Evaluation of metoclopramide and ranitidine on the prevention of gastroesophageal reflux episodes in anesthetized dogs

Favarato, Evandro Silva; Souza, Maria Verônica de; Costa, P.R.S.; Favarato, Lukiya Silva Campos; Nehme, Renata Castro; Monteiro, Betânia Souza; Bonfa, Laila P

doi:10.1016/j.rvsc.2011.07.027

Cited by 33 publications

(23 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The use of prokinetics, anti‐acids, or anti‐emetics and the incidence of post‐operative regurgitation were not explicitly studied here. There are mixed reports on benefits of using metoclopramide in dogs to reduce incident of regurgitation during or shortly after anaesthesia . Further studies focused on the use of these medications in brachycephalic dogs undergoing airway surgery would be beneficial.…”

Section: Discussionmentioning

confidence: 99%

Brachycephalic airway syndrome: management of post‐operative respiratory complications in 248 dogs

Lindsay

Cook

et al. 2020

Aust Veterinary J

View full text Add to dashboard Cite

Objective As ownership of brachycephalic dog breeds rises, the surgical correction of components of brachycephalic airway syndrome (BAS) is increasingly recommended by veterinarians. This study's objective was to describe the incidence of, and strategies for the management of post-operative respiratory complications in brachycephalic dogs undergoing surgical correction of one or more components of BAS.Methods Medical records of 248 brachycephalic dogs treated surgically for BAS were retrospectively reviewed for demographic information, procedures performed, post-operative complications and treatment implemented, hospitalisation time, and necessity for further surgery.Results Pugs, Cavalier King Charles Spaniels and British Bulldogs were the most commonly encountered breeds. Dogs which experienced a complication were significantly older (mean was 5.5 years, compared with 4.1 years [P < 0.01]). Fifty-eight dogs (23.4%) had complications which included: dyspnoea managed with supplemental oxygen alone (7.3%, n = 18), dyspnoea requiring anaesthesia and re-intubation (8.9%, n = 22), dyspnoea necessitating treatment with a temporary tracheostomy (8.9%, n = 22), aspiration pneumonia (4%, n = 10), and respiratory or cardiac arrest (2.4%, n = 6). Five of the 22 dogs requiring anaesthesia and re-intubation deteriorated 12 or more hours after post-surgical anaesthetic recovery. The overall mortality rate in this study was 2.4% (n = 6). Age, concurrent airway pathology, and emergency presentation significantly predicted post-operative complications.Conclusion Our data show the importance of close monitoring for a minimum of 24 h following surgery by an experienced veterinarian or veterinary technician. Surgical intervention for BAS symptomatic dogs should be considered at an earlier age as an elective procedure, to reduce the risk of post-operative complications.

show abstract

Section: Discussionmentioning

confidence: 99%

Brachycephalic airway syndrome: management of post‐operative respiratory complications in 248 dogs

Lindsay

Cook

et al. 2020

Aust Veterinary J

View full text Add to dashboard Cite

show abstract

“…However, cisapride with esomeprazole decreased reflux events. The study by Favarato et al (2012) evaluated metoclopramide or ranitidine on 90 anaesthetised dogs and concluded that there was no influence on the effect of GOR. However, Wilson et al (2006) concluded that whilst a low dose of metoclopramide had no effect on the incidence of GOR, administering a higher than normal dose of metoclopramide as a continuous infusion resulted in a 54% reduction in relative risk of developing GOR.…”

Section: The Evidencementioning

confidence: 99%

“…The patients in all the studies were fasted of food overnight or for at least 12 hours for consistency and is compatible with a normal clinical setting (Favarato et al, 2012;Johnson, 2014;Panti et al, 2009;Wilson et al, 2006;and Zacuto et al, 2012). The Johnson (2014) study concluded pre-anaesthetic maropitant can assist in reducing vomiting but not the incidence of GOR as the two groups showed a similar GOR event rate.…”

Section: Appraisal Application and Reflectionmentioning

confidence: 99%

In dogs undergoing anaesthesia do pre-anaesthetic gastroprotectants reduce gastro-oesophageal reflux?

Barry

2020

View full text Add to dashboard Cite

PICO question In dogs undergoing anaesthesia do pre-anaesthetic gastroprotectants reduce gastro-oesophageal reflux? Clinical bottom line Category of research question Treatment The number and type of study designs reviewed Five papers were critically reviewed. There was a randomised prospective study, two randomised blinded prospective studies, randomised non-blinded prospective study and a randomised, double blinded and placebo-controlled prospective study. Strength of evidence Moderate Outcomes reported Evidence of high quality suggests omeprazole or cisapride with esomeprazole decrease the incidence of gastro-oesophageal reflux (GOR) in the anaesthetised dog. In addition, a study of lower quality showed that continuous infusion of metoclopramide at a higher than normal dose rate decreased the incidence of GOR. Conclusion Omeprazole or cisapride with esomeprazole decreases the incidence of GOR in the anaesthetised dog. How to apply this evidence in practice The application of evidence into practice should take into account multiple factors, not limited to: individual clinical expertise, patient’s circumstances and owners’ values, country, location or clinic where you work, the individual case in front of you, the availability of therapies and resources. Knowledge Summaries are a resource to help reinforce or inform decision-making. They do not override the responsibility or judgement of the practitioner to do what is best for the animal in their care

show abstract

“…Conflicting reports make satisfactory conclusions that any particular drug will be a major risk factor difficult. Most anaesthetic agents will reduce tone in the LOS (Favarato and others 2012). A sound protocol with good anaesthetic safety remains a better basis for selection as reflux can be treated or prevented with additional drugs.…”

Section: Risk Factorsmentioning

confidence: 99%

Perioperative gastrointestinal reflux in dogs

Reid¹

2018

In Practice

View full text Add to dashboard Cite

Perioperative vomiting, regurgitation and reflux cause problems for veterinary patients during, but mostly after, anaesthesia. A history of gastrointestinal disease will often indicate the possibility of reflux, but many animals that regurgitate under anaesthesia have no previous history or predisposing factors, making this event an unwelcome surprise. If the refluxate fails to reach the larynx or mouth, the anaesthetist will be unaware and reflux will go untreated, with repeated incidents causing oesophagitis that can lead to stricture. Regurgitation complicates anaesthesia because animals have reduced or absent laryngeal reflexes and aspiration of refluxate leads to pneumonia. Following anaesthesia, irritation may make animals uncomfortable and less willing to eat, thus slowing their recovery and increasing any complications. This article aims to provide a greater depth of understanding as to why and how reflux occurs in anaesthetised dogs and what options are available for treatment.

show abstract

Evaluation of metoclopramide and ranitidine on the prevention of gastroesophageal reflux episodes in anesthetized dogs

Cited by 33 publications

References 8 publications

Brachycephalic airway syndrome: management of post‐operative respiratory complications in 248 dogs

Brachycephalic airway syndrome: management of post‐operative respiratory complications in 248 dogs

In dogs undergoing anaesthesia do pre-anaesthetic gastroprotectants reduce gastro-oesophageal reflux?

Perioperative gastrointestinal reflux in dogs

Contact Info

Product

Resources

About