APIs [9][10][11]. The method that uses the vertical Franz cell enables the determination of the API released from a sample which in accordance with the 428 OECD/ OCDE specifications is deposited on a membrane (donor compartment).…”

“…The method that uses the vertical Franz cell enables the determination of the API released from a sample which in accordance with the 428 OECD/ OCDE specifications is deposited on a membrane (donor compartment). After the diffusion through the membrane's pores, the API is crossing the membrane in the acceptor compartment from where it can be quantified by applying a suitable dosage method for the selected API [9][10][11][12][13]. Among the most important parameters that are taken into consideration whilst using the Franz cell is the provision of a corresponding seal of the membrane and the analysed formulation, a good homogeneity of the receptor solution (found under the membrane), easy sampling at different time intervals and corresponding control of the temperature during the determinations.…”