Evaluation of melatonin levels in saliva in gingivitis and periodontitis cases: A pilot study

Lodhi, Karuna; Saimbi, Charanjeet Singh; Khan, MA; Nath, Chandishwar; Shukla, Rakesh

doi:10.4103/0976-237x.194115

Cited by 14 publications

(29 citation statements)

References 17 publications

(13 reference statements)

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“…Several research studies support the idea that melatonin could be used as a biomarker for monitoring the severity of periodontal disease [ 66 , 67 ], as well as a possible treatment strategy.…”

Section: Resultsmentioning

confidence: 99%

Melatonin: A Review of Its Potential Functions and Effects on Dental Diseases

Permuy

López-Peña

González‐Cantalapiedra

et al. 2017

IJMS

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Melatonin is a hormone synthesised and secreted by the pineal gland and other organs. Its secretion, controlled by an endogenous circadian cycle, has been proven to exert immunological, anti-oxidant, and anti-inflammatory effects that can be beneficial in the treatment of certain dental diseases. This article is aimed at carrying out a review of the literature published about the use of melatonin in the dental field and summarising its potential effects. In this review article, an extensive search in different databases of scientific journals was performed with the objective of summarising all of the information published on melatonin use in dental diseases, focussing on periodontal diseases and dental implantology. Melatonin released in a natural way into the saliva, or added as an external treatment, may have important implications for dental disorders, such as periodontal disease, as well as in the osseointegration of dental implants, due to its anti-inflammatory and osseoconductive effects. Melatonin has demonstrated to have beneficial effects on dental pathologies, although further research is needed to understand the exact mechanisms of this molecule.

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Section: Resultsmentioning

confidence: 99%

Melatonin: A Review of Its Potential Functions and Effects on Dental Diseases

Permuy

López-Peña

González‐Cantalapiedra

et al. 2017

IJMS

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show abstract

“…Moreover, the gingiva is one of the external sites of melatonin synthesis, and melatonin receptor 1 has been found in human gingiva, indicating that melatonin may play a receptor-mediating role in the oral cavity ( 122 ). Certain studies have suggested that melatonin may serve as a potential supplementary therapy and a biomarker detecting the dynamics of periodontal disease ( 123 , 124 ).…”

Section: Periodontitismentioning

confidence: 99%

Insight into the roles of melatonin in bone tissue and bone‑related diseases (Review)

Chen

et al. 2021

Int J Mol Med

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Bone-related diseases comprise a large group of common diseases, including fractures, osteoporosis and osteoarthritis (OA), which affect a large number of individuals, particularly the elderly. The progressive destruction and loss of alveolar bone caused by periodontitis is a specific type of bone loss, which has a high incidence and markedly reduces the quality of life of patients. With the existing methods of prevention and treatment, the incidence and mortality of bone-related diseases are still gradually increasing, creating a significant financial burden to societies worldwide. To prevent the occurrence of bone-related diseases, delay their progression or reverse the injuries they cause, new alternative or complementary treatments need to be developed. Melatonin exerts numerous physiological effects, including inducing anti-inflammatory and antioxidative functions, resetting circadian rhythms and promoting wound healing and tissue regeneration. Melatonin also participates in the health management of bone and cartilage. In the present review, the potential roles of melatonin in the pathogenesis and progression of bone injury, osteoporosis, OA and periodontitis are summarized. Furthermore, the high efficiency and diversity of the physiological regulatory effects of melatonin are highlighted and the potential benefits of the use of melatonin for the clinical prevention and treatment of bone-related diseases are discussed.

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“…In contrast, Lodhi et al stated that salivary melatonin levels increased with increased disease severity from control to periodontitis. They also observed that patients with periodontitis had the highest salivary melatonin levels, followed by gingivitis, while the lowest levels were reported in the healthy controls (22).…”

Section: Discussionmentioning

confidence: 93%

“…This case-control study was conducted to measure melatonin before and after non-surgical periodontal therapies and treatment efficiency. Sample size was calculated based on the study by Lodhi et al (22). In total, 60 participants (30 patients with moderate chronic periodontitis and 30 healthy controls) were recruited from the patients referring to the Periodontal Department of Babol University of Medical Sciences, Iran.…”

Section: Subjects and Study Designmentioning

confidence: 99%

Changes in Salivary Melatonin Levels by Scaling and Root Planing in Patients with Chronic Periodontitis

Purrahmani

Soghli

Qujeq

et al. 2021

J Kermanshah Univ Med Sci

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Background: Periodontitis is a chronic inflammatory disease that causes tissue destruction due to the imbalance in the oxidant-antioxidant system. Melatonin has anti-inflammatory, antioxidant, and immune-modulatory properties and is considered to be a biomarker and diagnostic/therapeutic agent in the pathogenesis of periodontitis. Objectives: The present study aimed to evaluate the salivary melatonin level and its changes following non-surgical periodontal therapy in patients with periodontitis. Methods: In total, 90 salivary samples were collected from 60 patients, including 30 from patients with moderate chronic periodontitis (before periodontal treatment), and 30 from the same patients one month after the non-surgical periodontal therapy, and 30 from periodontally healthy subjects (control). Salivary melatonin levels were measured using the competitive immunoassay of the human melatonin ELISA kit. Results: The highest melatonin concentration was observed in the control group (79.55 ± 59.22; P < 0.05), while the lowest concentration was observed in the pre-treatment group (P < 0.05). In addition, salivary melatonin concentration in the post-treatment group (56.58 ± 46.48) was significantly higher compared to the pre-treatment group (17.25 ± 5.79; P < 0.05). Conclusions: According to the results, salivary melatonin levels improved after non-surgical periodontal therapy, which suggests the involvement of melatonin in the pathogenesis of periodontitis. However, the exact role of melatonin requires further investigation.

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Evaluation of melatonin levels in saliva in gingivitis and periodontitis cases: A pilot study

Cited by 14 publications

References 17 publications

Melatonin: A Review of Its Potential Functions and Effects on Dental Diseases

Melatonin: A Review of Its Potential Functions and Effects on Dental Diseases

Insight into the roles of melatonin in bone tissue and bone‑related diseases (Review)

Changes in Salivary Melatonin Levels by Scaling and Root Planing in Patients with Chronic Periodontitis

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